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    Slc66a3 solute carrier family 66 member 3 [ Mus musculus (house mouse) ]

    Gene ID: 217430, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Slc66a3provided by MGI
    Official Full Name
    solute carrier family 66 member 3provided by MGI
    Primary source
    MGI:MGI:2444067
    See related
    Ensembl:ENSMUSG00000045679 AllianceGenome:MGI:2444067
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pqlc3; E030024M05Rik
    Summary
    Predicted to be located in membrane. Is expressed in brain; lower jaw molar; olfactory epithelium; and upper jaw molar. Orthologous to human SLC66A3 (solute carrier family 66 member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 7.3), bladder adult (RPKM 5.8) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc66a3 in Genome Data Viewer
    Location:
    12 A1.1; 12 8.04 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (17038649..17050385, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (16988648..17000386, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31647 Neighboring gene predicted gene, 36495 Neighboring gene STARR-seq mESC enhancer starr_31650 Neighboring gene Rho-associated coiled-coil containing protein kinase 2 Neighboring gene predicted gene, 22303 Neighboring gene STARR-seq mESC enhancer starr_31651 Neighboring gene STARR-positive B cell enhancer ABC_E7121 Neighboring gene STARR-positive B cell enhancer ABC_E11504 Neighboring gene ciliary microtubule inner protein 5 Neighboring gene STARR-seq mESC enhancer starr_31652 Neighboring gene STARR-seq mESC enhancer starr_31653 Neighboring gene potassium voltage-gated channel, subfamily F, member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of novel radiation-induced p53-dependent transcripts extensively regulated during mouse brain development. Quintens R, et al. Biol Open, 2015 Feb 13. PMID 25681390, Free PMC Article
    2. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 66 member 3
    Names
    PQ loop repeat containing 3
    PQ-loop repeat-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172574.2 → NP_766162.2  solute carrier family 66 member 3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_766162.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC155305, AK053171, AK138680, AK150094, BY236955
      Consensus CDS
      CCDS25824.1
      UniProtKB/Swiss-Prot
      Q8C6U2, Q8QZS7
      Related
      ENSMUSP00000054462.5, ENSMUST00000054536.11
      Conserved Domains (1) summary
      pfam04193
      Location:5 → 53
      PQ-loop; PQ loop repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      17038649..17050385 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515056.5 → XP_006515119.1  solute carrier family 66 member 3 isoform X1

      UniProtKB/TrEMBL
      A0A1Y7VLY9, Q3UU83
      Related
      ENSMUSP00000152715.2, ENSMUST00000222203.2
      Conserved Domains (1) summary
      pfam04193
      Location:5 → 53
      PQ-loop; PQ loop repeat

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001161111.1: Suppressed sequence

      Description
      NM_001161111.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C6U2.1 GenPept UniProtKB/Swiss-Prot:Q8C6U2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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