Ulk4 unc-51-like kinase 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ulk4provided by MGI
Official Full Name: unc-51-like kinase 4provided by MGI
Primary source: MGI:MGI:1921622
See related: Ensembl:ENSMUSG00000040936 AllianceGenome:MGI:1921622
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A730098P15; 4932415A06Rik
Summary: Predicted to enable ATP binding activity; histone H2AS1 kinase activity; and protein serine kinase activity. Acts upstream of or within several processes, including adult walking behavior; cilium organization; and nervous system development. Is active in cilium. Is expressed in brain. Used to study hydrocephalus and schizophrenia. Orthologous to human ULK4 (unc-51 like kinase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 56.7) and ovary adult (RPKM 3.4) See more
Orthologs: human all
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Genomic context

Location:: 9 F4; 9 72.19 cM

Exon count:: 41

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (120793520..121115225, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (120964454..121286159, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ULK4 and Fused/STK36 interact to mediate assembly of a motile flagellum.
Title: ULK4 and Fused/STK36 interact to mediate assembly of a motile flagellum.
Deletion of Schizophrenia Susceptibility Gene Ulk4 Leads to Abnormal Cognitive Behaviors via Akt-GSK-3 Signaling Pathway in Mice.
Title: Deletion of Schizophrenia Susceptibility Gene Ulk4 Leads to Abnormal Cognitive Behaviors via Akt-GSK-3 Signaling Pathway in Mice.
Ulk4 +/tm1a mice exhibit anxiety-related phenotype.
Title: Ulk4 regulates GABAergic signaling and anxiety-related behavior.
This is the first evidence demonstrating that ULK4 is a crucial regulator of myelination, and ULK4 may therefore become a novel therapeutic target for hypomyelination diseases.
Title: Ulk4 deficiency leads to hypomyelination in mice.
Targeted disruption of the Ulk4 perturbed mid-neurogenesis and significantly reduced cerebral cortex in postnatal mice.
Title: Ulk4 Regulates Neural Stem Cell Pool.
This study showed that Ulk4 Is essential for Ciliogenesis and CSF Flow in mice
Title: Ulk4 Is Essential for Ciliogenesis and CSF Flow.
Congenital hydrocephalus with suppurative rhinosinusitis and otitis media in Ulk4 null mice indicative of primary ciliary dyskinesis
Title: Congenital hydrocephalus in genetically engineered mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:495104

D9Mit282 (e-PCR), detects polymorphism
- UniSTS:131850

NoName (e-PCR)
- UniSTS:224801

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within GABAergic neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within adult behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within adult walking behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axoneme assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within central nervous system myelination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebral cortex development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebrospinal fluid circulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ciliary basal body organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cognition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within corpus callosum development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dendritic spine development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within layer formation in cerebral cortex	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within memory	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within motile cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuroinflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuronal stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein kinase C deactivation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pyramidal neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neuron migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of p38MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of tau-protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory perception	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within smoothened signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within social behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ventricular system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine-protein kinase ULK4

NP_808257.2

EC 2.7.11.1

XP_006512086.1

EC 2.7.11.1

XP_006512087.1

EC 2.7.11.1

XP_006512088.1

EC 2.7.11.1

XP_006512089.1

EC 2.7.11.1

XP_011241254.1

EC 2.7.11.1

XP_017168752.1

EC 2.7.11.1

XP_030100042.1

EC 2.7.11.1

XP_030100043.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177589.3 → NP_808257.2 serine/threonine-protein kinase ULK4

Status: VALIDATED

Source sequence(s)

AK132731, AW456669, BC065094, BM938704

Consensus CDS

CCDS52967.1

UniProtKB/Swiss-Prot

Q2VP87, Q32LZ6, Q3V129, Q8BLS0, Q8C8Z5, Q9D4H6

UniProtKB/TrEMBL

E9Q2P5

Related

ENSMUSP00000131342.2, ENSMUST00000171923.8

Conserved Domains (1) summary

cd14010
Location:3 → 280

STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

120793520..121115225 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006512024.4 → XP_006512087.1 serine/threonine-protein kinase ULK4 isoform X1

See identical proteins and their annotated locations for XP_006512087.1

UniProtKB/Swiss-Prot

Q2VP87, Q32LZ6, Q3V129, Q8BLS0, Q8C8Z5, Q9D4H6

Conserved Domains (1) summary

cd14010
Location:3 → 280

STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4
XM_030244183.2 → XP_030100043.1 serine/threonine-protein kinase ULK4 isoform X2

UniProtKB/Swiss-Prot

Q2VP87, Q32LZ6, Q3V129, Q8BLS0, Q8C8Z5, Q9D4H6

UniProtKB/TrEMBL

E9Q2P5

Conserved Domains (1) summary

cd14010
Location:3 → 280

STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4
XM_030244182.1 → XP_030100042.1 serine/threonine-protein kinase ULK4 isoform X2

UniProtKB/Swiss-Prot

Q2VP87, Q32LZ6, Q3V129, Q8BLS0, Q8C8Z5, Q9D4H6

UniProtKB/TrEMBL

E9Q2P5

Conserved Domains (1) summary

cd14010
Location:3 → 280

STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4
XM_006512023.3 → XP_006512086.1 serine/threonine-protein kinase ULK4 isoform X1

See identical proteins and their annotated locations for XP_006512086.1

UniProtKB/Swiss-Prot

Q2VP87, Q32LZ6, Q3V129, Q8BLS0, Q8C8Z5, Q9D4H6

Conserved Domains (1) summary

cd14010
Location:3 → 280

STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4
XM_017313263.3 → XP_017168752.1 serine/threonine-protein kinase ULK4 isoform X1

UniProtKB/Swiss-Prot

Q2VP87, Q32LZ6, Q3V129, Q8BLS0, Q8C8Z5, Q9D4H6

Conserved Domains (1) summary

cd14010
Location:3 → 280

STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4
XM_006512025.5 → XP_006512088.1 serine/threonine-protein kinase ULK4 isoform X3

UniProtKB/Swiss-Prot

Q2VP87, Q32LZ6, Q3V129, Q8BLS0, Q8C8Z5, Q9D4H6

Conserved Domains (1) summary

cd14010
Location:3 → 280

STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4
XM_006512026.4 → XP_006512089.1 serine/threonine-protein kinase ULK4 isoform X5
XM_011242952.4 → XP_011241254.1 serine/threonine-protein kinase ULK4 isoform X4

Related

ENSMUSP00000129214.2, ENSMUST00000171061.8

Conserved Domains (1) summary

cd14010
Location:3 → 280

STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4