Naip2 NLR family, apoptosis inhibitory protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Naip2provided by MGI
Official Full Name: NLR family, apoptosis inhibitory protein 2provided by MGI
Primary source: MGI:MGI:1298226
See related: Ensembl:ENSMUSG00000078945 AllianceGenome:MGI:1298226
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Birc1b; Naip-rs6
Summary: Predicted to enable ATP binding activity; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; and protein serine/threonine kinase binding activity. Involved in defense response to bacterium; detection of bacterium; and pyroptotic inflammatory response. Acts upstream of or within cellular response to estrogen stimulus. Part of IPAF inflammasome complex. Is expressed in several structures, including central nervous system; heart; liver; male reproductive system; and urinary system. Orthologous to human NAIP (NLR family apoptosis inhibitory protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in large intestine adult (RPKM 11.9), colon adult (RPKM 8.3) and 12 other tissues See more
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Genomic context

Location:: 13 D1; 13 53.01 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (100280571..100338630, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (100144063..100202122, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Naip1 is uniquely required to detect T3SS needle protein and Naip2 is uniquely required to detect T3SS inner rod protein, but neither Naip1 nor Naip2 is required for detection of flagellin.
Title: NAIP proteins are required for cytosolic detection of specific bacterial ligands in vivo.
These results provide definitive genetic evidence for the important physiological function of NAIPs in antibacterial defense and inflammatory damage-induced lethality in mice.
Title: Genetic functions of the NAIP family of inflammasome receptors for bacterial ligands in mice.
activation of caspase-1 by Shigella is triggered by the rod protein MxiI that interacts with Naip2 to induce activation of the Nlrc4 inflammasome independently of the Pkcdelta kinase
Title: Shigella type III secretion protein MxiI is recognized by Naip2 to induce Nlrc4 inflammasome activation independently of Pkcδ.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D13Die23 (e-PCR), detects polymorphism
- UniSTS:141909

D13Die24 (e-PCR), detects polymorphism
- UniSTS:141910

D13Die26 (e-PCR), detects polymorphism
- UniSTS:141912

Birc1b (e-PCR), detects polymorphism
- UniSTS:256359

AF102871 (e-PCR)
- UniSTS:180588

D13Die31a (e-PCR), detects polymorphism
- UniSTS:186736

Birc1a (e-PCR), detects polymorphism
- UniSTS:143985

Birc1-rs1 (e-PCR), detects polymorphism
- UniSTS:143986

Birc1-rs1 (e-PCR), detects polymorphism
- UniSTS:143987

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to estrogen stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in pyroptotic inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyroptotic inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_negative_effect regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in response to amino acid	IEA Inferred from Electronic Annotation more info
involved_in response to axon injury	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of IPAF inflammasome complex	IBA Inferred from Biological aspect of Ancestor more info
part_of IPAF inflammasome complex	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: baculoviral IAP repeat-containing protein 1b

Names: neuronal apoptosis inhibitory protein, related sequence 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001126182.2 → NP_001119654.1 baculoviral IAP repeat-containing protein 1b

See identical proteins and their annotated locations for NP_001119654.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AY147001, BY154503, CT030167

Consensus CDS

CCDS26726.1

UniProtKB/Swiss-Prot

A9C470, O09124, Q9QUK4, Q9R030

UniProtKB/TrEMBL

Q540N6, Q8CGT0

Related

ENSMUSP00000070827.6, ENSMUST00000067975.12

Conserved Domains (6) summary

smart00238
Location:159 → 229

BIR; Baculoviral inhibition of apoptosis protein repeat

smart00382
Location:507 → 644

AAA; ATPases associated with a variety of cellular activities

cd00022
Location:61 → 129

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00116
Location:1106 → 1373

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00034
Location:1201 → 1226

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:508 → 662

NACHT; NACHT domain
NM_010872.3 → NP_035002.2 baculoviral IAP repeat-containing protein 1b

See identical proteins and their annotated locations for NP_035002.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AY147001, BY154503, CT030167

Consensus CDS

CCDS26726.1

UniProtKB/Swiss-Prot

A9C470, O09124, Q9QUK4, Q9R030

UniProtKB/TrEMBL

Q540N6, Q8CGT0

Related

ENSMUSP00000113890.2, ENSMUST00000117913.8

Conserved Domains (6) summary

smart00238
Location:159 → 229

BIR; Baculoviral inhibition of apoptosis protein repeat

smart00382
Location:507 → 644

AAA; ATPases associated with a variety of cellular activities

cd00022
Location:61 → 129

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00116
Location:1106 → 1373

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00034
Location:1201 → 1226

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:508 → 662

NACHT; NACHT domain