Dnali1 dynein, axonemal, light intermediate polypeptide 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dnali1provided by MGI
Official Full Name: dynein, axonemal, light intermediate polypeptide 1provided by MGI
Primary source: MGI:MGI:1922813
See related: Ensembl:ENSMUSG00000042707 AllianceGenome:MGI:1922813
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1700023A09Rik
Summary: Enables dynein heavy chain binding activity. Involved in sperm flagellum assembly. Located in several cellular components, including ciliary base; filopodium; and sperm flagellum. Is expressed in several structures, including brain ventricle and choroid plexus; choroid invagination; ependyma; epithelium; and testis. Human ortholog(s) of this gene implicated in spermatogenic failure 83. Orthologous to human DNALI1 (dynein axonemal light intermediate chain 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 82.2), ovary adult (RPKM 7.9) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 4 D2.2; 4 57.99 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (124949131..124959443, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (125055339..125065657, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DNALI1 deficiency causes male infertility with severe asthenozoospermia in humans and mice by disrupting the assembly of the flagellar inner dynein arms and fibrous sheath.
Title: DNALI1 deficiency causes male infertility with severe asthenozoospermia in humans and mice by disrupting the assembly of the flagellar inner dynein arms and fibrous sheath.
Dnali1 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
Title: Tissue expression patterns identify mouse cilia genes.
Results describe the gene encoding the dynein axonemal light intermediate chain Dnali1, and suggest that the C-terminal part of the cytoplasmic dynein heavy chain 1 is a putative interacting polypeptide of Dnali1.
Title: The murine Dnali1 gene encodes a flagellar protein that interacts with the cytoplasmic dynein heavy chain 1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

General gene information

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Markers

AW049135 (e-PCR)
- UniSTS:179060

NoName (e-PCR)
- UniSTS:488925

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables dynein heavy chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein heavy chain binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cilium movement	IC Inferred by Curator more info	PubMed
involved_in sperm flagellum assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sperm flagellum assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in 9+2 motile cilium	EXP Inferred from Experiment more info	PubMed
is_active_in axoneme	IBA Inferred from Biological aspect of Ancestor more info
located_in axoneme	IDA Inferred from Direct Assay more info	PubMed
located_in axoneme	ISO Inferred from Sequence Orthology more info
located_in ciliary base	EXP Inferred from Experiment more info	PubMed
is_active_in ciliary base	IBA Inferred from Biological aspect of Ancestor more info
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dynein axonemal particle	ISS Inferred from Sequence or Structural Similarity more info
part_of dynein complex	IEA Inferred from Electronic Annotation more info
located_in filopodium	IDA Inferred from Direct Assay more info	PubMed
located_in glial cell projection	EXP Inferred from Experiment more info	PubMed
located_in motile cilium	IDA Inferred from Direct Assay more info	PubMed
located_in motile cilium	ISO Inferred from Sequence Orthology more info
located_in motile cilium	ISS Inferred from Sequence or Structural Similarity more info
located_in sperm flagellum	IDA Inferred from Direct Assay more info	PubMed
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info
located_in sperm flagellum	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: axonemal dynein light intermediate polypeptide 1

Names: axonemal dynein light chain (hp28) homolog; inner dynein arm light chain, axonemal

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.