Mrpl10 mitochondrial ribosomal protein L10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mrpl10provided by MGI
Official Full Name: mitochondrial ribosomal protein L10provided by MGI
Primary source: MGI:MGI:1333801
See related: Ensembl:ENSMUSG00000001445 AllianceGenome:MGI:1333801
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: L10mt; Rpml8; MRP-L8; 0610040E02Rik
Summary: Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to act upstream of or within ribosome biogenesis. Located in mitochondrion. Is expressed in several structures, including early conceptus; gonad; heart; liver; and metanephros. Orthologous to human MRPL10 (mitochondrial ribosomal protein L10). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 100.8), kidney adult (RPKM 56.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 60.69 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (96932408..96940039)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (97041582..97049213)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data describe the regulation of mitochondrial protein synthesis by the reversible acetylation of the mitochondrial ribosome and characterize MRPL10 as a novel substrate of the NAD(+)-dependent deacetylase, SIRT3.
Title: NAD+-dependent deacetylase SIRT3 regulates mitochondrial protein synthesis by deacetylation of the ribosomal protein MRPL10.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in mitochondrial translation	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within ribosome biogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	NAS Non-traceable Author Statement more info	PubMed
part_of mitochondrial large ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial large ribosomal subunit	ISO Inferred from Sequence Orthology more info
part_of mitochondrial large ribosomal subunit	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of mitochondrial large ribosomal subunit	NAS Non-traceable Author Statement more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: large ribosomal subunit protein uL10m

Names: 39S ribosomal protein L10, mitochondrial

NP_001344736.1

EC 3.6.5.3

NP_001344737.1

EC 3.6.5.3

NP_080430.1

EC 3.6.5.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357807.2 → NP_001344736.1 large ribosomal subunit protein uL10m isoform 2

Status: VALIDATED

Source sequence(s)

AK150774, BF458354, BI989554, BY127904, CD561609

Conserved Domains (1) summary

cl00376
Location:81 → 158

Ribosomal_L10_P0; Ribosomal protein L10 family; composed of the large subunit ribosomal protein called L10 in bacteria, P0 in eukaryotes, and L10e in archaea, as well as uncharacterized P0-like eukaryotic proteins. In all three kingdoms, L10 forms a tight complex with ...
NM_001357808.2 → NP_001344737.1 large ribosomal subunit protein uL10m isoform 3

Status: VALIDATED

Source sequence(s)

AK150774, BF458354, BY127904, CD561609

Conserved Domains (1) summary

cd05797
Location:1 → 134

Ribosomal_L10; Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein ...
NM_026154.3 → NP_080430.1 large ribosomal subunit protein uL10m isoform 1 precursor

See identical proteins and their annotated locations for NP_080430.1

Status: VALIDATED

Source sequence(s)

AK150774, BF458354, CD561609

Consensus CDS

CCDS25312.1

UniProtKB/Swiss-Prot

Q3TBW2, Q9CQD2

Related

ENSMUSP00000001485.4, ENSMUST00000001485.10

Conserved Domains (1) summary

cd05797
Location:81 → 228

Ribosomal_L10; Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein ...