Adcy9 adenylate cyclase 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adcy9provided by MGI
Official Full Name: adenylate cyclase 9provided by MGI
Primary source: MGI:MGI:108450
See related: Ensembl:ENSMUSG00000005580 AllianceGenome:MGI:108450
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AC9; ACtp10; D16Wsu65e; mKIAA0520
Summary: Enables adenylate cyclase activity. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway; cAMP biosynthetic process; and in utero embryonic development. Located in membrane. Is expressed in several structures, including genitourinary system; integumental system; nervous system; sensory organ; and skeleton. Orthologous to human ADCY9 (adenylate cyclase 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 16.6), ovary adult (RPKM 14.2) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A1; 16 2.42 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (4102750..4255094, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (4284886..4437236, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Adcy9 Gene Inactivation Improves Cardiac Function After Myocardial Infarction in Mice.
Title: Adcy9 Gene Inactivation Improves Cardiac Function After Myocardial Infarction in Mice.
Adcy9 inactivation protects against atherosclerosis, but only in the absence of CETP activity. This atheroprotection may be explained by decreased macrophage accumulation and proliferation in the arterial wall, and improved endothelial function and autonomic tone.
Title: ADCY9 (Adenylate Cyclase Type 9) Inactivation Protects From Atherosclerosis Only in the Absence of CETP (Cholesteryl Ester Transfer Protein).
Deletion of adenylyl cyclase type 9 results in a left ventricular diastolic dysfunction which correlates with reduced Hsp20-associated adenylyl cyclase type 9 activity and a significant 64% reduction in baseline Hsp20 phosphorylation.
Title: Loss of type 9 adenylyl cyclase triggers reduced phosphorylation of Hsp20 and diastolic dysfunction.
in heart, Yotiao brings together PKA, PP1, PDE4D3, AC9, and the I(Ks) channel to achieve localized temporal regulation of beta-adrenergic stimulation.
Title: The A-kinase anchoring protein Yotiao facilitates complex formation between adenylyl cyclase type 9 and the IKs potassium channel in heart.
miR-142-3p regulates the production of cAMP by targeting adenylyl cyclase (AC) 9 messenger RNA in CD4(+)CD25(-) T cells and CD4(+)CD25(+) T(REG) cells.
Title: miR-142-3p restricts cAMP production in CD4+CD25- T cells and CD4+CD25+ TREG cells by targeting AC9 mRNA.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125684 (e-PCR)
- UniSTS:142097

U30602 (e-PCR)
- UniSTS:125718

Adcy9 (e-PCR), detects polymorphism
- UniSTS:546633

AW125421 (e-PCR)
- UniSTS:165971

U30602 (e-PCR)
- UniSTS:163562

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
enables adenylate cyclase activity	ISO Inferred from Sequence Orthology more info
enables adenylate cyclase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cAMP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cAMP biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: adenylate cyclase type 9

Names: ATP pyrophosphate-lyase 9; adenylate cyclase type IX; adenylyl cyclase 9; adenylyl cyclase type 10

NP_001278839.1

EC 4.6.1.1

NP_001400201.1

EC 4.6.1.1

NP_001400202.1

EC 4.6.1.1

NP_033754.2

EC 4.6.1.1

XP_011244108.1

EC 4.6.1.1

XP_036015640.1

EC 4.6.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291910.2 → NP_001278839.1 adenylate cyclase type 9 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2), has a shorter N-terminus than isoform 1.

Source sequence(s)

AC087799, AC132575

Consensus CDS

CCDS79418.1

UniProtKB/TrEMBL

E9Q706

Related

ENSMUSP00000113421.2, ENSMUST00000120080.8

Conserved Domains (2) summary

smart00044
Location:89 → 307

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:148 → 336

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
NM_001413272.1 → NP_001400201.1 adenylate cyclase type 9 isoform 3

Status: VALIDATED

Source sequence(s)

AC087799, AC132575
NM_001413273.1 → NP_001400202.1 adenylate cyclase type 9 isoform 1

Status: VALIDATED

Source sequence(s)

AC087799, AC132575

UniProtKB/Swiss-Prot

P51830, Q61279
NM_009624.4 → NP_033754.2 adenylate cyclase type 9 isoform 1

See identical proteins and their annotated locations for NP_033754.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC087799, AC132575

Consensus CDS

CCDS27917.1

UniProtKB/Swiss-Prot

P51830, Q61279

Related

ENSMUSP00000113498.2, ENSMUST00000117801.8

Conserved Domains (3) summary

smart00044
Location:326 → 544

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:385 → 573

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam13515
Location:142 → 202

FUSC_2; Fusaric acid resistance protein-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

4102750..4255094 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011245806.2 → XP_011244108.1 adenylate cyclase type 9 isoform X1

See identical proteins and their annotated locations for XP_011244108.1

Conserved Domains (2) summary

pfam00211
Location:385 → 573

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

cl28910
Location:134 → 260

MFS; Major Facilitator Superfamily
XM_036159747.1 → XP_036015640.1 adenylate cyclase type 9 isoform X2

Conserved Domains (2) summary

pfam00211
Location:385 → 573

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

cl28910
Location:134 → 260

MFS; Major Facilitator Superfamily