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    ethA monooxygenase EthA [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 886175, updated on 6-Oct-2023

    Summary

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    Gene symbol
    ethA
    Gene description
    monooxygenase EthA
    Locus tag
    Rv3854c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
    Also known as
    aka; etaA
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    Genomic context

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    Sequence:
    NC_000962.3 (4326004..4327473, complement)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene histone-like protein Hns Neighboring gene RNase E regulator RraA Neighboring gene HTH-type transcriptional repressor EthR Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Whole-Transcriptome and -Genome Analysis of Extensively Drug-Resistant Mycobacterium tuberculosis Clinical Isolates Identifies Downregulation of ethA as a Mechanism of Ethionamide Resistance. de Welzen L, et al. Antimicrob Agents Chemother, 2017 Dec. PMID 28993337, Free PMC Article
    2. Genotypic Analysis of Genes Associated with Independent Resistance and Cross-Resistance to Isoniazid and Ethionamide in Mycobacterium tuberculosis Clinical Isolates. Rueda J, et al. Antimicrob Agents Chemother, 2015 Dec. PMID 26369965, Free PMC Article
    3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
    4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
    5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Whole-transcriptome and -genome analysis of extensively drug-resistant Mycobacterium tuberculosis clinical isolates identifies downregulation of ethA as a mechanism of ethionamide resistance.
      Title: Whole-Transcriptome and -Genome Analysis of Extensively Drug-Resistant Mycobacterium tuberculosis Clinical Isolates Identifies Downregulation of ethA as a Mechanism of Ethionamide Resistance.
    2. The greatest rate of mutations causing ethionamide resistance were observed in katG, ethA, in mshA.
      Title: Genotypic Analysis of Genes Associated with Independent Resistance and Cross-Resistance to Isoniazid and Ethionamide in Mycobacterium tuberculosis Clinical Isolates.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    monooxygenase EthA
    NP_218371.1
    • FAD-containing

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      4326004..4327473 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_218371.1 monooxygenase EthA [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_218371.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A077D4A4, A0A077D8N2, A0A346TEP3, E7CT47, E7CT48, E7CT51, E7CT55
      Conserved Domains (1) summary
      COG2072
      Location:1 → 447
      CzcO; Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WNF9.1

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