RIDA reactive intermediate imine deaminase A homolog [Homo sapiens (human)] - Gene

Summary

Official Symbol: RIDAprovided by HGNC
Official Full Name: reactive intermediate imine deaminase A homologprovided by HGNC
Primary source: HGNC:HGNC:16897
See related: Ensembl:ENSG00000132541 MIM:602487; AllianceGenome:HGNC:16897
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PSP; P14.5; UK114; HRSP12; hp14.5
Summary: Enables mRNA binding activity. Involved in mRNA catabolic process and mRNA destabilization. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in liver (RPKM 363.6), kidney (RPKM 202.2) and 3 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8q22.2

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (98102344..98117171, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (99227836..99242661, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (99114572..99129399, complement)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

P14.5 functions to inhibit cell migration and can be used as a prognostic marker in hepatocellular carcinoma.
Title: P14.5 functions to inhibit cell migration and can be used as a prognostic marker in hepatocellular carcinoma.
The new findings regarding the biological significance of enamine and imine production and outline the importance of RidA in controlling the accumulation of reactive metabolites.
Title: Reactive Enamines and Imines In Vivo: Lessons from the RidA Paradigm.
We also find that a subset of m(6)A-containing circular RNAs associates with YTHDF2 in an HRSP12-dependent manner and is selectively downregulated by RNase P/MRP.
Title: Endoribonucleolytic Cleavage of m(6)A-Containing RNAs by RNase P/MRP Complex.
Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
x-ray crystallography study of p14.5
Title: Crystal structure of Homo sapiens protein hp14.5.
analysis of ligand binding sites of protein p14.5
Title: Structure-based ligand binding sites of protein p14.5, a member of protein family YER057c/YIL051c/YjgF.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP. EBI GWAS Catalog EBI GWAS CatalogPubMed
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-T86935 (e-PCR)
- UniSTS:76356

RH66205 (e-PCR)
- UniSTS:80320

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 2-iminobutanoate deaminase activity	IEA Inferred from Electronic Annotation more info
enables 2-iminopropanoate deaminase activity	IEA Inferred from Electronic Annotation more info
enables RNA binding	HDA more info	PubMed
enables RNA endonuclease activity, producing 3'-phosphomonoesters	ISS Inferred from Sequence or Structural Similarity more info
enables deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables deaminase activity	TAS Traceable Author Statement more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in L-threonine catabolic process to glycine	TAS Traceable Author Statement more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in mRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA destabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of translation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HTP more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: 2-iminobutanoate/2-iminopropanoate deaminase

Names: 14.5 kDa translational inhibitor protein; UK114 antigen homolog; heat-responsive protein 12; perchloric acid-soluble protein; ribonuclease UK114; translation inhibitor L-PSP ribonuclease; translational inhibitor p14.5; translational inhibitor protein p14.5

NP_005827.1

EC 3.5.99.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.