Tax1bp3 Tax1 (human T cell leukemia virus type I) binding protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tax1bp3provided by MGI
Official Full Name: Tax1 (human T cell leukemia virus type I) binding protein 3provided by MGI
Primary source: MGI:MGI:1923531
See related: Ensembl:ENSMUSG00000040158 AllianceGenome:MGI:1923531
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TIP-1; 1300011C24Rik
Summary: Enables beta-catenin binding activity. Involved in negative regulation of Wnt signaling pathway. Acts upstream of or within negative regulation of cell population proliferation. Located in cytoplasm and nucleus. Is expressed in retina. Orthologous to human TAX1BP3 (Tax1 binding protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in large intestine adult (RPKM 94.1), colon adult (RPKM 65.9) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B4; 11 45.25 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (73067909..73072872)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (73177083..73182046)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Birc3 and Tip1 are upregulated in renal ischemia reperfusion injury.
Title: Birc3 and Tip1 are upregulated in renal ischemia reperfusion injury.
Tax1 binding protein 3 regulates osteogenic and adipogenic differentiation through inactivating Wnt/beta-catenin signalling.
Title: Tax1 binding protein 3 regulates osteogenic and adipogenic differentiation through inactivating Wnt/β-catenin signalling.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

D19424 (e-PCR)
- UniSTS:124812

NoName (e-PCR)
- UniSTS:493224

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables beta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in Rho protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in activation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein localization to cell surface	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tax1-binding protein 3

Names: tax interaction protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029564.2 → NP_083840.1 tax1-binding protein 3

Status: PROVISIONAL

Source sequence(s)

AK004963

Consensus CDS

CCDS25000.1

UniProtKB/Swiss-Prot

Q9DBG9

Related

ENSMUSP00000047410.6, ENSMUST00000040687.12

Conserved Domains (1) summary

cd00992
Location:13 → 109

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...