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    Spock2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2 [ Mus musculus (house mouse) ]

    Gene ID: 94214, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spock2provided by MGI
    Official Full Name
    sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2provided by MGI
    Primary source
    MGI:MGI:1891351
    See related
    Ensembl:ENSMUSG00000058297 AllianceGenome:MGI:1891351
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gcap26; mKIAA0275
    Summary
    Enables extracellular matrix binding activity and glycosaminoglycan binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor; extracellular matrix organization; and positive regulation of cell-substrate adhesion. Located in collagen-containing extracellular matrix. Is expressed in Sertoli cell; brain; and germ cell of testis. Orthologous to human SPOCK2 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 116.0), cortex adult (RPKM 84.9) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Spock2 in Genome Data Viewer
    Location:
    10 B4; 10 29.69 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (59942079..59971020)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (60106257..60135198)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26792 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:59432972-59433155 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:59436913-59437130 Neighboring gene DNA-damage-inducible transcript 4 Neighboring gene STARR-positive B cell enhancer mm9_chr10:59460432-59460732 Neighboring gene anaphase promoting complex subunit 16 Neighboring gene activating signal cointegrator 1 complex subunit 1 Neighboring gene STARR-positive B cell enhancer ABC_E2937 Neighboring gene predicted gene, 51801 Neighboring gene microRNA 6906 Neighboring gene STARR-positive B cell enhancer ABC_E5138 Neighboring gene STARR-seq mESC enhancer starr_26799 Neighboring gene predicted gene, 51802 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:59631170-59631353 Neighboring gene STARR-positive B cell enhancer ABC_E10611 Neighboring gene STARR-positive B cell enhancer mm9_chr10:59652431-59652731 Neighboring gene STARR-positive B cell enhancer ABC_E11440 Neighboring gene carbohydrate sulfotransferase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Overexpression of Spock2 in mice leads to altered lung alveolar development and worsens lesions induced by hyperoxia. Hadchouel A, et al. Am J Physiol Lung Cell Mol Physiol, 2020 Jul 1. PMID 32374670
    2. Mouse testican-2. Expression, glycosylation, and effects on neurite outgrowth. Schnepp A, et al. J Biol Chem, 2005 Mar 25. PMID 15657052
    3. The novel prognostic marker SPOCK2 regulates tumour progression in melanoma. Kang JY, et al. Exp Dermatol, 2024 Jun. PMID 38888196
    4. Molecular cloning of testican-2: defining a novel calcium-binding proteoglycan family expressed in brain. Vannahme C, et al. J Neurochem, 1999 Jul. PMID 10386950
    5. Structural abnormalities of corpus callosum and cortical axonal tracts accompanied by decreased anxiety-like behavior and lowered sociability in spock3- mutant mice. Yamamoto A, et al. Dev Neurosci, 2014. PMID 25138526

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables collagen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellular matrix binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellular matrix binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables extracellular matrix structural constituent conferring compression resistance RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    enables glycosaminoglycan binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within extracellular matrix organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cell-substrate adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    testican-2
    Names
    granule cell antiserum positive 26

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_052994.2 → NP_443720.1  testican-2 precursor

      See identical proteins and their annotated locations for NP_443720.1

      Status: PROVISIONAL

      Source sequence(s)
      BC057324
      Consensus CDS
      CCDS35910.1
      UniProtKB/Swiss-Prot
      Q9ER58
      UniProtKB/TrEMBL
      F6SLR4
      Related
      ENSMUSP00000113115.3, ENSMUST00000121820.9
      Conserved Domains (4) summary
      smart00280
      Location:147 → 180
      KAZAL; Kazal type serine protease inhibitors
      cd00191
      Location:311 → 375
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:198 → 315
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam10591
      Location:197 → 302
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      59942079..59971020
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514347.5 → XP_006514410.1  testican-2 isoform X1

      UniProtKB/TrEMBL
      Q80U51
      Conserved Domains (4) summary
      cd00191
      Location:261 → 325
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:195 → 226
      EFh_SPARC_EC; EF-hand motif [structural motif]
      cl25349
      Location:149 → 259
      EFh_SPARC_EC; EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC)-like proteins
      pfam07648
      Location:84 → 130
      Kazal_2; Kazal-type serine protease inhibitor domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ER58.1 GenPept UniProtKB/Swiss-Prot:Q9ER58

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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