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    Clip4 CAP-GLY domain containing linker protein family, member 4 [ Mus musculus (house mouse) ]

    Gene ID: 78785, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Clip4provided by MGI
    Official Full Name
    CAP-GLY domain containing linker protein family, member 4provided by MGI
    Primary source
    MGI:MGI:1919100
    See related
    Ensembl:ENSMUSG00000024059 AllianceGenome:MGI:1919100
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rsnl2; 1700024K14Rik; 1700074B05Rik; 4833417L20Rik; 5830409B12Rik
    Summary
    Predicted to enable microtubule plus-end binding activity. Predicted to be involved in cytoplasmic microtubule organization. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in cell cortex; microtubule plus-end; and nucleus. Is expressed in bladder; trunk mesenchyme; and urethra. Orthologous to human CLIP4 (CAP-Gly domain containing linker protein family member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 58.9), heart adult (RPKM 24.2) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Clip4 in Genome Data Viewer
    Location:
    17 E1.3; 17 42.9 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (72076674..72171205)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (71769674..71864210)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10969 Neighboring gene TOG array regulator of axonemal microtubules 2 Neighboring gene STARR-seq mESC enhancer starr_43179 Neighboring gene photoreceptor cilium actin regulator Neighboring gene predicted gene, 30140 Neighboring gene STARR-seq mESC enhancer starr_43180 Neighboring gene anaplastic lymphoma kinase Neighboring gene STARR-seq mESC enhancer starr_43182 Neighboring gene predicted gene, 41613 Neighboring gene budding uninhibited by benzimidazoles 3 homolog pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule plus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CAP-Gly domain-containing linker protein 4
    Names
    restin-like protein 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271483.1 → NP_001258412.1  CAP-Gly domain-containing linker protein 4 isoform 3

      See identical proteins and their annotated locations for NP_001258412.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate 3' exon structure, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC154458, AK019516
      Consensus CDS
      CCDS89147.1
      UniProtKB/TrEMBL
      A0A2R8VJW4
      Related
      ENSMUSP00000154969.2, ENSMUST00000229874.2
      Conserved Domains (3) summary
      sd00045
      Location:153 → 184
      ANK; ANK repeat [structural motif]
      pfam01302
      Location:486 → 550
      CAP_GLY; CAP-Gly domain
      pfam12796
      Location:111 → 217
      Ank_2; Ankyrin repeats (3 copies)

    2. NM_001271484.1 → NP_001258413.1  CAP-Gly domain-containing linker protein 4 isoform 4

      See identical proteins and their annotated locations for NP_001258413.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate 3' exon structure, which results in a frameshift, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK029962, AK161301, AV260889
      Consensus CDS
      CCDS89148.1
      UniProtKB/TrEMBL
      Q3TTL7
      Related
      ENSMUSP00000154878.2, ENSMUST00000230333.2
      Conserved Domains (4) summary
      cd00204
      Location:98 → 252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam01302
      Location:487 → 550
      CAP_GLY; CAP-Gly domain
      pfam12796
      Location:111 → 217
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:153 → 184
      ANK; ANK repeat [structural motif]

    3. NM_030179.3 → NP_084455.2  CAP-Gly domain-containing linker protein 4 isoform 1

      See identical proteins and their annotated locations for NP_084455.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC154458, AC154569
      Consensus CDS
      CCDS37687.1
      UniProtKB/Swiss-Prot
      Q8BW09, Q8CI96, Q921Q4, Q9D2S6
      Related
      ENSMUSP00000024854.8, ENSMUST00000024854.9
      Conserved Domains (3) summary
      sd00045
      Location:153 → 184
      ANK; ANK repeat [structural motif]
      pfam01302
      Location:486 → 550
      CAP_GLY; CAP-Gly domain
      pfam12796
      Location:111 → 217
      Ank_2; Ankyrin repeats (3 copies)

    4. NM_175378.1 → NP_780587.1  CAP-Gly domain-containing linker protein 4 isoform 2

      See identical proteins and their annotated locations for NP_780587.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains multiple differences in the UTRs and coding region, one of which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC154458, AC154569
      Consensus CDS
      CCDS89149.1
      UniProtKB/Swiss-Prot
      Q8CI96
      Related
      ENSMUSP00000155140.2, ENSMUST00000229952.2
      Conserved Domains (3) summary
      sd00045
      Location:153 → 184
      ANK; ANK repeat [structural motif]
      pfam01302
      Location:439 → 503
      CAP_GLY; CAP-Gly domain
      pfam12796
      Location:111 → 217
      Ank_2; Ankyrin repeats (3 copies)

    RNA

    1. NR_073185.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains multiple differences compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC154458, AK029962
      Related
      ENSMUST00000230747.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      72076674..72171205
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250146.2 → XP_030106006.1  CAP-Gly domain-containing linker protein 4 isoform X2

      UniProtKB/TrEMBL
      A0A2R8VJW4
      Conserved Domains (3) summary
      sd00045
      Location:153 → 184
      ANK; ANK repeat [structural motif]
      pfam01302
      Location:486 → 550
      CAP_GLY; CAP-Gly domain
      pfam12796
      Location:111 → 217
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_006525144.4 → XP_006525207.1  CAP-Gly domain-containing linker protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006525207.1

      UniProtKB/Swiss-Prot
      Q8BW09, Q8CI96, Q921Q4, Q9D2S6
      Conserved Domains (3) summary
      sd00045
      Location:153 → 184
      ANK; ANK repeat [structural motif]
      pfam01302
      Location:486 → 550
      CAP_GLY; CAP-Gly domain
      pfam12796
      Location:111 → 217
      Ank_2; Ankyrin repeats (3 copies)

    3. XM_006525146.1 → XP_006525209.1  CAP-Gly domain-containing linker protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006525209.1

      UniProtKB/Swiss-Prot
      Q8BW09, Q8CI96, Q921Q4, Q9D2S6
      Conserved Domains (3) summary
      sd00045
      Location:153 → 184
      ANK; ANK repeat [structural motif]
      pfam01302
      Location:486 → 550
      CAP_GLY; CAP-Gly domain
      pfam12796
      Location:111 → 217
      Ank_2; Ankyrin repeats (3 copies)

    4. XM_006525145.5 → XP_006525208.1  CAP-Gly domain-containing linker protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006525208.1

      UniProtKB/Swiss-Prot
      Q8BW09, Q8CI96, Q921Q4, Q9D2S6
      Conserved Domains (3) summary
      sd00045
      Location:153 → 184
      ANK; ANK repeat [structural motif]
      pfam01302
      Location:486 → 550
      CAP_GLY; CAP-Gly domain
      pfam12796
      Location:111 → 217
      Ank_2; Ankyrin repeats (3 copies)

    5. XM_006525147.5 → XP_006525210.1  CAP-Gly domain-containing linker protein 4 isoform X2

      See identical proteins and their annotated locations for XP_006525210.1

      UniProtKB/TrEMBL
      A0A2R8VJW4
      Conserved Domains (3) summary
      sd00045
      Location:153 → 184
      ANK; ANK repeat [structural motif]
      pfam01302
      Location:486 → 550
      CAP_GLY; CAP-Gly domain
      pfam12796
      Location:111 → 217
      Ank_2; Ankyrin repeats (3 copies)

    6. XM_006525153.4 → XP_006525216.1  CAP-Gly domain-containing linker protein 4 isoform X7

      See identical proteins and their annotated locations for XP_006525216.1

      UniProtKB/TrEMBL
      A0A2R8VHV0
      Related
      ENSMUSP00000155653.2, ENSMUST00000229304.2
      Conserved Domains (3) summary
      sd00045
      Location:153 → 184
      ANK; ANK repeat [structural motif]
      pfam01302
      Location:285 → 349
      CAP_GLY; CAP-Gly domain
      pfam12796
      Location:111 → 217
      Ank_2; Ankyrin repeats (3 copies)

    7. XM_030250147.2 → XP_030106007.1  CAP-Gly domain-containing linker protein 4 isoform X4

      Conserved Domains (3) summary
      sd00045
      Location:153 → 184
      ANK; ANK repeat [structural motif]
      pfam01302
      Location:439 → 503
      CAP_GLY; CAP-Gly domain
      pfam12796
      Location:111 → 217
      Ank_2; Ankyrin repeats (3 copies)

    8. XM_006525143.5 → XP_006525206.1  CAP-Gly domain-containing linker protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006525206.1

      UniProtKB/Swiss-Prot
      Q8BW09, Q8CI96, Q921Q4, Q9D2S6
      Conserved Domains (3) summary
      sd00045
      Location:153 → 184
      ANK; ANK repeat [structural motif]
      pfam01302
      Location:486 → 550
      CAP_GLY; CAP-Gly domain
      pfam12796
      Location:111 → 217
      Ank_2; Ankyrin repeats (3 copies)

    9. XM_006525150.4 → XP_006525213.1  CAP-Gly domain-containing linker protein 4 isoform X5

      Conserved Domains (3) summary
      sd00045
      Location:153 → 184
      ANK; ANK repeat [structural motif]
      pfam01302
      Location:486 → 550
      CAP_GLY; CAP-Gly domain
      pfam12796
      Location:111 → 217
      Ank_2; Ankyrin repeats (3 copies)

    10. XM_006525151.4 → XP_006525214.1  CAP-Gly domain-containing linker protein 4 isoform X6

      UniProtKB/TrEMBL
      A0A2R8VHV0
      Conserved Domains (3) summary
      sd00045
      Location:153 → 184
      ANK; ANK repeat [structural motif]
      pfam01302
      Location:285 → 349
      CAP_GLY; CAP-Gly domain
      pfam12796
      Location:111 → 217
      Ank_2; Ankyrin repeats (3 copies)

    11. XM_036160848.1 → XP_036016741.1  CAP-Gly domain-containing linker protein 4 isoform X7

      UniProtKB/TrEMBL
      A0A2R8VHV0
      Conserved Domains (3) summary
      sd00045
      Location:153 → 184
      ANK; ANK repeat [structural motif]
      pfam01302
      Location:285 → 349
      CAP_GLY; CAP-Gly domain
      pfam12796
      Location:111 → 217
      Ank_2; Ankyrin repeats (3 copies)

    12. XM_006525148.5 → XP_006525211.1  CAP-Gly domain-containing linker protein 4 isoform X3

      See identical proteins and their annotated locations for XP_006525211.1

      Conserved Domains (3) summary
      sd00045
      Location:153 → 184
      ANK; ANK repeat [structural motif]
      pfam01302
      Location:439 → 503
      CAP_GLY; CAP-Gly domain
      pfam12796
      Location:111 → 217
      Ank_2; Ankyrin repeats (3 copies)

    13. XM_006525154.4 → XP_006525217.1  CAP-Gly domain-containing linker protein 4 isoform X8

      See identical proteins and their annotated locations for XP_006525217.1

      UniProtKB/Swiss-Prot
      Q8CI96
      Conserved Domains (3) summary
      sd00045
      Location:153 → 184
      ANK; ANK repeat [structural motif]
      pfam01302
      Location:439 → 503
      CAP_GLY; CAP-Gly domain
      pfam12796
      Location:111 → 217
      Ank_2; Ankyrin repeats (3 copies)

    RNA

    1. XR_385397.5 RNA Sequence

    2. XR_003952214.2 RNA Sequence

    3. XR_003952215.2 RNA Sequence

    4. XR_001782131.3 RNA Sequence

    5. XR_004939602.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CI96.1 GenPept UniProtKB/Swiss-Prot:Q8CI96

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