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    hrp1 hypoxic response protein [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 888576, updated on 12-Jun-2021

    Summary

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    Gene symbol
    hrp1
    Gene description
    hypoxic response protein
    Locus tag
    Rv2626c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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    Genomic context

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    Sequence:
    NC_000962.3 (2952562..2952993, complement)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene universal stress protein Neighboring gene zinc metalloprotease Rip3 Neighboring gene hypothetical protein Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [Preliminary Study on the Secretory Performance of Mycobacterium tuberculosis Hypoxic Response Protein 1 (Rv2626c)]. Ni WY, et al. Sichuan Da Xue Xue Bao Yi Xue Ban, 2020 Sep. PMID 32975083
    2. Mycobacterium tuberculosis hypoxic response protein 1 (Hrp1) augments the pro-inflammatory response and enhances the survival of Mycobacterium smegmatis in murine macrophages. Sun C, et al. J Med Microbiol, 2017 Jul. PMID 28671529
    3. Chlamydial polymorphic membrane proteins: regulation, function and potential vaccine candidates. Vasilevsky S, et al. Virulence, 2016. PMID 26580416, Free PMC Article
    4. Mycobacterium tuberculosis conserved hypothetical protein rRv2626c modulates macrophage effector functions. Bashir N, et al. Immunology, 2010 May. PMID 20201990, Free PMC Article
    5. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. [Preliminary Study on the Secretory Performance of Mycobacterium tuberculosis Hypoxic Response Protein 1 (Rv2626c)].
      Title: [Preliminary Study on the Secretory Performance of Mycobacterium tuberculosis Hypoxic Response Protein 1 (Rv2626c)].
    2. Mycobacterium tuberculosis protein Rv2626c plays a significant role in stimulating macrophages to provoke a pro-inflammatory response and in mycobacterial survival during infection.
      Title: Mycobacterium tuberculosis hypoxic response protein 1 (Hrp1) augments the pro-inflammatory response and enhances the survival of Mycobacterium smegmatis in murine macrophages.
    3. PPE68 protein interacts and exports several unknown or known surface/secreted proteins, among them Rv2626c is associated with the host cell necrosis.
      Title: Chlamydial polymorphic membrane proteins: regulation, function and potential vaccine candidates.
    4. Rv2626c \appears to modulate macrophage effector functions by eliciting both innate and adaptive immune responses
      Title: Mycobacterium tuberculosis conserved hypothetical protein rRv2626c modulates macrophage effector functions.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    hypoxic response protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      2952562..2952993 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_217142.1 hypoxic response protein [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_217142.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P9WJA3
      UniProtKB/TrEMBL
      I6Y193
      Conserved Domains (1) summary
      cd04622
      Location:8 → 122
      CBS_pair_HRP1_like; CBS pair domain found in Hypoxic Response Protein 1 (HRP1) -like proteinds
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WJA3.1

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