U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    glbN hemoglobin GlbN [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 886402, updated on 6-Oct-2023

    Summary

    Go to the top of the page Help
    Gene symbol
    glbN
    Gene description
    hemoglobin GlbN
    Locus tag
    Rv1542c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000962.3 (1744426..1744836, complement)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene lipoprotein signal peptidase Neighboring gene RNA pseudouridine synthase Neighboring gene lipoprotein LprI Neighboring gene oxidoreductase Neighboring gene ketoacyl reductase

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Direct Monitoring of the Reaction between Photochemically Generated Nitric Oxide and Mycobacterium tuberculosis Truncated Hemoglobin N Wild Type and Variant Forms: An Assessment of Computational Mechanistic Predictions. Koebke KJ, et al. Biochemistry, 2016 Feb 2. PMID 26757411
    2. Truncated hemoglobin, HbN, is post-translationally modified in Mycobacterium tuberculosis and modulates host-pathogen interactions during intracellular infection. Arya S, et al. J Biol Chem, 2013 Oct 11. PMID 23983123, Free PMC Article
    3. Structure and dynamics of Mycobacterium tuberculosis truncated hemoglobin N: insights from NMR spectroscopy and molecular dynamics simulations. Savard PY, et al. Biochemistry, 2011 Dec 27. PMID 21999759
    4. Structural characterization of the tunnels of Mycobacterium tuberculosis truncated hemoglobin N from molecular dynamics simulations. Daigle R, et al. Proteins, 2009 May 15. PMID 19003999
    5. Ligand binding to truncated hemoglobin N from Mycobacterium tuberculosis is strongly modulated by the interplay between the distal heme pocket residues and internal water. Ouellet YH, et al. J Biol Chem, 2008 Oct 3. PMID 18676995, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. trHbN boasts an extensive tunnel system that connects the protein exterior with the active site, which is likely the main contributor to the protein's impressive NO dioxygenation efficiency.
      Title: Direct Monitoring of the Reaction between Photochemically Generated Nitric Oxide and Mycobacterium tuberculosis Truncated Hemoglobin N Wild Type and Variant Forms: An Assessment of Computational Mechanistic Predictions.
    2. Data indicate that the truncated hemoglobin HbN remains glycosylated and membrane-localized and modulates host-pathogen interactions.
      Title: Truncated hemoglobin, HbN, is post-translationally modified in Mycobacterium tuberculosis and modulates host-pathogen interactions during intracellular infection.
    3. Data from solution heteronuclear relaxation NMR spectroscopy suggest that glbN is mainly rigid with some localized motions in distal heme pocket and along G-helix; data analysis included molecular dynamics simulations and trajectory analysis.
      Title: Structure and dynamics of Mycobacterium tuberculosis truncated hemoglobin N: insights from NMR spectroscopy and molecular dynamics simulations.
    4. Data lead to new and distinctly different conclusion on the impact of the Phe62(E15) residue on trHbN tunnels.
      Title: Structural characterization of the tunnels of Mycobacterium tuberculosis truncated hemoglobin N from molecular dynamics simulations.
    5. Ligand binding to truncated hemoglobin N from Mycobacterium tuberculosis is strongly modulated by the interplay between the distal heme pocket residues and internal water
      Title: Ligand binding to truncated hemoglobin N from Mycobacterium tuberculosis is strongly modulated by the interplay between the distal heme pocket residues and internal water.
    6. Our data strongly support the hypothesis that the access of NO to the heme cavity is dynamically regulated by the TyrB10-GlnE11 pair, which acts as a molecular switch that controls opening of the ligand diffusion tunnel.
      Title: Dynamical regulation of ligand migration by a gate-opening molecular switch in truncated hemoglobin-N from Mycobacterium tuberculosis.
    7. findings suggest that the functional processes of ligand binding and diffusion are controlled in truncated hemoglobin N through the dynamic interaction of residues Y(B10), Q(E11), F(E15), and the heme ligand
      Title: Ligand interactions in the distal heme pocket of Mycobacterium tuberculosis truncated hemoglobin N: roles of TyrB10 and GlnE11 residues.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    General protein information

    Go to the top of the page Help
    Preferred Names
    hemoglobin GlbN

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      1744426..1744836 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_216058.1 hemoglobin GlbN [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_216058.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2I7W6V1
      Conserved Domains (1) summary
      cd14756
      Location:17 → 127
      TrHb; Truncated Mb-fold globins, T family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WN25.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Miscellaneous