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    dosT two component sensor histidine kinase DosT [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 888471, updated on 6-Aug-2024

    Summary

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    Gene symbol
    dosT
    Gene description
    two component sensor histidine kinase DosT
    Locus tag
    Rv2027c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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    Genomic context

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    Sequence:
    NC_000962.3 (2272787..2274508, complement)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene cation efflux system protein Neighboring gene universal stress protein Neighboring gene universal stress protein Neighboring gene 6-phosphofructokinase PfkB Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Strains of the East Asian (W/Beijing) lineage of Mycobacterium tuberculosis are DosS/DosT-DosR two-component regulatory system natural mutants. Fallow A, et al. J Bacteriol, 2010 Apr. PMID 20154135, Free PMC Article
    2. Mycobacterium tuberculosis DosS is a redox sensor and DosT is a hypoxia sensor. Kumar A, et al. Proc Natl Acad Sci U S A, 2007 Jul 10. PMID 17609369, Free PMC Article
    3. DosT and DevS are oxygen-switched kinases in Mycobacterium tuberculosis. Sousa EH, et al. Protein Sci, 2007 Aug. PMID 17600145, Free PMC Article
    4. Ultrafast ligand dynamics in the heme-based GAF sensor domains of the histidine kinases DosS and DosT from Mycobacterium tuberculosis. Vos MH, et al. Biochemistry, 2012 Jan 10. PMID 22142262, Free PMC Article
    5. Unique roles of DosT and DosS in DosR regulon induction and Mycobacterium tuberculosis dormancy. Honaker RW, et al. Infect Immun, 2009 Aug. PMID 19487478, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Despite their similarity, DosT and DosS histidine kinases display ligand-specific different primary dynamics during the initial phases of intraprotein signaling, in which the distal tyrosine, present in both proteins, plays an important role.
      Title: Ultrafast ligand dynamics in the heme-based GAF sensor domains of the histidine kinases DosS and DosT from Mycobacterium tuberculosis.
    2. Studies have revealed that the mutation in dosT alone is not directly responsible for the constitutive DosR regulon phenotype.
      Title: Strains of the East Asian (W/Beijing) lineage of Mycobacterium tuberculosis are DosS/DosT-DosR two-component regulatory system natural mutants.
    3. Both sensors DosS and DosT are necessary for wild-type levels of DosR regulon induction, and concomitantly, full induction of the regulon is required for wild-type anaerobic survival.
      Title: Unique roles of DosT and DosS in DosR regulon induction and Mycobacterium tuberculosis dormancy.
    4. This histidine-protein kinase, called DosT, is switched off by binding of oxygen to a heme. The affinity for O2 is Kd = 3 micro-molar. NO and CO will outcompete O2 for binding and blind DosT to O2 regulation.
      Title: DosT and DevS are oxygen-switched kinases in Mycobacterium tuberculosis.
    5. Heme-binding DosT kinase (Rv2027c) functions as a hypoxia sensor.
      Title: Mycobacterium tuberculosis DosS is a redox sensor and DosT is a hypoxia sensor.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    two component sensor histidine kinase DosT

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      2272787..2274508 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_216543.1 two component sensor histidine kinase DosT [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_216543.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0H3LA66
      Conserved Domains (2) summary
      COG2203
      Location:49 → 211
      FhlA; GAF domain [Signal transduction mechanisms]
      COG4585
      Location:327 → 572
      COG4585; Signal transduction histidine kinase [Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WGK1.1

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