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    NGB neuroglobin [ Homo sapiens (human) ]

    Gene ID: 58157, updated on 27-Nov-2024

    Summary

    Official Symbol
    NGBprovided by HGNC
    Official Full Name
    neuroglobinprovided by HGNC
    Primary source
    HGNC:HGNC:14077
    See related
    Ensembl:ENSG00000165553 MIM:605304; AllianceGenome:HGNC:14077
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in adrenal (RPKM 4.2), brain (RPKM 1.8) and 3 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See NGB in Genome Data Viewer
    Location:
    14q24.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (77265483..77271206, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (71474790..71480551, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (77731826..77737549, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8796 Neighboring gene transmembrane protein 63C Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:77666368-77666882 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8797 Neighboring gene uncharacterized LOC124903351 Neighboring gene microRNA 1260a Neighboring gene protein O-mannosyltransferase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5968 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:77769341-77769842 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:77769843-77770342 Neighboring gene Sharpr-MPRA regulatory region 2495 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5969 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5970 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:77787600-77788461 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:77795945-77797144 Neighboring gene glutathione S-transferase zeta 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GDP-dissociation inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nitrite reductase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables oxygen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables oxygen binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables oxygen carrier activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables oxygen carrier activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in oxygen transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in oxygen transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in response to hypoxia IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    neuroglobin
    Names
    nitrite reductase

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021257.4NP_067080.1  neuroglobin

      See identical proteins and their annotated locations for NP_067080.1

      Status: REVIEWED

      Source sequence(s)
      AC007375
      Consensus CDS
      CCDS9856.1
      UniProtKB/Swiss-Prot
      Q9NPG2
      UniProtKB/TrEMBL
      A0M8W9
      Related
      ENSP00000298352.4, ENST00000298352.5
      Conserved Domains (1) summary
      cd08920
      Location:1148
      Ngb; Neuroglobins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      77265483..77271206 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      71474790..71480551 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)