Pars2 prolyl-tRNA synthetase (mitochondrial)(putative) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pars2provided by MGI
Official Full Name: prolyl-tRNA synthetase (mitochondrial)(putative)provided by MGI
Primary source: MGI:MGI:2386296
See related: Ensembl:ENSMUSG00000043572 AllianceGenome:MGI:2386296
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable proline-tRNA ligase activity. Predicted to be involved in prolyl-tRNA aminoacylation. Located in mitochondrion. Is expressed in adrenal gland and gland. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 75. Orthologous to human PARS2 (prolyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 2.6), ovary adult (RPKM 2.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 C7; 4 49.67 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (106508266..106512479)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (106651069..106655282)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:546920

Pars2 (e-PCR), detects polymorphism
- UniSTS:546920

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables proline-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables proline-tRNA ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in prolyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in prolyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: probable proline--tRNA ligase, mitochondrial

Names: class II tRNA synthetase; proRS; probable prolyl-tRNA synthetase, mitochondrial; proline--tRNA ligase

NP_001077356.1

EC 6.1.1.15

NP_001272712.1

EC 6.1.1.15

NP_001272713.1

EC 6.1.1.15

NP_758476.2

EC 6.1.1.15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083887.2 → NP_001077356.1 probable proline--tRNA ligase, mitochondrial isoform 2

See identical proteins and their annotated locations for NP_001077356.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 2 and 3 encode the same isoform (2).

Source sequence(s)

AL929585

Consensus CDS

CCDS38828.1

UniProtKB/TrEMBL

A8Y5T6, Q3U4M2

Related

ENSMUSP00000102393.2, ENSMUST00000106781.2

Conserved Domains (3) summary

PRK09194
Location:78 → 506

PRK09194; prolyl-tRNA synthetase; Provisional

cd00779
Location:101 → 390

ProRS_core_prok; Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...

cd00861
Location:405 → 506

ProRS_anticodon_short; ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, ...
NM_001285783.1 → NP_001272712.1 probable proline--tRNA ligase, mitochondrial isoform 2

See identical proteins and their annotated locations for NP_001272712.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the longest transcript. Variants 2 and 3 encode the same isoform (2).

Source sequence(s)

AL929585, BB652093

Consensus CDS

CCDS38828.1

UniProtKB/TrEMBL

A8Y5T6, Q3U4M2

Conserved Domains (3) summary

PRK09194
Location:78 → 506

PRK09194; prolyl-tRNA synthetase; Provisional

cd00779
Location:101 → 390

ProRS_core_prok; Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...

cd00861
Location:405 → 506

ProRS_anticodon_short; ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, ...
NM_001285784.1 → NP_001272713.1 probable proline--tRNA ligase, mitochondrial isoform 1

See identical proteins and their annotated locations for NP_001272713.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and the 5' coding region and initiates translation at an alternate start codon, compared to variant 3. Variants 1 and 4 encode the same isoform (1), which is shorter at the N-terminus compared to isoform 2.

Source sequence(s)

AL929585, BB842735

Consensus CDS

CCDS18423.1

UniProtKB/Swiss-Prot

A2AVQ8, Q8CFI5, Q8R0C4

UniProtKB/TrEMBL

Q3U4M2

Conserved Domains (3) summary

PRK09194
Location:42 → 470

PRK09194; prolyl-tRNA synthetase; Provisional

cd00779
Location:65 → 354

ProRS_core_prok; Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...

cd00861
Location:369 → 470

ProRS_anticodon_short; ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, ...
NM_172272.2 → NP_758476.2 probable proline--tRNA ligase, mitochondrial isoform 1

See identical proteins and their annotated locations for NP_758476.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR and the 5' coding region and initiates translation at an alternate start codon, compared to variant 3. Variants 1 and 4 encode the same isoform (1), which is shorter at the N-terminus compared to isoform 2.

Source sequence(s)

AL929585, BY768753

Consensus CDS

CCDS18423.1

UniProtKB/Swiss-Prot

A2AVQ8, Q8CFI5, Q8R0C4

UniProtKB/TrEMBL

Q3U4M2

Related

ENSMUSP00000053160.8, ENSMUST00000058905.8

Conserved Domains (3) summary

PRK09194
Location:42 → 470

PRK09194; prolyl-tRNA synthetase; Provisional

cd00779
Location:65 → 354

ProRS_core_prok; Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...

cd00861
Location:369 → 470

ProRS_anticodon_short; ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, ...