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    Pecam1 platelet/endothelial cell adhesion molecule 1 [ Mus musculus (house mouse) ]

    Gene ID: 18613, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pecam1provided by MGI
    Official Full Name
    platelet/endothelial cell adhesion molecule 1provided by MGI
    Primary source
    MGI:MGI:97537
    See related
    Ensembl:ENSMUSG00000020717 AllianceGenome:MGI:97537
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cd31; Pecam; PECAM-1
    Summary
    Predicted to enable protein homodimerization activity; protein phosphatase binding activity; and transmembrane signaling receptor activity. Acts upstream of or within several processes, including Rho protein signal transduction; endothelial cell morphogenesis; and positive regulation of tyrosine phosphorylation of STAT protein. Located in several cellular components, including cell-cell contact zone; external side of plasma membrane; and smooth muscle contractile fiber. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; extraembryonic component; and genitourinary system. Human ortholog(s) of this gene implicated in coronary artery disease; coronary stenosis; myocardial infarction; neuroblastoma; and psoriatic arthritis. Orthologous to human PECAM1 (platelet and endothelial cell adhesion molecule 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in lung adult (RPKM 94.3), subcutaneous fat pad adult (RPKM 41.1) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pecam1 in Genome Data Viewer
    Location:
    11 E1; 11 69.92 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (106545039..106606107, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (106654213..106715281, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22711 Neighboring gene nucleophosmin 1 pseudogene Neighboring gene testis expressed gene 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:106397706-106397815 Neighboring gene STARR-seq mESC enhancer starr_30931 Neighboring gene STARR-positive B cell enhancer ABC_E5288 Neighboring gene STARR-positive B cell enhancer ABC_E1150 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:106535909-106536110 Neighboring gene STARR-seq mESC enhancer starr_30943 Neighboring gene STARR-seq mESC enhancer starr_30946 Neighboring gene predicted gene, 51950 Neighboring gene STARR-positive B cell enhancer ABC_E10724 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:106611859-106612059 Neighboring gene STARR-positive B cell enhancer ABC_E5289 Neighboring gene STARR-positive B cell enhancer ABC_E4006 Neighboring gene mast cell immunoglobulin like receptor 1 Neighboring gene polymerase (DNA directed), gamma 2, accessory subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PECAM-1 modulates thrombin-induced tissue factor expression on endothelial cells. Zhang JJ, et al. J Cell Physiol, 2007 Feb. PMID 17111362
    2. The Ig-ITIM superfamily member PECAM-1 regulates the "outside-in" signaling properties of integrin alpha(IIb)beta3 in platelets. Wee JL, et al. Blood, 2005 Dec 1. PMID 16081692
    3. Platelet endothelial cell adhesion molecule-1 is a gatekeeper of neutrophil transendothelial migration in ischemic stroke. Winneberger J, et al. Brain Behav Immun, 2021 Mar. PMID 33388423
    4. Role of PECAM-1 in the shear-stress-induced activation of Akt and the endothelial nitric oxide synthase (eNOS) in endothelial cells. Fleming I, et al. J Cell Sci, 2005 Sep 15. PMID 16118242
    5. Endothelial targeting of a recombinant construct fusing a PECAM-1 single-chain variable antibody fragment (scFv) with prourokinase facilitates prophylactic thrombolysis in the pulmonary vasculature. Ding BS, et al. Blood, 2005 Dec 15. PMID 16144802, Free PMC Article

    See all (1000) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Effects of Nox4 upregulation on PECAM-1 expression in a mouse model of diabetic retinopathy.
      Title: Effects of Nox4 upregulation on PECAM-1 expression in a mouse model of diabetic retinopathy.
    2. Mechanotransduction via endothelial adhesion molecule CD31 initiates transmigration and reveals a role for VEGFR2 in diapedesis.
      Title: Mechanotransduction via endothelial adhesion molecule CD31 initiates transmigration and reveals a role for VEGFR2 in diapedesis.
    3. Platelet Endothelial Cell Adhesion Molecule (PECAM/CD31) Blockade Modulates Neutrophil Recruitment Patterns and Reduces Infarct Size in Experimental Ischemic Stroke.
      Title: Platelet Endothelial Cell Adhesion Molecule (PECAM/CD31) Blockade Modulates Neutrophil Recruitment Patterns and Reduces Infarct Size in Experimental Ischemic Stroke.
    4. CD31 signaling promotes the detachment at the uropod of extravasating neutrophils allowing their migration to sites of inflammation.
      Title: CD31 signaling promotes the detachment at the uropod of extravasating neutrophils allowing their migration to sites of inflammation.
    5. PIEZO1 and PECAM1 interact at cell-cell junctions and partner in endothelial force sensing.
      Title: PIEZO1 and PECAM1 interact at cell-cell junctions and partner in endothelial force sensing.
    6. Mice Lacking PECAM-1 and Ceacam1 Have Enhanced Platelet Secretion and Thrombus Growth: Novel Link with PAR4.
      Title: Mice Lacking PECAM-1 and Ceacam1 Have Enhanced Platelet Secretion and Thrombus Growth: Novel Link with PAR4.
    7. Inhibition of PECAM-1 Significantly Delays Leukocyte Extravasation into the Subcortex Post-Stroke.
      Title: Inhibition of PECAM-1 Significantly Delays Leukocyte Extravasation into the Subcortex Post-Stroke.
    8. Deficiency of Omentin-1 leads to delayed fracture healing through excessive inflammation and reduced CD31(hi)Emcn(hi) vessels.
      Title: Deficiency of Omentin-1 leads to delayed fracture healing through excessive inflammation and reduced CD31(hi)Emcn(hi) vessels.
    9. PECAM-1 supports leukocyte diapedesis by tension-dependent dephosphorylation of VE-cadherin.
      Title: PECAM-1 supports leukocyte diapedesis by tension-dependent dephosphorylation of VE-cadherin.
    10. Platelet endothelial cell adhesion molecule-1 is a gatekeeper of neutrophil transendothelial migration in ischemic stroke.
      Title: Platelet endothelial cell adhesion molecule-1 is a gatekeeper of neutrophil transendothelial migration in ischemic stroke.
    Submit: New GeneRIF Correction See all GeneRIFs (128)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: Polg2

    Homology

    Clone Names

    • MGC102160

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Rho protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in bicellular tight junction assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell-cell adhesion via plasma-membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion via plasma-membrane adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in diapedesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within endothelial cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within endothelial cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of endothelial barrier ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leukocyte cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monocyte extravasation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neutrophil extravasation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phagocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cellular extravasation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of leukocyte migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of tyrosine phosphorylation of STAT protein IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within wound healing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell-cell contact zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in smooth muscle contractile fiber IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    platelet endothelial cell adhesion molecule

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001032378.2 → NP_001027550.1  platelet endothelial cell adhesion molecule isoform 2 precursor

      See identical proteins and their annotated locations for NP_001027550.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a 3' coding exon but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
      Source sequence(s)
      AK169431, BC085502, BE692027, BY781761
      Consensus CDS
      CCDS25558.1
      UniProtKB/TrEMBL
      B1ARB3
      Related
      ENSMUSP00000099358.4, ENSMUST00000103069.10
      Conserved Domains (3) summary
      smart00410
      Location:33 → 117
      IG_like; Immunoglobulin like
      pfam13895
      Location:317 → 393
      Ig_2; Immunoglobulin domain
      cl11960
      Location:33 → 107
      Ig; Immunoglobulin domain

    2. NM_001305157.1 → NP_001292086.1  platelet endothelial cell adhesion molecule isoform 3 precursor

      See identical proteins and their annotated locations for NP_001292086.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 3' coding exon, which results in a frameshift, compared to variant 1. It encodes isoform 3 which has a longer and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK084527, AK169431, BE692027, BY781761
      Consensus CDS
      CCDS79069.1
      UniProtKB/Swiss-Prot
      B1ARB1, B1ARB2, Q08481, Q3TES6, Q922E0
      UniProtKB/TrEMBL
      B1ARB3
      Related
      ENSMUSP00000102408.3, ENSMUST00000106796.9
      Conserved Domains (3) summary
      smart00410
      Location:33 → 117
      IG_like; Immunoglobulin like
      pfam13895
      Location:317 → 393
      Ig_2; Immunoglobulin domain
      cl11960
      Location:33 → 107
      Ig; Immunoglobulin domain

    3. NM_001305158.1 → NP_001292087.1  platelet endothelial cell adhesion molecule isoform 4 precursor

      See identical proteins and their annotated locations for NP_001292087.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame 5' coding exon, and contains an alternate 3' coding exon which results in a frameshift, compared to variant 1. It encodes isoform 4 which is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK037551, AK084527, AK169431, BE692027, BY781761
      Consensus CDS
      CCDS79068.1
      UniProtKB/TrEMBL
      B1ARB3
      Related
      ENSMUSP00000138959.2, ENSMUST00000183610.8
      Conserved Domains (4) summary
      smart00410
      Location:33 → 117
      IG_like; Immunoglobulin like
      pfam00635
      Location:85 → 185
      Motile_Sperm; MSP (Major sperm protein) domain
      pfam13895
      Location:216 → 292
      Ig_2; Immunoglobulin domain
      cl11960
      Location:33 → 107
      Ig; Immunoglobulin domain

    4. NM_008816.3 → NP_032842.2  platelet endothelial cell adhesion molecule isoform 1 precursor

      See identical proteins and their annotated locations for NP_032842.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AK084527, BE692027, BY781761
      Consensus CDS
      CCDS25559.1
      UniProtKB/TrEMBL
      B1ARB3
      Related
      ENSMUSP00000079664.5, ENSMUST00000080853.11
      Conserved Domains (3) summary
      smart00410
      Location:33 → 117
      IG_like; Immunoglobulin like
      pfam13895
      Location:317 → 393
      Ig_2; Immunoglobulin domain
      cl11960
      Location:33 → 107
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      106545039..106606107 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08481.1 GenPept UniProtKB/Swiss-Prot:Q08481

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous