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    TDRKH tudor and KH domain containing [ Homo sapiens (human) ]

    Gene ID: 11022, updated on 3-Dec-2024

    Summary

    Official Symbol
    TDRKHprovided by HGNC
    Official Full Name
    tudor and KH domain containingprovided by HGNC
    Primary source
    HGNC:HGNC:11713
    See related
    Ensembl:ENSG00000182134 MIM:609501; AllianceGenome:HGNC:11713
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TDRD2
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in several processes, including P granule organization; male meiotic nuclear division; and piRNA processing. Located in mitochondrion. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 11.8), brain (RPKM 4.0) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TDRKH in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (151766486..151790534, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (150889872..150914019, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151744044..151763010, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S11 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1724 Neighboring gene mitochondrial ribosomal protein L9 Neighboring gene ornithine decarboxylase antizyme 3 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:151741546-151742242 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:151742243-151742937 Neighboring gene chloride nucleotide-sensitive channel 1A pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1326 Neighboring gene TDRKH antisense RNA 1 Neighboring gene leucine rich repeat and Ig domain containing 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in P granule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fertilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in male meiotic nuclear division ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in piRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in piRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in P granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion HTP PubMed 
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in pi-body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in piP-body ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    tudor and KH domain-containing protein
    Names
    putative RNA binding protein
    tudor domain containing 2
    tudor domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083963.1NP_001077432.1  tudor and KH domain-containing protein isoform a

      See identical proteins and their annotated locations for NP_001077432.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode isoform a.
      Source sequence(s)
      AK226092, BC022467, DA796638
      Consensus CDS
      CCDS41394.1
      UniProtKB/Swiss-Prot
      D3DV24, Q5SZR3, Q5SZR5, Q8N582, Q9NYV5, Q9Y2W6
      UniProtKB/TrEMBL
      B4DZR8
      Related
      ENSP00000395718.2, ENST00000458431.6
      Conserved Domains (4) summary
      cd04508
      Location:357404
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      cd00105
      Location:54116
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00567
      Location:303422
      TUDOR; Tudor domain
      pfam10573
      Location:192249
      UPF0561; uncharacterized protein family UPF0561
    2. NM_001083964.1NP_001077433.1  tudor and KH domain-containing protein isoform b

      See identical proteins and their annotated locations for NP_001077433.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate inframe segment in the coding region compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AK226092, BC022467, DA796638
      Consensus CDS
      CCDS41395.1
      UniProtKB/TrEMBL
      B4DZR8
      Related
      ENSP00000357817.3, ENST00000368825.7
      Conserved Domains (4) summary
      cd04508
      Location:312359
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      pfam00013
      Location:54112
      KH_1; KH domain
      pfam00567
      Location:258377
      TUDOR; Tudor domain
      pfam10573
      Location:147204
      UPF0561; uncharacterized protein family UPF0561
    3. NM_001083965.2NP_001077434.1  tudor and KH domain-containing protein isoform a

      See identical proteins and their annotated locations for NP_001077434.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, and 3 all encode isoform a.
      Source sequence(s)
      AF227192, AK226092, AL589765, BC022467, DA796638
      Consensus CDS
      CCDS41394.1
      UniProtKB/Swiss-Prot
      D3DV24, Q5SZR3, Q5SZR5, Q8N582, Q9NYV5, Q9Y2W6
      UniProtKB/TrEMBL
      B4DZR8
      Related
      ENSP00000357815.3, ENST00000368824.8
      Conserved Domains (4) summary
      cd04508
      Location:357404
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      cd00105
      Location:54116
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00567
      Location:303422
      TUDOR; Tudor domain
      pfam10573
      Location:192249
      UPF0561; uncharacterized protein family UPF0561
    4. NM_006862.4NP_006853.2  tudor and KH domain-containing protein isoform a

      See identical proteins and their annotated locations for NP_006853.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. Variants 1, 2, and 3 all encode isoform a.
      Source sequence(s)
      AF119121, AL589765, BC032690, DA796638
      Consensus CDS
      CCDS41394.1
      UniProtKB/Swiss-Prot
      D3DV24, Q5SZR3, Q5SZR5, Q8N582, Q9NYV5, Q9Y2W6
      UniProtKB/TrEMBL
      B4DZR8
      Related
      ENSP00000357819.6, ENST00000368827.10
      Conserved Domains (4) summary
      cd04508
      Location:357404
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      cd00105
      Location:54116
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00567
      Location:303422
      TUDOR; Tudor domain
      pfam10573
      Location:192249
      UPF0561; uncharacterized protein family UPF0561

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      151766486..151790534 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047441989.1XP_047297945.1  tudor and KH domain-containing protein isoform X1

      UniProtKB/Swiss-Prot
      D3DV24, Q5SZR3, Q5SZR5, Q8N582, Q9NYV5, Q9Y2W6
      UniProtKB/TrEMBL
      B4DZR8
    2. XM_047442008.1XP_047297964.1  tudor and KH domain-containing protein isoform X1

      UniProtKB/Swiss-Prot
      D3DV24, Q5SZR3, Q5SZR5, Q8N582, Q9NYV5, Q9Y2W6
      UniProtKB/TrEMBL
      B4DZR8
    3. XM_017000123.3XP_016855612.1  tudor and KH domain-containing protein isoform X1

      UniProtKB/Swiss-Prot
      D3DV24, Q5SZR3, Q5SZR5, Q8N582, Q9NYV5, Q9Y2W6
      UniProtKB/TrEMBL
      B4DZR8
      Conserved Domains (4) summary
      cd04508
      Location:357404
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      cd00105
      Location:54116
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00567
      Location:303422
      TUDOR; Tudor domain
      pfam10573
      Location:192249
      UPF0561; uncharacterized protein family UPF0561
    4. XM_017000126.2XP_016855615.1  tudor and KH domain-containing protein isoform X1

      UniProtKB/Swiss-Prot
      D3DV24, Q5SZR3, Q5SZR5, Q8N582, Q9NYV5, Q9Y2W6
      UniProtKB/TrEMBL
      B4DZR8
      Conserved Domains (4) summary
      cd04508
      Location:357404
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      cd00105
      Location:54116
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00567
      Location:303422
      TUDOR; Tudor domain
      pfam10573
      Location:192249
      UPF0561; uncharacterized protein family UPF0561
    5. XM_017000127.2XP_016855616.1  tudor and KH domain-containing protein isoform X1

      UniProtKB/Swiss-Prot
      D3DV24, Q5SZR3, Q5SZR5, Q8N582, Q9NYV5, Q9Y2W6
      UniProtKB/TrEMBL
      B4DZR8
      Conserved Domains (4) summary
      cd04508
      Location:357404
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      cd00105
      Location:54116
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00567
      Location:303422
      TUDOR; Tudor domain
      pfam10573
      Location:192249
      UPF0561; uncharacterized protein family UPF0561
    6. XM_017000128.2XP_016855617.1  tudor and KH domain-containing protein isoform X2

      UniProtKB/TrEMBL
      B4DJ68
      Conserved Domains (2) summary
      cd04508
      Location:133180
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      pfam00567
      Location:79198
      TUDOR; Tudor domain
    7. XM_017000124.2XP_016855613.1  tudor and KH domain-containing protein isoform X1

      UniProtKB/Swiss-Prot
      D3DV24, Q5SZR3, Q5SZR5, Q8N582, Q9NYV5, Q9Y2W6
      UniProtKB/TrEMBL
      B4DZR8
      Conserved Domains (4) summary
      cd04508
      Location:357404
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      cd00105
      Location:54116
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00567
      Location:303422
      TUDOR; Tudor domain
      pfam10573
      Location:192249
      UPF0561; uncharacterized protein family UPF0561
    8. XM_017000125.2XP_016855614.1  tudor and KH domain-containing protein isoform X1

      UniProtKB/Swiss-Prot
      D3DV24, Q5SZR3, Q5SZR5, Q8N582, Q9NYV5, Q9Y2W6
      UniProtKB/TrEMBL
      B4DZR8
      Related
      ENSP00000357812.1, ENST00000368822.5
      Conserved Domains (4) summary
      cd04508
      Location:357404
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      cd00105
      Location:54116
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00567
      Location:303422
      TUDOR; Tudor domain
      pfam10573
      Location:192249
      UPF0561; uncharacterized protein family UPF0561
    9. XM_017000122.3XP_016855611.1  tudor and KH domain-containing protein isoform X1

      UniProtKB/Swiss-Prot
      D3DV24, Q5SZR3, Q5SZR5, Q8N582, Q9NYV5, Q9Y2W6
      UniProtKB/TrEMBL
      B4DZR8
      Conserved Domains (4) summary
      cd04508
      Location:357404
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      cd00105
      Location:54116
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00567
      Location:303422
      TUDOR; Tudor domain
      pfam10573
      Location:192249
      UPF0561; uncharacterized protein family UPF0561

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      150889872..150914019 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333965.1XP_054189940.1  tudor and KH domain-containing protein isoform X1

      UniProtKB/Swiss-Prot
      D3DV24, Q5SZR3, Q5SZR5, Q8N582, Q9NYV5, Q9Y2W6
      UniProtKB/TrEMBL
      B4DZR8
    2. XM_054333966.1XP_054189941.1  tudor and KH domain-containing protein isoform X1

      UniProtKB/Swiss-Prot
      D3DV24, Q5SZR3, Q5SZR5, Q8N582, Q9NYV5, Q9Y2W6
      UniProtKB/TrEMBL
      B4DZR8
    3. XM_054333963.1XP_054189938.1  tudor and KH domain-containing protein isoform X1

      UniProtKB/Swiss-Prot
      D3DV24, Q5SZR3, Q5SZR5, Q8N582, Q9NYV5, Q9Y2W6
      UniProtKB/TrEMBL
      B4DZR8
    4. XM_054333967.1XP_054189942.1  tudor and KH domain-containing protein isoform X1

      UniProtKB/Swiss-Prot
      D3DV24, Q5SZR3, Q5SZR5, Q8N582, Q9NYV5, Q9Y2W6
      UniProtKB/TrEMBL
      B4DZR8
    5. XM_054333968.1XP_054189943.1  tudor and KH domain-containing protein isoform X1

      UniProtKB/Swiss-Prot
      D3DV24, Q5SZR3, Q5SZR5, Q8N582, Q9NYV5, Q9Y2W6
      UniProtKB/TrEMBL
      B4DZR8
    6. XM_054333969.1XP_054189944.1  tudor and KH domain-containing protein isoform X2

      UniProtKB/TrEMBL
      B4DJ68
    7. XM_054333962.1XP_054189937.1  tudor and KH domain-containing protein isoform X1

      UniProtKB/Swiss-Prot
      D3DV24, Q5SZR3, Q5SZR5, Q8N582, Q9NYV5, Q9Y2W6
      UniProtKB/TrEMBL
      B4DZR8
    8. XM_054333964.1XP_054189939.1  tudor and KH domain-containing protein isoform X1

      UniProtKB/Swiss-Prot
      D3DV24, Q5SZR3, Q5SZR5, Q8N582, Q9NYV5, Q9Y2W6
      UniProtKB/TrEMBL
      B4DZR8
    9. XM_054333961.1XP_054189936.1  tudor and KH domain-containing protein isoform X1

      UniProtKB/Swiss-Prot
      D3DV24, Q5SZR3, Q5SZR5, Q8N582, Q9NYV5, Q9Y2W6
      UniProtKB/TrEMBL
      B4DZR8