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    glcB malate synthase [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 885713, updated on 4-Feb-2024

    Summary

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    Gene symbol
    glcB
    Gene description
    malate synthase
    Locus tag
    Rv1837c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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    Genomic context

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    Sequence:
    NC_000962.3 (2084756..2086981, complement)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene serine esterase Neighboring gene hypothetical protein Neighboring gene ribonuclease VapC13 Neighboring gene PE-PGRS family protein PE_PGRS34 Neighboring gene antitoxin VapB13

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The product complex of M. tuberculosis malate synthase revisited. Anstrom DM, et al. Protein Sci, 2006 Aug. PMID 16877713, Free PMC Article
    2. Mycobacterium tuberculosis malate synthase- and MPT51-based serodiagnostic assay as an adjunct to rapid identification of pulmonary tuberculosis. Achkar JM, et al. Clin Vaccine Immunol, 2006 Nov. PMID 17090645, Free PMC Article
    3. Detection of Mycobacterium tuberculosis GlcB or HspX Antigens or devR DNA impacts the rapid diagnosis of tuberculous meningitis in children. Haldar S, et al. PLoS One, 2012. PMID 22984534, Free PMC Article
    4. Mycobacterium tuberculosis malate synthase is a laminin-binding adhesin. Kinhikar AG, et al. Mol Microbiol, 2006 May. PMID 16677310
    5. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. description of how detection of Mycobacterium tuberculosis GlcB or HspX Antigens or devR DNA impacts the rapid diagnosis of tuberculous meningitis in children
      Title: Detection of Mycobacterium tuberculosis GlcB or HspX Antigens or devR DNA impacts the rapid diagnosis of tuberculous meningitis in children.
    2. The revised position of bound malate is consistent with a reaction mechanism that does not require reorientation of the electrophilic substrate during the catalytic cycle, while the revised Mg(++) coordination is octahedral
      Title: The product complex of M. tuberculosis malate synthase revisited.
    3. Malate synthase- and MPT51-based serologic test serves as an adjunct to sputum microscopy in the rapid diagnosis of pulmonary tuberculosis.
      Title: Mycobacterium tuberculosis malate synthase- and MPT51-based serodiagnostic assay as an adjunct to rapid identification of pulmonary tuberculosis.
    4. Mycobacterium tuberculosis malate synthase (MS) has adapted to function as an adhesin which binds to laminin and fibronectin.
      Title: Mycobacterium tuberculosis malate synthase is a laminin-binding adhesin.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    General protein information

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    Preferred Names
    malate synthase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      2084756..2086981 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_216353.1 malate synthase [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_216353.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A654TMV3
      Conserved Domains (1) summary
      PRK02999
      Location:1 → 726
      PRK02999; malate synthase G; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    5H8P_A.1
    5H8U_A.1
    5H8U_B.1
    P9WK17.1

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