U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    KIAA1614 KIAA1614 [ Homo sapiens (human) ]

    Gene ID: 57710, updated on 27-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    KIAA1614provided by HGNC
    Official Full Name
    KIAA1614provided by HGNC
    Primary source
    HGNC:HGNC:29327
    See related
    Ensembl:ENSG00000135835 AllianceGenome:HGNC:29327
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be involved in centrosome cycle; establishment or maintenance of cell polarity; and regulation of cellular localization. Predicted to be active in apical plasma membrane; cell cortex; and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 1.6), ovary (RPKM 1.5) and 22 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See KIAA1614 in Genome Data Viewer
    Location:
    1q25.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (180912897..180951614)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (180268104..180306855)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (180882033..180920750)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene xenotropic and polytropic retrovirus receptor 1 Neighboring gene uncharacterized LOC124904687 Neighboring gene MPRA-validated peak488 silencer Neighboring gene MPRA-validated peak489 silencer Neighboring gene uncharacterized LOC124904464 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:180866978-180867370 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:180868044-180868872 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1596 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2165 Neighboring gene long intergenic non-protein coding RNA 2816 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:180892213-180893094 Neighboring gene uncharacterized LOC107985231 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:180910063-180911042 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:180918561-180919111 Neighboring gene KIAA1614 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1597 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:180923653-180924258 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1598 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:180959945-180960105 Neighboring gene MPRA-validated peak491 silencer Neighboring gene major histocompatibility complex, class I-related pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:180991746-180992529 Neighboring gene syntaxin 6

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Identification of promoter regions in the human genome by using a retroviral plasmid library-based functional reporter gene assay. Khambata-Ford S, et al. Genome Res, 2003 Jul. PMID 12805274, Free PMC Article
    2. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2000 Aug 31. PMID 10997877
    3. Connecting the Dots in the Neuroglobin-Protein Interaction Network of an Unstressed and Ferroptotic Cell Death Neuroblastoma Model. Van Acker ZP, et al. Cells, 2019 Aug 11. PMID 31405213, Free PMC Article
    4. The sequence of the human genome. Venter JC, et al. Science, 2001 Feb 16. PMID 11181995
    5. Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D). Kennedy SA, et al. Nat Commun, 2020 Jan 24. PMID 31980649, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Potential readthrough

    Included gene: XPR1

    Homology

    Clone Names

    • FLJ32095

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in centrosome cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment or maintenance of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cellular localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    uncharacterized protein KIAA1614

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427641.1 → NP_001414570.1  uncharacterized protein KIAA1614 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL162431
      UniProtKB/TrEMBL
      A0AAQ5BGH9
      Related
      ENSP00000518922.1, ENST00000713624.1

    2. NM_020950.2 → NP_066001.1  uncharacterized protein KIAA1614 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AB046834, AL162431, DA410555, DA807788
      Consensus CDS
      CCDS41442.1
      UniProtKB/Swiss-Prot
      Q5VZ45, Q5VZ46, Q9HCF8
      Related
      ENSP00000356560.4, ENST00000367588.9
      Conserved Domains (1) summary
      pfam15737
      Location:354 → 478
      DUF4685; Domain of unknown function (DUF4685)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      180912897..180951614
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      180268104..180306855
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5VZ46.3 GenPept UniProtKB/Swiss-Prot:Q5VZ46

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools