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    Fn3krp fructosamine 3 kinase related protein [ Mus musculus (house mouse) ]

    Gene ID: 238024, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Fn3krpprovided by MGI
    Official Full Name
    fructosamine 3 kinase related proteinprovided by MGI
    Primary source
    MGI:MGI:2679256
    See related
    Ensembl:ENSMUSG00000039253 AllianceGenome:MGI:2679256
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FN3K-RP
    Summary
    Predicted to enable kinase activity and protein-ribulosamine 3-kinase activity. Predicted to be involved in peptidyl-lysine deglycation. Predicted to be active in cytosol. Is expressed in liver. Orthologous to human FN3KRP (fructosamine 3 kinase related protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 15.4), liver E14.5 (RPKM 15.2) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fn3krp in Genome Data Viewer
    Location:
    11 E2; 11 85.37 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (121312199..121322114)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (121421373..121431288)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene WD repeat domain 45B Neighboring gene STARR-seq mESC enhancer starr_31380 Neighboring gene Rab40B, member RAS oncogene family Neighboring gene microRNA 7236 Neighboring gene STARR-positive B cell enhancer mm9_chr11:121282511-121282812 Neighboring gene STARR-positive B cell enhancer mm9_chr11:121312999-121313300 Neighboring gene fructosamine 3 kinase Neighboring gene tubulin-specific chaperone d Neighboring gene STARR-seq mESC enhancer starr_31381 Neighboring gene zinc finger protein 750

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A mammalian protein homologous to fructosamine-3-kinase is a ketosamine-3-kinase acting on psicosamines and ribulosamines but not on fructosamines. Collard F, et al. Diabetes, 2003 Dec. PMID 14633848
    2. Fructosamine 3-kinase-related protein and deglycation in human erythrocytes. Collard F, et al. Biochem J, 2004 Aug 15. PMID 15137908, Free PMC Article
    3. Tissue distribution and evolution of fructosamine 3-kinase and fructosamine 3-kinase-related protein. Delplanque J, et al. J Biol Chem, 2004 Nov 5. PMID 15331600
    4. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. fructosamine 3-kinase and fructosamine 3-kinase-related protein have roles in repairing damage caused by ribose 5-phosphate
      Title: Tissue distribution and evolution of fructosamine 3-kinase and fructosamine 3-kinase-related protein.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC40640

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-ribulosamine 3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptidyl-lysine deglycation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ketosamine-3-kinase
    Names
    FN3K-related protein
    ortholog of human fructosamine-3-kinase-related protein FN3KRP
    protein-psicosamine 3-kinase FN3KRP
    NP_852085.2
    XP_006533337.1
    XP_036012573.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181420.3 → NP_852085.2  ketosamine-3-kinase

      See identical proteins and their annotated locations for NP_852085.2

      Status: VALIDATED

      Source sequence(s)
      AL663088
      Consensus CDS
      CCDS25775.1
      UniProtKB/Swiss-Prot
      B1ATT5, Q8K274
      Related
      ENSMUSP00000038061.8, ENSMUST00000038096.8
      Conserved Domains (1) summary
      cl21453
      Location:21 → 307
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      121312199..121322114
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533274.1 → XP_006533337.1  ketosamine-3-kinase isoform X1

      Conserved Domains (1) summary
      cl21453
      Location:21 → 324
      PKc_like; Protein Kinases, catalytic domain

    2. XM_036156680.1 → XP_036012573.1  ketosamine-3-kinase isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:48 → 198
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K274.2 GenPept UniProtKB/Swiss-Prot:Q8K274

    Gene LinkOut

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