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    Gcgr glucagon receptor [ Mus musculus (house mouse) ]

    Gene ID: 14527, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Gcgrprovided by MGI
    Official Full Name
    glucagon receptorprovided by MGI
    Primary source
    MGI:MGI:99572
    See related
    Ensembl:ENSMUSG00000025127 AllianceGenome:MGI:99572
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GR
    Summary
    Enables glucagon receptor activity. Involved in several processes, including cellular response to glucagon stimulus; glucose homeostasis; and regulation of glycogen metabolic process. Acts upstream of or within cellular response to starvation and positive regulation of gene expression. Is active in plasma membrane. Is expressed in several structures, including brain; foot mesenchyme; gut; liver; and male reproductive gland or organ. Used to study Mahvash Disease. Human ortholog(s) of this gene implicated in Mahvash Disease and type 2 diabetes mellitus. Orthologous to human GCGR (glucagon receptor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 145.3), liver E18 (RPKM 21.1) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gcgr in Genome Data Viewer
    Location:
    11 E2; 11 84.24 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120420011..120429815)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120529185..120538989)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39490 Neighboring gene predicted gene, 53658 Neighboring gene STARR-positive B cell enhancer ABC_E11502 Neighboring gene MAPK regulated corepressor interacting protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E8476 Neighboring gene protein phosphatase 1, regulatory subunit 27

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Chronic treatment with a glucagon receptor antagonist lowers glucose and moderately raises circulating glucagon and glucagon-like peptide 1 without severe alpha cell hypertrophy in diet-induced obese mice. Mu J, et al. Diabetologia, 2011 Sep. PMID 21695571
    2. Glucagon receptor knockout mice are resistant to diet-induced obesity and streptozotocin-mediated beta cell loss and hyperglycaemia. Conarello SL, et al. Diabetologia, 2007 Jan. PMID 17131145
    3. Glucagon receptor signaling is not required for N-carbamoyl glutamate- and l-citrulline-induced ureagenesis in mice. Galsgaard KD, et al. Am J Physiol Gastrointest Liver Physiol, 2020 May 1. PMID 32174131
    4. Hypoglycemia leads to age-related loss of vision. Umino Y, et al. Proc Natl Acad Sci U S A, 2006 Dec 19. PMID 17159157, Free PMC Article
    5. Glucagon receptor antagonism improves islet function in mice with insulin resistance induced by a high-fat diet. Winzell MS, et al. Diabetologia, 2007 Jul. PMID 17479245

    See all (121) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Downregulation of the kidney glucagon receptor, essential for renal function and systemic homeostasis, contributes to chronic kidney disease.
      Title: Downregulation of the kidney glucagon receptor, essential for renal function and systemic homeostasis, contributes to chronic kidney disease.
    2. Loss of endothelial glucocorticoid receptor accelerates organ fibrosis in db/db mice.
      Title: Loss of endothelial glucocorticoid receptor accelerates organ fibrosis in db/db mice.
    3. Glucagon receptor blockage inhibits beta-cell dedifferentiation through FoxO1.
      Title: Glucagon receptor blockage inhibits β-cell dedifferentiation through FoxO1.
    4. Glucagon receptor antagonism impairs and glucagon receptor agonism enhances triglycerides metabolism in mice.
      Title: Glucagon receptor antagonism impairs and glucagon receptor agonism enhances triglycerides metabolism in mice.
    5. Glucagon receptor signaling at white adipose tissue does not regulate lipolysis.
      Title: Glucagon receptor signaling at white adipose tissue does not regulate lipolysis.
    6. Intestinal Growth in Glucagon Receptor Knockout Mice Is Not Associated With the Formation of AOM/DSS-Induced Tumors.
      Title: Intestinal Growth in Glucagon Receptor Knockout Mice Is Not Associated With the Formation of AOM/DSS-Induced Tumors.
    7. Glucagon blockade restores functional beta-cell mass in type 1 diabetic mice and enhances function of human islets.
      Title: Glucagon blockade restores functional β-cell mass in type 1 diabetic mice and enhances function of human islets.
    8. The 14-3-3 protein YWHAB inhibits glucagon-induced hepatic gluconeogenesis through interacting with the glucagon receptor and FOXO1.
      Title: The 14-3-3 protein YWHAB inhibits glucagon-induced hepatic gluconeogenesis through interacting with the glucagon receptor and FOXO1.
    9. Glucagon receptor antagonism promotes the production of gut proglucagon-derived peptides in diabetic mice.
      Title: Glucagon receptor antagonism promotes the production of gut proglucagon-derived peptides in diabetic mice.
    10. Both glucagon-receptor signaling and insulin-receptor signaling mutually contribute to blood glucose homeostasis and amino acid metabolism in mice. Glucagon receptor antagonism increased amino acids, lowered glycemia, and increased glucagon but did not influence insulin concentrations.
      Title: Glucose and amino acid metabolism in mice depend mutually on glucagon and insulin receptor signaling.
    Submit: New GeneRIF Correction See all GeneRIFs (45)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glucagon receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucagon receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glucagon receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glucagon receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide hormone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide hormone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide hormone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to glucagon stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to glucagon stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hormone-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hormone-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of glycogen metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glucagon receptor
    Names
    GL-R

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431129.1 → NP_001418058.1  glucagon receptor isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL669855

    2. NM_008101.3 → NP_032127.2  glucagon receptor isoform 1 precursor

      See identical proteins and their annotated locations for NP_032127.2

      Status: VALIDATED

      Source sequence(s)
      AL669855
      Consensus CDS
      CCDS25739.1
      UniProtKB/Swiss-Prot
      Q61606, Q63960, Q8K0B5
      UniProtKB/TrEMBL
      Q3UN81
      Related
      ENSMUSP00000026119.8, ENSMUST00000026119.8
      Conserved Domains (2) summary
      cd15267
      Location:137 → 417
      7tmB1_GCGR; glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
      pfam02793
      Location:56 → 125
      HRM; Hormone receptor domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      120420011..120429815
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314269.2 → XP_017169758.1  glucagon receptor isoform X5

      UniProtKB/TrEMBL
      Q3UN81
      Conserved Domains (1) summary
      cd15267
      Location:143 → 373
      7tmB1_GCGR; glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

    2. XM_017314267.2 → XP_017169756.1  glucagon receptor isoform X3

      UniProtKB/TrEMBL
      Q3UN81
      Conserved Domains (1) summary
      cd15267
      Location:149 → 420
      7tmB1_GCGR; glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

    3. XM_017314263.2 → XP_017169752.1  glucagon receptor isoform X1

      UniProtKB/TrEMBL
      Q3UN81
      Conserved Domains (1) summary
      cd15267
      Location:149 → 429
      7tmB1_GCGR; glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

    4. XM_017314265.2 → XP_017169754.1  glucagon receptor isoform X1

      UniProtKB/TrEMBL
      Q3UN81
      Conserved Domains (1) summary
      cd15267
      Location:149 → 429
      7tmB1_GCGR; glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

    5. XM_017314268.2 → XP_017169757.1  glucagon receptor isoform X4

      UniProtKB/TrEMBL
      Q3UN81
      Conserved Domains (2) summary
      cd15267
      Location:108 → 388
      7tmB1_GCGR; glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
      pfam02793
      Location:27 → 96
      HRM; Hormone receptor domain

    6. XM_036156335.1 → XP_036012228.1  glucagon receptor isoform X6

      Conserved Domains (1) summary
      cd15267
      Location:1 → 280
      7tmB1_GCGR; glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

    7. XM_017314266.1 → XP_017169755.1  glucagon receptor isoform X2

      UniProtKB/Swiss-Prot
      Q61606, Q63960, Q8K0B5
      UniProtKB/TrEMBL
      Q3UN81
      Conserved Domains (2) summary
      cd15267
      Location:137 → 417
      7tmB1_GCGR; glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
      pfam02793
      Location:56 → 125
      HRM; Hormone receptor domain

    8. XM_006532216.4 → XP_006532279.1  glucagon receptor isoform X6

      Related
      ENSMUST00000147877.8
      Conserved Domains (1) summary
      cd15267
      Location:1 → 280
      7tmB1_GCGR; glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

    9. XM_030245567.1 → XP_030101427.1  glucagon receptor isoform X6

      Conserved Domains (1) summary
      cd15267
      Location:1 → 280
      7tmB1_GCGR; glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

    10. XM_006532217.2 → XP_006532280.1  glucagon receptor isoform X7

      Conserved Domains (2) summary
      cd14964
      Location:5 → 32
      7tm_GPCRs; TM helix 3 [structural motif]
      cl28897
      Location:1 → 196
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61606.2 GenPept UniProtKB/Swiss-Prot:Q61606

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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