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    Strip2 striatin interacting protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 320609, updated on 9-Dec-2024

    Summary

    Official Symbol
    Strip2provided by MGI
    Official Full Name
    striatin interacting protein 2provided by MGI
    Primary source
    MGI:MGI:2444363
    See related
    Ensembl:ENSMUSG00000039629 AllianceGenome:MGI:2444363
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam40b; Myoscape; D330017J20Rik
    Summary
    Predicted to be involved in cell migration; cytoskeleton organization; and regulation of cell shape. Predicted to be located in cytoplasm. Predicted to be part of FAR/SIN/STRIPAK complex. Predicted to be active in cytosol. Is expressed in brain and cochlea epithelium. Orthologous to human STRIP2 (striatin interacting protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 10.2), heart adult (RPKM 8.4) and 10 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Strip2 in Genome Data Viewer
    Location:
    6 A3.3; 6 12.36 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (29916975..29959680)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (29916976..29959681)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene smoothened, frizzled class receptor Neighboring gene predicted gene 13717 Neighboring gene STARR-positive B cell enhancer ABC_E677 Neighboring gene STARR-seq mESC enhancer starr_15451 Neighboring gene S-adenosylhomocysteine hydrolase-like 2 Neighboring gene STARR-positive B cell enhancer mm9_chr6:29783505-29783805 Neighboring gene STARR-positive B cell enhancer mm9_chr6:29787542-29787842 Neighboring gene STARR-positive B cell enhancer mm9_chr6:29788430-29788731 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:29847059-29847242 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:29847325-29847478 Neighboring gene STARR-positive B cell enhancer ABC_E4816 Neighboring gene predicted gene, 52897 Neighboring gene phosphoglycerate kinase 1 pseudogene Neighboring gene predicted gene, 24536

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA1170

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell shape ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of FAR/SIN/STRIPAK complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of FAR/SIN/STRIPAK complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    striatin-interacting proteins 2
    Names
    family with sequence similarity 40, member B
    protein FAM40B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037740.1NP_001032829.1  striatin-interacting proteins 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform (b) which is shorter than isoform a.
      Source sequence(s)
      AC079216, AK042073, AK122459
      Consensus CDS
      CCDS85025.1
      UniProtKB/TrEMBL
      E9QN41
      Related
      ENSMUSP00000119506.3, ENSMUST00000151738.4
      Conserved Domains (2) summary
      pfam07923
      Location:58348
      N1221; N1221-like protein
      pfam11882
      Location:466763
      DUF3402; Domain of unknown function (DUF3402)
    2. NM_177204.3NP_796178.2  striatin-interacting proteins 2 isoform a

      See identical proteins and their annotated locations for NP_796178.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC079216, AK042073
      Consensus CDS
      CCDS19967.1
      UniProtKB/Swiss-Prot
      Q3TQB7, Q80TI6, Q8C7A2, Q8C9H6
      UniProtKB/TrEMBL
      B2RW20
      Related
      ENSMUSP00000036477.7, ENSMUST00000046028.12
      Conserved Domains (2) summary
      pfam07923
      Location:58348
      N1221; N1221-like protein
      pfam11882
      Location:466791
      DUF3402; Domain of unknown function (DUF3402)

    RNA

    1. NR_104576.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK042073, AK052188, AK052273, BE988014

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      29916975..29959680
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505118.4XP_006505181.1  striatin-interacting proteins 2 isoform X1

      UniProtKB/TrEMBL
      E9QN41
      Conserved Domains (2) summary
      pfam07923
      Location:58348
      N1221; N1221-like protein
      pfam11882
      Location:466694
      DUF3402; Domain of unknown function (DUF3402)
    2. XM_011241067.2XP_011239369.1  striatin-interacting proteins 2 isoform X2

      See identical proteins and their annotated locations for XP_011239369.1

      UniProtKB/TrEMBL
      E9QN41
      Conserved Domains (2) summary
      pfam07923
      Location:58348
      N1221; N1221-like protein
      pfam11882
      Location:466635
      DUF3402; Domain of unknown function (DUF3402)
    3. XM_011241068.3XP_011239370.1  striatin-interacting proteins 2 isoform X2

      See identical proteins and their annotated locations for XP_011239370.1

      UniProtKB/TrEMBL
      E9QN41
      Related
      ENSMUSP00000110879.3, ENSMUST00000115224.8
      Conserved Domains (2) summary
      pfam07923
      Location:58348
      N1221; N1221-like protein
      pfam11882
      Location:466635
      DUF3402; Domain of unknown function (DUF3402)
    4. XM_011241069.2XP_011239371.1  striatin-interacting proteins 2 isoform X3

      Conserved Domains (2) summary
      pfam07923
      Location:60140
      N1221; N1221-like protein
      pfam11882
      Location:274600
      DUF3402; Domain of unknown function (DUF3402)