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    GPRC5C G protein-coupled receptor class C group 5 member C [ Homo sapiens (human) ]

    Gene ID: 55890, updated on 10-Dec-2024

    Summary

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    Official Symbol
    GPRC5Cprovided by HGNC
    Official Full Name
    G protein-coupled receptor class C group 5 member Cprovided by HGNC
    Primary source
    HGNC:HGNC:13309
    See related
    Ensembl:ENSG00000170412 MIM:605949; AllianceGenome:HGNC:13309
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RAIG3; RAIG-3
    Summary
    The protein encoded by this gene is a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in kidney (RPKM 15.6), thyroid (RPKM 14.0) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GPRC5C in Genome Data Viewer
    Location:
    17q25.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (74432088..74451658)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (75322628..75342195)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (72428227..72447797)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904055 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72382905-72383799 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72390282-72390782 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72390783-72391283 Neighboring gene Sharpr-MPRA regulatory region 691 Neighboring gene RNA, 5S ribosomal pseudogene 448 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72420638-72421138 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72422872-72423636 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8932 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12705 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72440360-72440904 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72440905-72441448 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72448210-72449201 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72449202-72450192 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:72450947-72451617 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12706 Neighboring gene uncharacterized LOC124904056 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12707 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12709 Neighboring gene CD300a molecule Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12710 Neighboring gene uncharacterized LOC107985074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12711 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12712 Neighboring gene CD300 molecule like family member b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. GPRC5C drives branched-chain amino acid metabolism in leukemogenesis. Zhang YW, et al. Blood Adv, 2023 Dec 26. PMID 37639313, Free PMC Article
    2. Anti-diabetic action of all-trans retinoic acid and the orphan G protein coupled receptor GPRC5C in pancreatic β-cells. Amisten S, et al. Endocr J, 2017 Mar 31. PMID 28228611
    3. Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain. Bräuner-Osborne H, et al. Genomics, 2000 Apr 15. PMID 10783259
    4. Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C). Robbins MJ, et al. Genomics, 2000 Jul 1. PMID 10945465
    5. Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D. Bräuner-Osborne H, et al. Biochim Biophys Acta, 2001 Apr 16. PMID 11311935

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC131820

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    is_active_in extracellular exosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vesicle HDA PubMed 

    General protein information

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    Preferred Names
    G-protein coupled receptor family C group 5 member C
    Names
    orphan G-protein coupled receptor
    retinoic acid responsive gene protein
    retinoic acid-induced gene 3 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001366261.2 → NP_001353190.1  G-protein coupled receptor family C group 5 member C isoform c precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) encodes isoform c.
      Source sequence(s)
      AC079325
      Consensus CDS
      CCDS92388.1
      UniProtKB/TrEMBL
      A0A0C4DFY5, A8MXZ4
      Conserved Domains (1) summary
      cd15277
      Location:48 → 305
      7tmC_RAIG3_GPRC5C; retinoic acid-inducible orphan G-protein-coupled receptor 3; class C family of seven-transmembrane G protein-coupled receptors, group 5, member C

    2. NM_001366262.2 → NP_001353191.1  G-protein coupled receptor family C group 5 member C isoform a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode isoform a.
      Source sequence(s)
      AC079325
      Consensus CDS
      CCDS11699.2
      UniProtKB/Swiss-Prot
      B5BUN4, Q2NL85, Q9NQ84, Q9NZG5
      UniProtKB/TrEMBL
      A0A0C4DFY5
      Conserved Domains (1) summary
      cd15277
      Location:48 → 305
      7tmC_RAIG3_GPRC5C; retinoic acid-inducible orphan G-protein-coupled receptor 3; class C family of seven-transmembrane G protein-coupled receptors, group 5, member C

    3. NM_018653.5 → NP_061123.4  G-protein coupled receptor family C group 5 member C isoform a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode isoform a.
      Source sequence(s)
      AC079325
      Consensus CDS
      CCDS11699.2
      UniProtKB/Swiss-Prot
      B5BUN4, Q2NL85, Q9NQ84, Q9NZG5
      UniProtKB/TrEMBL
      A0A0C4DFY5
      Related
      ENSP00000376405.3, ENST00000392629.3
      Conserved Domains (1) summary
      cd15277
      Location:48 → 305
      7tmC_RAIG3_GPRC5C; retinoic acid-inducible orphan G-protein-coupled receptor 3; class C family of seven-transmembrane G protein-coupled receptors, group 5, member C

    4. NM_022036.4 → NP_071319.3  G-protein coupled receptor family C group 5 member C isoform a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform a. Variants 1, 2 and 4 encode isoform a.
      Source sequence(s)
      AC079325
      Consensus CDS
      CCDS11699.2
      UniProtKB/Swiss-Prot
      B5BUN4, Q2NL85, Q9NQ84, Q9NZG5
      UniProtKB/TrEMBL
      A0A0C4DFY5
      Related
      ENSP00000376403.2, ENST00000392627.7
      Conserved Domains (1) summary
      cd15277
      Location:48 → 305
      7tmC_RAIG3_GPRC5C; retinoic acid-inducible orphan G-protein-coupled receptor 3; class C family of seven-transmembrane G protein-coupled receptors, group 5, member C

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      74432088..74451658
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047436400.1 → XP_047292356.1  G-protein coupled receptor family C group 5 member C isoform X3

      UniProtKB/TrEMBL
      A0A0C4DFY5, A8MXZ4
      Related
      ENSP00000376404.3, ENST00000392628.7

    2. XM_047436398.1 → XP_047292354.1  G-protein coupled receptor family C group 5 member C isoform X1

      UniProtKB/TrEMBL
      A0A0C4DFY5

    3. XM_047436399.1 → XP_047292355.1  G-protein coupled receptor family C group 5 member C isoform X2

      UniProtKB/TrEMBL
      A0A0C4DFY5

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791806.1 Reference GRCh38.p14 PATCHES

      Range
      8536..28106
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333233.1 → XP_054189208.1  G-protein coupled receptor family C group 5 member C isoform X3

      UniProtKB/TrEMBL
      A0A0C4DFY5, A8MXZ4

    2. XM_054333231.1 → XP_054189206.1  G-protein coupled receptor family C group 5 member C isoform X1

      UniProtKB/TrEMBL
      A0A0C4DFY5

    3. XM_054333232.1 → XP_054189207.1  G-protein coupled receptor family C group 5 member C isoform X2

      UniProtKB/TrEMBL
      A0A0C4DFY5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      75322628..75342195
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316669.1 → XP_054172644.1  G-protein coupled receptor family C group 5 member C isoform X3

      UniProtKB/TrEMBL
      A0A0C4DFY5, A8MXZ4

    2. XM_054316667.1 → XP_054172642.1  G-protein coupled receptor family C group 5 member C isoform X1

      UniProtKB/TrEMBL
      A0A0C4DFY5

    3. XM_054316668.1 → XP_054172643.1  G-protein coupled receptor family C group 5 member C isoform X2

      UniProtKB/TrEMBL
      A0A0C4DFY5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NQ84.2 GenPept UniProtKB/Swiss-Prot:Q9NQ84

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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