Dis3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dis3provided by MGI
Official Full Name: DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonucleaseprovided by MGI
Primary source: MGI:MGI:1919912
See related: Ensembl:ENSMUSG00000033166 AllianceGenome:MGI:1919912
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2810028N01Rik
Summary: Predicted to enable 3'-5'-RNA exonuclease activity; endonuclease activity; and guanyl-nucleotide exchange factor activity. Predicted to be involved in RNA metabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Is expressed in renal cortex; telencephalon ventricular layer; and thymus primordium. Orthologous to human DIS3 (DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 7.1), limb E14.5 (RPKM 5.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 E2.2; 14 49.25 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (99314070..99337217, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (99076634..99099780, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DIS3 ribonuclease is essential for spermatogenesis and male fertility in mice.
Title: DIS3 ribonuclease is essential for spermatogenesis and male fertility in mice.
RNA exosome ribonuclease DIS3 degrades Pou6f1 to promote mouse pre-implantation cell differentiation.
Title: RNA exosome ribonuclease DIS3 degrades Pou6f1 to promote mouse pre-implantation cell differentiation.
Epididymal DIS3 exosome ribonuclease is not necessary for mouse sperm maturation or fertility.
Title: Epididymal DIS3 exosome ribonuclease is not necessary for mouse sperm maturation or fertility.
MicroRNA-125a/b-5p promotes malignant behavior in multiple myeloma cells and xenograft tumor growth by targeting DIS3.
Title: MicroRNA-125a/b-5p promotes malignant behavior in multiple myeloma cells and xenograft tumor growth by targeting DIS3.
Noncoding RNA processing by DIS3 regulates chromosomal architecture and somatic hypermutation in B cells.
Title: Noncoding RNA processing by DIS3 regulates chromosomal architecture and somatic hypermutation in B cells.
The study establishes that the ribonuclease DIS3, targeting LIN28B, sustains the maturation of let-7 miRNAs and suggests the increased translation of critical oncogenes as one of the biological outcomes of DIS3 inactivation.
Title: The ribonuclease DIS3 promotes let-7 miRNA maturation by degrading the pluripotency factor LIN28B mRNA.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3'-5'-RNA exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3'-5'-RNA exonuclease activity	ISO Inferred from Sequence Orthology more info
enables 3'-5'-RNA exonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables endonuclease activity	ISO Inferred from Sequence Orthology more info
enables endonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in CUT catabolic process	IEA Inferred from Electronic Annotation more info
involved_in CUT catabolic process	ISO Inferred from Sequence Orthology more info
involved_in RNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in RNA processing	ISO Inferred from Sequence Orthology more info
involved_in nuclear mRNA surveillance of mRNA 3'-end processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA catabolic process	IEA Inferred from Electronic Annotation more info
involved_in rRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of cytoplasmic exosome (RNase complex)	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of exosome (RNase complex)	NAS Non-traceable Author Statement more info	PubMed
part_of nuclear exosome (RNase complex)	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear exosome (RNase complex)	ISO Inferred from Sequence Orthology more info
part_of nuclear exosome (RNase complex)	ISS Inferred from Sequence or Structural Similarity more info
part_of nuclear exosome (RNase complex)	NAS Non-traceable Author Statement more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: exosome complex exonuclease RRP44

Names: DIS3 mitotic control homolog; protein DIS3 homolog; ribosomal RNA-processing protein 44

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360050.1 → NP_001346979.1 exosome complex exonuclease RRP44 isoform 2

Status: VALIDATED

Source sequence(s)

AC154843, AK032091, AK038313, CN705423

Conserved Domains (2) summary

COG0557
Location:101 → 836

VacB; Exoribonuclease R [Transcription]

cl14812
Location:1 → 103

PIN_SF; PIN (PilT N terminus) domain: Superfamily
NM_001360051.1 → NP_001346980.1 exosome complex exonuclease RRP44 isoform 3

Status: VALIDATED

Source sequence(s)

AC154843, AK032091, AK038313, CN705423

Conserved Domains (1) summary

COG0557
Location:2 → 741

VacB; Exoribonuclease R [Transcription]
NM_028315.2 → NP_082591.2 exosome complex exonuclease RRP44 isoform 1

See identical proteins and their annotated locations for NP_082591.2

Status: VALIDATED

Source sequence(s)

AC154843, AK012840, AK032091, CJ176790, CN705423

Consensus CDS

CCDS49555.1

UniProtKB/Swiss-Prot

Q6ZQ07, Q8C074, Q9CSH3

Related

ENSMUSP00000041906.10, ENSMUST00000042471.11

Conserved Domains (3) summary

cd09862
Location:9 → 197

PIN_Rrp44; PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs

COG0557
Location:195 → 930

VacB; Exoribonuclease R [Transcription]

pfam00773
Location:467 → 795

RNB; RNB domain

RNA

NR_153390.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC154843, AK012840, AK032091, AK038313, CN705423

Related

ENSMUST00000228643.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

99314070..99337217 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006519602.5 → XP_006519665.1 exosome complex exonuclease RRP44 isoform X3

Conserved Domains (2) summary

COG0557
Location:165 → 900

VacB; Exoribonuclease R [Transcription]

cd09862
Location:9 → 167

PIN_Rrp44-like; VapC-like PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs
XM_030248047.1 → XP_030103907.1 exosome complex exonuclease RRP44 isoform X1

Conserved Domains (1) summary

COG0557
Location:2 → 741

VacB; Exoribonuclease R [Transcription]
XM_017316212.3 → XP_017171701.1 exosome complex exonuclease RRP44 isoform X2

UniProtKB/TrEMBL

A0A2I3BR78

Conserved Domains (2) summary

cd09862
Location:9 → 197

PIN_Rrp44-like; VapC-like PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs

cl39058
Location:195 → 545

RNB; RNB domain