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    esxH ESAT-6-like protein EsxH [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 886603, updated on 6-Oct-2023

    Summary

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    Gene symbol
    esxH
    Gene description
    ESAT-6-like protein EsxH
    Locus tag
    Rv0288
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
    Also known as
    cfp7; TB10.4
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    Genomic context

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    Sequence:
    NC_000962.3 (351848..352138)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene PPE family protein PPE4 Neighboring gene ESAT-6 like protein EsxG Neighboring gene ESX-3 secretion-associated protein EspG3 Neighboring gene ESX-3 secretion system protein EccD Neighboring gene membrane-anchored mycosin MycP

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A natural polymorphism of Mycobacterium tuberculosis in the esxH gene disrupts immunodomination by the TB10.4-specific CD8 T cell response. Sutiwisesak R, et al. PLoS Pathog, 2020 Oct. PMID 33075106, Free PMC Article
    2. Mycobacterium tuberculosis EsxH inhibits ESCRT-dependent CD4(+) T-cell activation. Portal-Celhay C, et al. Nat Microbiol, 2016 Dec 5. PMID 27918526, Free PMC Article
    3. Induction of CD8 T cells against a novel epitope in TB10.4: correlation with mycobacterial virulence and the presence of a functional region of difference-1. Billeskov R, et al. J Immunol, 2007 Sep 15. PMID 17785835
    4. Exchanging ESAT6 with TB10.4 in an Ag85B fusion molecule-based tuberculosis subunit vaccine: efficient protection and ESAT6-based sensitive monitoring of vaccine efficacy. Dietrich J, et al. J Immunol, 2005 May 15. PMID 15879133
    5. Molecular features governing the stability and specificity of functional complex formation by Mycobacterium tuberculosis CFP-10/ESAT-6 family proteins. Lightbody KL, et al. J Biol Chem, 2008 Jun 20. PMID 18430736

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A natural polymorphism of Mycobacterium tuberculosis in the esxH gene disrupts immunodomination by the TB10.4-specific CD8 T cell response.
      Title: A natural polymorphism of Mycobacterium tuberculosis in the esxH gene disrupts immunodomination by the TB10.4-specific CD8 T cell response.
    2. Here, the authors additionally show that ESCRT-III recruitment to sites of endolysosomal damage is antagonized by Mycobacterium tuberculosis EsxG and EsxH.
      Title: Mycobacterium tuberculosis Type VII Secretion System Effectors Differentially Impact the ESCRT Endomembrane Damage Response.
    3. Here, the authors showed that ESCRT is required for optimal antigen processing; correspondingly, overexpression and loss-of-function studies demonstrated that EsxH inhibited the ability of macrophages and dendritic cells to activate Mtb antigen-specific CD4(+) T cells.
      Title: Mycobacterium tuberculosis EsxH inhibits ESCRT-dependent CD4(+) T-cell activation.
    4. we identified an interaction between EsxH, which is secreted by the Esx-3 TSSS, and human hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs/Hrs), a component of the endosomal sorting complex required for transport (ESCRT).
      Title: Mycobacterium tuberculosis type VII secreted effector EsxH targets host ESCRT to impair trafficking.
    5. Solution structure of the Mycobacterium tuberculosis EsxG.EsxH complex: functional implications and comparisons with other M. tuberculosis Esx family complexes
      Title: Solution structure of the Mycobacterium tuberculosis EsxG·EsxH complex: functional implications and comparisons with other M. tuberculosis Esx family complexes.
    6. Sequenced the esxA, esxH, and fbpB genes of M. tuberculosis encoding ESAT-6, TB10.4, and Ag85B proteins, respectively, in a sample of 88 clinical isolates.
      Title: Assessment of the genetic diversity of Mycobacterium tuberculosis esxA, esxH, and fbpB genes among clinical isolates and its implication for the future immunization by new tuberculosis subunit vaccines Ag85B-ESAT-6 and Ag85B-TB10.4.
    7. analysis of the molecular basis for the specificity and stability of complex formation between CFP-10/ESAT-6 family proteins
      Title: Molecular features governing the stability and specificity of functional complex formation by Mycobacterium tuberculosis CFP-10/ESAT-6 family proteins.
    8. Mycobacterial epitope TB10.4(3-11)-specific CD8 T cells are induced in mice at the onset of infection with M. tuberculosis H37Rv and are present throughout the infection in high numbers.
      Title: Induction of CD8 T cells against a novel epitope in TB10.4: correlation with mycobacterial virulence and the presence of a functional region of difference-1.
    9. Vaccination with TB10.4 induces a significant protection against murine tuberculosis.
      Title: Exchanging ESAT6 with TB10.4 in an Ag85B fusion molecule-based tuberculosis subunit vaccine: efficient protection and ESAT6-based sensitive monitoring of vaccine efficacy.
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    General gene information

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    Homology

    General protein information

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    Preferred Names
    ESAT-6-like protein EsxH
    NP_214802.1
    • A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004 PMID:14766927). Predicted possible vaccine candidate (See Zvi et al.,2008).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      351848..352138
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_214802.1 ESAT-6-like protein EsxH [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_214802.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      G8EG85
      Conserved Domains (1) summary
      COG4842
      Location:1 → 96
      YukE; Uncharacterized conserved protein YukE [Function unknown]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WNK3.1

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