Mzt1 mitotic spindle organizing protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mzt1provided by MGI
Official Full Name: mitotic spindle organizing protein 1provided by MGI
Primary source: MGI:MGI:1924039
See related: Ensembl:ENSMUSG00000033186 AllianceGenome:MGI:1924039
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mozart1; 2410129H14Rik
Summary: Predicted to be involved in gamma-tubulin complex localization; microtubule nucleation by interphase microtubule organizing center; and mitotic spindle assembly. Predicted to be located in cytoplasm. Predicted to be part of gamma-tubulin ring complex. Predicted to be active in centrosome; interphase microtubule organizing center; and spindle. Is expressed in several structures, including central nervous system; primary oocyte; and retina. Orthologous to human MZT1 (mitotic spindle organizing protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in whole brain E14.5 (RPKM 17.8), CNS E18 (RPKM 17.4) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 E2.2; 14 49.22 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (99271980..99283898, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (99034544..99046453, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127426 (e-PCR)
- UniSTS:210736

NoName (e-PCR)
- UniSTS:493876

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

RH135903 (e-PCR)
- UniSTS:209901

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in gamma-tubulin complex localization	ISO Inferred from Sequence Orthology more info
involved_in gamma-tubulin complex localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule nucleation by interphase microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of gamma-tubulin ring complex	IBA Inferred from Biological aspect of Ancestor more info
part_of gamma-tubulin ring complex	ISO Inferred from Sequence Orthology more info
part_of gamma-tubulin ring complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in interphase microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
is_active_in spindle	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle	ISO Inferred from Sequence Orthology more info
located_in spindle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: mitotic-spindle organizing protein 1

Names: mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.