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    C7 complement component 7 [ Mus musculus (house mouse) ]

    Gene ID: 109828, updated on 27-Nov-2024

    Summary

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    Official Symbol
    C7provided by MGI
    Official Full Name
    complement component 7provided by MGI
    Primary source
    MGI:MGI:88235
    See related
    Ensembl:ENSMUSG00000079105 AllianceGenome:MGI:88235
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1238; A530026G17
    Summary
    Predicted to be involved in complement activation and intracellular sodium ion homeostasis. Predicted to be part of membrane attack complex. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in complement component 7 deficiency. Orthologous to human C7 (complement C7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in bladder adult (RPKM 23.3), genital fat pad adult (RPKM 21.0) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 A1; 15 1.98 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (5017232..5093230, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (4987750..5063773, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene maestro heat-like repeat family member 2B Neighboring gene STARR-seq mESC enhancer starr_37838 Neighboring gene STARR-seq mESC enhancer starr_37841 Neighboring gene predicted gene, 25652 Neighboring gene STARR-positive B cell enhancer ABC_E8583 Neighboring gene caspase recruitment domain family, member 6 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1171 Neighboring gene caspase recruitment domain family, member 6 Neighboring gene ribosomal protein L37

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Monoclonal Antibodies Capable of Inhibiting Complement Downstream of C5 in Multiple Species. Zelek WM, et al. Front Immunol, 2020. PMID 33424866, Free PMC Article
    2. Complement factor C7 contributes to lung immunopathology caused by Mycobacterium tuberculosis. Welsh KJ, et al. Clin Dev Immunol, 2012. PMID 22973398, Free PMC Article
    3. Targeting terminal pathway reduces brain complement activation, amyloid load and synapse loss, and improves cognition in a mouse model of dementia. Zelek WM, et al. Brain Behav Immun, 2024 May. PMID 38485063
    4. Brain-penetrant complement inhibition mitigates neurodegeneration in an Alzheimer's disease mouse model. Zelek WM, et al. Brain, 2024 Aug 31. PMID 39215579
    5. Linkage between complement components 6 and 7 and glutamic pyruvate transaminase in the marsupial Monodelphis domestica. van Oorschot RA, et al. Biochem Genet, 1993 Jun. PMID 8259924

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1)  1 citation

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in complement activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular sodium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of membrane attack complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of membrane attack complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    complement component C7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243837.2 → NP_001230766.1  complement component C7 precursor

      Status: VALIDATED

      Source sequence(s)
      AC115877, AC131919
      Consensus CDS
      CCDS56974.1
      UniProtKB/TrEMBL
      D3YXF5
      Related
      ENSMUSP00000106317.4, ENSMUST00000110689.5
      Conserved Domains (6) summary
      cd00033
      Location:631 → 689
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00057
      Location:772 → 841
      FIMAC; factor I membrane attack complex
      smart00209
      Location:503 → 549
      TSP1; Thrombospondin type 1 repeats
      smart00457
      Location:249 → 448
      MACPF; membrane-attack complex / perforin
      cd00112
      Location:87 → 119
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00084
      Location:571 → 626
      Sushi; Sushi repeat (SCR repeat)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      5017232..5093230 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248274.1 → XP_030104134.1  complement component C7 isoform X1

      Conserved Domains (5) summary
      PHA02831
      Location:325 → 447
      PHA02831; EEV host range protein; Provisional
      smart00209
      Location:260 → 306
      TSP1; Thrombospondin type 1 repeats
      smart00457
      Location:6 → 205
      MACPF; membrane-attack complex / perforin
      pfam18434
      Location:549 → 596
      Kazal_3; Kazal-type serine protease inhibitor domain
      cl20168
      Location:460 → 523
      Kazal_3; Kazal-type serine protease inhibitor domain

    2. XM_030248275.2 → XP_030104135.1  complement component C7 isoform X1

      Conserved Domains (5) summary
      PHA02831
      Location:325 → 447
      PHA02831; EEV host range protein; Provisional
      smart00209
      Location:260 → 306
      TSP1; Thrombospondin type 1 repeats
      smart00457
      Location:6 → 205
      MACPF; membrane-attack complex / perforin
      pfam18434
      Location:549 → 596
      Kazal_3; Kazal-type serine protease inhibitor domain
      cl20168
      Location:460 → 523
      Kazal_3; Kazal-type serine protease inhibitor domain
    Nucleotide Protein Strain
    Heading Accession and Version

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