U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Slc16a3 solute carrier family 16 (monocarboxylic acid transporters), member 3 [ Mus musculus (house mouse) ]

    Gene ID: 80879, updated on 27-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Slc16a3provided by MGI
    Official Full Name
    solute carrier family 16 (monocarboxylic acid transporters), member 3provided by MGI
    Primary source
    MGI:MGI:1933438
    See related
    Ensembl:ENSMUSG00000025161 AllianceGenome:MGI:1933438
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mct3; Mct4
    Summary
    Enables lactate transmembrane transporter activity. Involved in pyruvate catabolic process. Is active in plasma membrane. Is expressed in several structures, including alimentary system; brain; early conceptus; gonad; and skeleton. Orthologous to human SLC16A3 (solute carrier family 16 member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in placenta adult (RPKM 14.2), duodenum adult (RPKM 13.7) and 22 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Slc16a3 in Genome Data Viewer
    Location:
    11 E2; 11 84.73 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120839310..120849826)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120948484..120959000)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 57 Neighboring gene STARR-seq mESC enhancer starr_31373 Neighboring gene RIKEN cDNA A430102A20 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:120794121-120794304 Neighboring gene STARR-seq mESC enhancer starr_31376 Neighboring gene casein kinase 1, delta Neighboring gene STARR-positive B cell enhancer ABC_E8477 Neighboring gene predicted gene, 53204 Neighboring gene predicted gene, 30062

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Monocarboxylate transporter 4 deficiency enhances high-intensity interval training-induced metabolic adaptations in skeletal muscle. Tamura Y, et al. J Physiol, 2024 Apr. PMID 38513062
    2. MCT4-dependent lactate transport: a novel mechanism for cardiac energy metabolism injury and inflammation in type 2 diabetes mellitus. Ma XM, et al. Cardiovasc Diabetol, 2024 Mar 14. PMID 38486199, Free PMC Article
    3. Monocarboxylate Transporter 4 (MCT4) Knockout Mice Have Attenuated 4NQO Induced Carcinogenesis; A Role for MCT4 in Driving Oral Squamous Cell Cancer. Bisetto S, et al. Front Oncol, 2018. PMID 30211114, Free PMC Article
    4. Prolonged hypoxia induces monocarboxylate transporter-4 expression in mesenchymal stem cells resulting in a secretome that is deleterious to cardiovascular repair. Saraswati S, et al. Stem Cells, 2015 Apr. PMID 25537659, Free PMC Article
    5. MCT4 defines a glycolytic subtype of pancreatic cancer with poor prognosis and unique metabolic dependencies. Baek G, et al. Cell Rep, 2014 Dec 24. PMID 25497091

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Monocarboxylate transporter 4 deficiency enhances high-intensity interval training-induced metabolic adaptations in skeletal muscle.
      Title: Monocarboxylate transporter 4 deficiency enhances high-intensity interval training-induced metabolic adaptations in skeletal muscle.
    2. MCT4-dependent lactate transport: a novel mechanism for cardiac energy metabolism injury and inflammation in type 2 diabetes mellitus.
      Title: MCT4-dependent lactate transport: a novel mechanism for cardiac energy metabolism injury and inflammation in type 2 diabetes mellitus.
    3. Identification of Intron Retention in the Slc16a3 Gene Transcript Encoding the Transporter MCT4 in the Brain of Aged and Alzheimer-Disease Model (APPswePS1dE9) Mice.
      Title: Identification of Intron Retention in the Slc16a3 Gene Transcript Encoding the Transporter MCT4 in the Brain of Aged and Alzheimer-Disease Model (APPswePS1dE9) Mice.
    4. Loss of microglial MCT4 leads to defective synaptic pruning and anxiety-like behavior in mice.
      Title: Loss of microglial MCT4 leads to defective synaptic pruning and anxiety-like behavior in mice.
    5. MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma.
      Title: MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma.
    6. Lactate secreted via MCT4 from bonecolonizing breast cancer excites sensory neurons via GPR81.
      Title: Lactate secreted via MCT4 from bone‑colonizing breast cancer excites sensory neurons via GPR81.
    7. Monocarboxylate transporter 4 inhibition potentiates hepatocellular carcinoma immunotherapy through enhancing T cell infiltration and immune attack.
      Title: Monocarboxylate transporter 4 inhibition potentiates hepatocellular carcinoma immunotherapy through enhancing T cell infiltration and immune attack.
    8. Knockdown of Astrocytic Monocarboxylate Transporter 4 in the Motor Cortex Leads to Loss of Dendritic Spines and a Deficit in Motor Learning.
      Title: Knockdown of Astrocytic Monocarboxylate Transporter 4 in the Motor Cortex Leads to Loss of Dendritic Spines and a Deficit in Motor Learning.
    9. The MCT4-inhibition-induced disruption of tumor intracellular pH holds promise as a therapy against not only HCC.
      Title: Targeted inhibition of MCT4 disrupts intracellular pH homeostasis and confers self-regulated apoptosis on hepatocellular carcinoma.
    10. MCT1 inhibition impairs proliferation of glycolytic breast cancer cells co-expressing MCT1 and MCT4 via disruption of pyruvate rather than lactate export.
      Title: MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lactate transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables lactate:proton symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lactate:proton symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lactate:proton symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables pyruvate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pyruvate transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in lactate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lactate transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in plasma membrane lactate transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pyruvate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pyruvate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pyruvate transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basolateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in parallel fiber to Purkinje cell synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    monocarboxylate transporter 4
    Names
    MCT 4
    solute carrier family 16 member 3

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038653.1 → NP_001033742.1  monocarboxylate transporter 4

      See identical proteins and their annotated locations for NP_001033742.1

      Status: VALIDATED

      Source sequence(s)
      AK149707, AK166048
      Consensus CDS
      CCDS25761.1
      UniProtKB/Swiss-Prot
      P57787, Q9ES80, Q9ESF8
      UniProtKB/TrEMBL
      Q3TMA0, Q3UDP9
      Related
      ENSMUSP00000125846.2, ENSMUST00000168579.8
      Conserved Domains (1) summary
      cd17430
      Location:21 → 410
      MFS_MCT3_4; Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters

    2. NM_001038654.1 → NP_001033743.1  monocarboxylate transporter 4

      See identical proteins and their annotated locations for NP_001033743.1

      Status: VALIDATED

      Source sequence(s)
      AK149707, AK165596, AK166048
      Consensus CDS
      CCDS25761.1
      UniProtKB/Swiss-Prot
      P57787, Q9ES80, Q9ESF8
      UniProtKB/TrEMBL
      Q3TMA0, Q3UDP9
      Related
      ENSMUSP00000097706.4, ENSMUST00000100130.10
      Conserved Domains (1) summary
      cd17430
      Location:21 → 410
      MFS_MCT3_4; Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters

    3. NM_030696.3 → NP_109621.1  monocarboxylate transporter 4

      See identical proteins and their annotated locations for NP_109621.1

      Status: VALIDATED

      Source sequence(s)
      AK166048, BC046525
      Consensus CDS
      CCDS25761.1
      UniProtKB/Swiss-Prot
      P57787, Q9ES80, Q9ESF8
      UniProtKB/TrEMBL
      Q3TMA0, Q3UDP9
      Related
      ENSMUSP00000068854.7, ENSMUST00000070653.13
      Conserved Domains (1) summary
      cd17430
      Location:21 → 410
      MFS_MCT3_4; Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      120839310..120849826
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157107.1 → XP_036013000.1  monocarboxylate transporter 4 isoform X1

      UniProtKB/Swiss-Prot
      P57787, Q9ES80, Q9ESF8
      UniProtKB/TrEMBL
      Q3TMA0, Q3UDP9
      Conserved Domains (1) summary
      cd17430
      Location:21 → 410
      MFS_MCT3_4; Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters

    2. XM_011249321.3 → XP_011247623.1  monocarboxylate transporter 4 isoform X1

      See identical proteins and their annotated locations for XP_011247623.1

      UniProtKB/Swiss-Prot
      P57787, Q9ES80, Q9ESF8
      UniProtKB/TrEMBL
      Q3TMA0, Q3UDP9
      Conserved Domains (1) summary
      cd17430
      Location:21 → 410
      MFS_MCT3_4; Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters

    3. XM_011249322.4 → XP_011247624.1  monocarboxylate transporter 4 isoform X1

      See identical proteins and their annotated locations for XP_011247624.1

      UniProtKB/Swiss-Prot
      P57787, Q9ES80, Q9ESF8
      UniProtKB/TrEMBL
      Q3TMA0, Q3UDP9
      Conserved Domains (1) summary
      cd17430
      Location:21 → 410
      MFS_MCT3_4; Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P57787.1 GenPept UniProtKB/Swiss-Prot:P57787

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous