Mbl1 mannose-binding lectin (protein A) 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mbl1provided by MGI
Official Full Name: mannose-binding lectin (protein A) 1provided by MGI
Primary source: MGI:MGI:96923
See related: Ensembl:ENSMUSG00000037780 AllianceGenome:MGI:96923
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MBL-A; MBP-A; S-MBP
Summary: Predicted to enable several functions, including D-mannose binding activity; calcium-dependent carbohydrate binding activity; and phosphatidylinositol-4-phosphate binding activity. Acts upstream of or within defense response to other organism and positive regulation of phagocytosis. Located in extracellular space. Orthologous to human MBL1P (mannose binding lectin 1, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver adult (RPKM 28.0), liver E18 (RPKM 18.6) and 2 other tissues See more
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Genomic context

Location:: 14 B; 14 22.36 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (40873413..40885861)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (41151456..41163904)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mannan-Binding Lectin Promotes Murine Graft-versus-Host Disease by Amplifying Lipopolysaccharide-Initiated Inflammation.
Title: Mannan-Binding Lectin Promotes Murine Graft-versus-Host Disease by Amplifying Lipopolysaccharide-Initiated Inflammation.
Mannose-binding lectin activates the nuclear factor-kappaB and renal inflammation in the progression of diabetic nephropathy.
Title: Mannose-binding lectin activates the nuclear factor-κB and renal inflammation in the progression of diabetic nephropathy.
Mannose-binding lectin promotes blood-brain barrier breakdown and exacerbates axonal damage after traumatic brain injury in mice.
Title: Mannose-binding lectin promotes blood-brain barrier breakdown and exacerbates axonal damage after traumatic brain injury in mice.
Specific contribution of mannose-binding lectin murine isoforms to brain ischemia/reperfusion injury.
Title: Specific contribution of mannose-binding lectin murine isoforms to brain ischemia/reperfusion injury.
Mannan-binding lectin promotes keratinocyte to produce CXCL1 and enhances neutrophil infiltration at the early stages of psoriasis.
Title: Mannan-binding lectin promotes keratinocyte to produce CXCL1 and enhances neutrophil infiltration at the early stages of psoriasis.
work shows that pathogenic fungi promote pancreatic ductal adenocarcinoma by driving the complement cascade through the activation of MBL
Title: The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL.
Our study provides comprehensive information regarding spatial and temporal expression of collectins (SP-A, SP-D and MBL-A) and their cellular sources in murine testis. Positive regulation by testosterone and alteration in their level upon LPS challenge are clues relevant to suggest their involvement in testicular immune privilege
Title: Testicular expression of SP-A, SP-D and MBL-A is positively regulated by testosterone and modulated by lipopolysaccharide.
this study shows that MBL-A expression is induced in the gut in response to Candida albicans sensing and is required for intestinal homeostasis and host defense against Candida albicans
Title: Role of mannose-binding lectin in intestinal homeostasis and fungal elimination.
Targeted deletion of Mbl1/2 causes differential levels of inflammation-related gene sets at baseline and after exposure to ozone and significantly reduces pulmonary inflammation, thus indicating an important innate immunomodulatory role of the Mbl1/2 genes.
Title: Effects of mannose-binding lectin on pulmonary gene expression and innate immune inflammatory response to ozone.
Data indicate that lysyl hydroxylase 3 is essential for the glucosyltion of mannan-binding lectin MBL-A.
Title: Lysyl hydroxylase 3 modifies lysine residues to facilitate oligomerization of mannan-binding lectin.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (7) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D-mannose binding	ISO Inferred from Sequence Orthology more info
enables D-mannose binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium-dependent carbohydrate binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent carbohydrate binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables oligosaccharide binding	ISO Inferred from Sequence Orthology more info
enables oligosaccharide binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-4-phosphate binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-4-phosphate binding	ISO Inferred from Sequence Orthology more info
enables polysaccharide binding	IEA Inferred from Electronic Annotation more info
enables polysaccharide binding	ISO Inferred from Sequence Orthology more info
enables protease binding	IEA Inferred from Electronic Annotation more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in complement activation, classical pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within complement activation, lectin pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within complement activation, lectin pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in complement activation, lectin pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to Gram-positive bacterium	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within killing by host of symbiont cells	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of phagocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of phagocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein homotrimerization	ISO Inferred from Sequence Orthology more info
involved_in protein homotrimerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in surfactant homeostasis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in multivesicular body	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: mannose-binding protein A

Names: mannan-binding protein; mannose binding lectin (A); mannose binding lectin, serum (A); ra-reactive factor polysaccharide-binding component p28B; raRF p28B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010775.2 → NP_034905.1 mannose-binding protein A precursor

See identical proteins and their annotated locations for NP_034905.1

Status: PROVISIONAL

Source sequence(s)

AC124400

Consensus CDS

CCDS26961.1

UniProtKB/Swiss-Prot

P39039, Q0P6H1

Related

ENSMUSP00000153147.2, ENSMUST00000225792.2

Conserved Domains (2) summary

cd03591
Location:127 → 237

CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)

pfam01391
Location:37 → 89

Collagen; Collagen triple helix repeat (20 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

40873413..40885861

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006518669.4 → XP_006518732.1 mannose-binding protein A isoform X1

See identical proteins and their annotated locations for XP_006518732.1

UniProtKB/Swiss-Prot

P39039, Q0P6H1

Conserved Domains (2) summary

cd03591
Location:127 → 237

CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)

pfam01391
Location:37 → 89

Collagen; Collagen triple helix repeat (20 copies)