Dnah3 dynein, axonemal, heavy chain 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dnah3provided by MGI
Official Full Name: dynein, axonemal, heavy chain 3provided by MGI
Primary source: MGI:MGI:2683040
See related: Ensembl:ENSMUSG00000052273 AllianceGenome:MGI:2683040
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dnahc3
Summary: Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement involved in cell motility. Predicted to be located in microtubule. Predicted to be part of inner dynein arm. Predicted to be active in 9+2 motile cilium. Orthologous to human DNAH3 (dynein axonemal heavy chain 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 6.4), lung adult (RPKM 1.6) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 7 F2; 7 64.34 cM

Exon count:: 61

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (119520555..119694520, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (119921332..120095297, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables dynein intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein intermediate chain binding	IEA Inferred from Electronic Annotation more info
enables dynein light intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein light intermediate chain binding	IEA Inferred from Electronic Annotation more info
enables minus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables minus-end-directed microtubule motor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cilium movement involved in cell motility	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in 9+2 motile cilium	IBA Inferred from Biological aspect of Ancestor more info
part_of inner dynein arm	IBA Inferred from Biological aspect of Ancestor more info
part_of inner dynein arm	ISM Inferred from Sequence Model more info	PubMed
located_in microtubule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dynein axonemal heavy chain 3

Names: axonemal beta dynein heavy chain 3; ciliary dynein heavy chain 3; dynein heavy chain 3, axonemal; dynein, axonemal, heavy polypeptide 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001370806.1 → NP_001357735.1 dynein axonemal heavy chain 3

Status: VALIDATED

Source sequence(s)

AC122853, AC131702

Consensus CDS

CCDS90321.1

UniProtKB/Swiss-Prot

O08829, Q7TT83, Q8BW94

UniProtKB/TrEMBL

A0A140LIN9

Related

ENSMUSP00000146895.3, ENSMUST00000209154.3

Conserved Domains (5) summary

COG5245
Location:1018 → 3745

DYN1; Dynein, heavy chain [Cytoskeleton]

pfam08393
Location:824 → 1221

DHC_N2; Dynein heavy chain, N-terminal region 2

pfam12774
Location:1347 → 1673

AAA_6; Hydrolytic ATP binding site of dynein motor region D1

pfam12780
Location:2360 → 2620

AAA_8; P-loop containing dynein motor region D4

pfam18199
Location:3767 → 4068

Dynein_C; Dynein heavy chain C-terminal domain