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    PAWR pro-apoptotic WT1 regulator [ Homo sapiens (human) ]

    Gene ID: 5074, updated on 9-Dec-2024

    Summary

    Official Symbol
    PAWRprovided by HGNC
    Official Full Name
    pro-apoptotic WT1 regulatorprovided by HGNC
    Primary source
    HGNC:HGNC:8614
    See related
    Ensembl:ENSG00000177425 MIM:601936; AllianceGenome:HGNC:8614
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAR4; Par-4
    Summary
    This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases. [provided by RefSeq, Aug 2017]
    Expression
    Ubiquitous expression in endometrium (RPKM 8.7), thyroid (RPKM 5.9) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See PAWR in Genome Data Viewer
    Location:
    12q21.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (79584879..79690964, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (79563553..79669620, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (79978659..80084744, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene synaptotagmin 1 Neighboring gene microRNA 1252 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:79906476-79906976 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:79906977-79907477 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:79926619-79927119 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:79933315-79933826 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:79933827-79934340 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:79936391-79936902 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:79938953-79939466 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:79941058-79941786 Neighboring gene NOP56 ribonucleoprotein pseudogene 3 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:80048601-80049285 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4681 Neighboring gene PPP1R12A antisense RNA 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4682 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:80104382-80104890 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:80177965-80178557 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:80178558-80179149 Neighboring gene uncharacterized LOC124902974 Neighboring gene protein phosphatase 1 regulatory subunit 12A Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:80268321-80268858 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:80268859-80269395 Neighboring gene RNA, 5S ribosomal pseudogene 363

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Par-4 expression is upregulated by HIV-1 Tat in hippocampal neurons and participates at an early stage of Tat-induced neuronal apoptosis, suggesting Par-4 may be a mediator of neuronal apoptosis in HIV encephalitis PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables enzyme binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables leucine zipper domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of T cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of amyloid precursor protein biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of apoptotic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of cellular senescence IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of hydrogen peroxide-mediated programmed cell death IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    colocalizes_with actin filament ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    PRKC apoptosis WT1 regulator protein
    Names
    PRKC, apoptosis, WT1, regulator
    WT1-interacting protein
    prostate apoptosis response protein 4
    prostate apoptosis response protein PAR-4
    prostate apoptosis response-4
    transcriptional repressor PAR4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001354732.2NP_001341661.1  PRKC apoptosis WT1 regulator protein isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC027288, AC073569, AC073595
      Consensus CDS
      CCDS31863.1
      UniProtKB/Swiss-Prot
      O75796, Q6FHY9, Q8N700, Q96IZ0
      Conserved Domains (1) summary
      pfam05911
      Location:268327
      FPP; Filament-like plant protein, long coiled-coil
    2. NM_001354733.2NP_001341662.1  PRKC apoptosis WT1 regulator protein isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC073569, AC073595
    3. NM_002583.4NP_002574.2  PRKC apoptosis WT1 regulator protein isoform 1

      See identical proteins and their annotated locations for NP_002574.2

      Status: REVIEWED

      Source sequence(s)
      AC027288, BC007018, CN280333, U63809
      Consensus CDS
      CCDS31863.1
      UniProtKB/Swiss-Prot
      O75796, Q6FHY9, Q8N700, Q96IZ0
      Related
      ENSP00000328088.4, ENST00000328827.9
      Conserved Domains (1) summary
      pfam05911
      Location:268327
      FPP; Filament-like plant protein, long coiled-coil

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      79584879..79690964 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428916.1XP_047284872.1  PRKC apoptosis WT1 regulator protein isoform X1

      UniProtKB/Swiss-Prot
      O75796, Q6FHY9, Q8N700, Q96IZ0
    2. XM_047428918.1XP_047284874.1  PRKC apoptosis WT1 regulator protein isoform X2

    3. XM_047428917.1XP_047284873.1  PRKC apoptosis WT1 regulator protein isoform X2

    4. XM_017019378.2XP_016874867.1  PRKC apoptosis WT1 regulator protein isoform X3

    5. XM_047428919.1XP_047284875.1  PRKC apoptosis WT1 regulator protein isoform X3

    6. XM_017019379.2XP_016874868.1  PRKC apoptosis WT1 regulator protein isoform X4

    RNA

    1. XR_944561.3 RNA Sequence

    2. XR_944560.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      79563553..79669620 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372151.1XP_054228126.1  PRKC apoptosis WT1 regulator protein isoform X1

      UniProtKB/Swiss-Prot
      O75796, Q6FHY9, Q8N700, Q96IZ0
    2. XM_054372152.1XP_054228127.1  PRKC apoptosis WT1 regulator protein isoform X2

    3. XM_054372153.1XP_054228128.1  PRKC apoptosis WT1 regulator protein isoform X3

    4. XM_054372154.1XP_054228129.1  PRKC apoptosis WT1 regulator protein isoform X4

    RNA

    1. XR_008488595.1 RNA Sequence

    2. XR_008488594.1 RNA Sequence