Fxr2 FMR1 autosomal homolog 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fxr2provided by MGI
Official Full Name: FMR1 autosomal homolog 2provided by MGI
Primary source: MGI:MGI:1346074
See related: Ensembl:ENSMUSG00000018765 AllianceGenome:MGI:1346074
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FXR2P; Fxr2h
Summary: Predicted to enable mRNA 3'-UTR binding activity; protein dimerization activity; and translation regulator activity. Involved in dentate gyrus development and mRNA destabilization. Located in dendrite and ribosome. Is active in cytoplasm; glutamatergic synapse; and postsynapse. Is expressed in central nervous system; female reproductive system; peripheral nervous system; sensory organ; and skin. Orthologous to human FXR2 (FMR1 autosomal homolog 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 38.9), CNS E14 (RPKM 36.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 42.86 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (69523788..69544123)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (69632971..69653297)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We discovered that FXR1P-deficient aNSCs have altered expression of a select number of cell-cycle genes, and we identified the mRNA of cyclin-dependent kinase inhibitor 1A (Cdkn1a, p21) as a direct target of FXR1P.
Title: Fragile X related protein 1 (FXR1P) regulates proliferation of adult neural stem cells.
Both Fmr1 and Fxr2 knockout mice have reduced fat deposits and glucose metabolism.
Title: The Fragile X proteins Fmrp and Fxr2p cooperate to regulate glucose metabolism in mice.
these findings show a coordinated regulation of PSD95/Dlg4 mRNA by FMRP and FXR2P that ultimately affects its fine-tuning during synaptic activity.
Title: FXR2P Exerts a Positive Translational Control and Is Required for the Activity-Dependent Increase of PSD95 Expression.
Differential regulation of SVZ and DG stem cells by FXR2 may be a key component of the mechanism that governs the different neurogenic processes in these two adult germinal.
Title: RNA-binding protein FXR2 regulates adult hippocampal neurogenesis by reducing Noggin expression.
FXR1P and FXR2P KH2 domains bind G-quadruplex and kissing complex RNA with the same affinity as the FMRP KH2 domain.
Title: Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs.
to unravel the function of Fxr2 protein, the expression pattern of 12,588 genes was studied in the brains of wild-type and Fxr2 knockout mice; genes and gene groups de-regulated in the brains of Fxr2 knockout mice were identified
Title: Genes and pathways differentially expressed in the brains of Fxr2 knockout mice.
Fxr2 regulates mammalian circadian behavioral rhythms.
Title: Fragile X-related proteins regulate mammalian circadian behavioral rhythms.
This protein shows high expression in brain and testis. The protein was tested in a behavioral test battery in knockout mice. The mice showed behavioral abnormalities.
Title: Knockout mouse model for Fxr2: a model for mental retardation.
Findings suggest that Fmr1 and Fxr2 genes contribute in a cooperative manner to pathways controlling locomotor activity, sensorimotor gating and cognitive processes.
Title: Exaggerated behavioral phenotypes in Fmr1/Fxr2 double knockout mice reveal a functional genetic interaction between Fragile X-related proteins.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-N93513 (e-PCR)
- UniSTS:1840

Fxr2 (e-PCR), detects polymorphism
- UniSTS:479112

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables translation regulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in animal organ development	IBA Inferred from Biological aspect of Ancestor more info
involved_in dentate gyrus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA destabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of long-term neuronal synaptic plasticity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mRNA stability	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in regulation of translation at presynapse, modulating synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic ribonucleoprotein granule	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasmic stress granule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in ribosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: RNA-binding protein FXR2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011814.2 → NP_035944.2 RNA-binding protein FXR2

See identical proteins and their annotated locations for NP_035944.2

Status: VALIDATED

Source sequence(s)

BC062971

Consensus CDS

CCDS24901.1

UniProtKB/Swiss-Prot

Q9WVR4, Q9WVR5

UniProtKB/TrEMBL

Q6P5B5

Related

ENSMUSP00000018909.4, ENSMUST00000018909.4

Conserved Domains (5) summary

smart00322
Location:230 → 290

KH; K homology RNA-binding domain

cd00105
Location:296 → 362

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam05641
Location:72 → 129

Agenet; Agenet domain

pfam12235
Location:364 → 482

FXMRP1_C_core; Fragile X-related 1 protein core C terminal

pfam16096
Location:512 → 579

FXR_C1; Fragile X-related 1 protein C-terminal region 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

69523788..69544123

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156681.1 → XP_036012574.1 RNA-binding protein FXR2 isoform X1

Conserved Domains (6) summary

pfam12235
Location:168 → 279

FXMRP1_C_core; Fragile X-related 1 protein core C terminal

pfam16096
Location:316 → 383

FXR_C1; Fragile X-related 1 protein C-terminal region 2

pfam17904
Location:1 → 21

KH_9; FMRP KH0 domain

NF033845
Location:247 → 467

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

cd22508
Location:32 → 94

KH_I_FXR2_rpt2; second type I K homology (KH) RNA-binding domain found in fragile X mental retardation syndrome-related protein 2 (FXR2) and similar proteins

cd22511
Location:95 → 172

KH_I_FXR2_rpt3; third type I K homology (KH) RNA-binding domain found in fragile X mental retardation syndrome-related protein 2 (FXR2) and similar proteins