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    5730507C01Rik RIKEN cDNA 5730507C01 gene [ Mus musculus (house mouse) ]

    Gene ID: 236366, updated on 27-Nov-2024

    Summary

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    Official Symbol
    5730507C01Rikprovided by MGI
    Official Full Name
    RIKEN cDNA 5730507C01 geneprovided by MGI
    Primary source
    MGI:MGI:1917882
    See related
    Ensembl:ENSMUSG00000073197 AllianceGenome:MGI:1917882
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See 5730507C01Rik in Genome Data Viewer
    Location:
    12 A1.2; 12 8.17 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (18564441..18588211)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (18514440..18538114)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene 7093 Neighboring gene predicted gene 9231 Neighboring gene zinc finger protein 996 Neighboring gene predicted gene, 19786 Neighboring gene predicted pseudogene 9237 Neighboring gene predicted gene, 49760

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033157.4 → NP_001028329.1  zinc finger protein-like isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AK017753, AK139861, BY717547, DV648789
      Consensus CDS
      CCDS49035.1
      UniProtKB/TrEMBL
      Q3UT17
      Related
      ENSMUSP00000099112.2, ENSMUST00000063216.6
      Conserved Domains (5) summary
      smart00349
      Location:45 → 86
      KRAB; krueppel associated box
      COG5048
      Location:198 → 350
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:230 → 250
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:45 → 82
      KRAB; KRAB box
      pfam13465
      Location:298 → 322
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001201330.1 → NP_001188259.1  zinc finger protein-like isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK017753, AK139861, CT030157, DV648789
      Consensus CDS
      CCDS56831.1
      UniProtKB/TrEMBL
      J3QPX0
      Related
      ENSMUSP00000137525.2, ENSMUST00000177778.9
      Conserved Domains (5) summary
      smart00349
      Location:69 → 110
      KRAB; krueppel associated box
      COG5048
      Location:222 → 374
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:254 → 274
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:69 → 106
      KRAB; KRAB box
      pfam13465
      Location:322 → 346
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      18564441..18588211
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243861.3 → XP_011242163.1  zinc finger protein-like isoform X1

      Conserved Domains (1) summary
      pfam01352
      Location:45 → 85
      KRAB; KRAB box
    Nucleotide Protein Strain
    Heading Accession and Version

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