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    DUSP13B dual specificity phosphatase 13B [ Homo sapiens (human) ]

    Gene ID: 51207, updated on 3-Dec-2024

    Summary

    Official Symbol
    DUSP13Bprovided by HGNC
    Official Full Name
    dual specificity phosphatase 13Bprovided by HGNC
    Primary source
    HGNC:HGNC:19681
    See related
    Ensembl:ENSG00000079393 MIM:613191; AllianceGenome:HGNC:19681
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MDSP; TMDP; SKRP4; DUSP13
    Summary
    Members of the protein-tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This gene encodes a dual specificity phosphatase that acts on both phosphotyrosine and phosphoserine/threonine residues. The encoded protein is expressed in testis. [provided by RefSeq, Mar 2023]
    Expression
    Biased expression in testis (RPKM 6.3), heart (RPKM 1.5) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See DUSP13B in Genome Data Viewer
    Location:
    10q22.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (75094434..75109191, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (75967932..75982690, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (76854192..76868949, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3605 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3606 Neighboring gene dual specificity phosphatase 29 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:76817979-76818530 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:76829139-76829638 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:76836023-76836606 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:76839152-76839713 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:76839714-76840274 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:76842102-76842602 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:76844610-76845110 Neighboring gene peptidylprolyl isomerase A pseudogene 13 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:76863200-76864044 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:76864045-76864889 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:76865735-76866578 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:76870224-76871173 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:76871174-76872122 Neighboring gene sterile alpha motif domain containing 8 Neighboring gene dual specificity phosphatase 13A Neighboring gene uncharacterized LOC124902460 Neighboring gene ribosomal protein S26 pseudogene 42

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ32450

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables MAP kinase phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine/serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in meiotic cell cycle TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein dephosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermatogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    dual specificity protein phosphatase 13B
    Names
    Testis- and skeletal muscle-specific DUSP
    dual specificity phosphatase 13
    testis- and skeletal-muscle-specific DSP
    NP_001007273.1
    NP_001007274.1
    NP_001307771.1
    NP_001307772.1
    NP_001350443.1
    NP_001399156.1
    NP_057448.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033976.1 RefSeqGene

      Range
      14701..19777
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001007272.2NP_001007273.1  dual specificity protein phosphatase 13B isoform 2

      See identical proteins and their annotated locations for NP_001007273.1

      Status: REVIEWED

      Description
      Transcript Variant: TThis variant (2) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 9. The encoded isoform (2, also called TMDP-L2) has an alternate N-terminus, compared to isoform 9. Efforts to detect expression of isoform 2 were unsuccessful.
      Source sequence(s)
      AI971328, AK127886, AY674051
      Consensus CDS
      CCDS31224.1
      UniProtKB/TrEMBL
      U3KQA1
      Conserved Domains (1) summary
      cd00127
      Location:95238
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    2. NM_001007273.2NP_001007274.1  dual specificity protein phosphatase 13B isoform 3 precursor

      See identical proteins and their annotated locations for NP_001007274.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 9. The encoded isoform (3, also called TMDP-L1) has an alternate N-terminus, compared to isoform 9. Efforts to detect expression of isoform 3 were unsuccessful. Both variants 3 and 7 encode the same isoform (3).
      Source sequence(s)
      AI971328, AK127886, AY674051, BU580940
      UniProtKB/TrEMBL
      A0A9L9PXN7
      Related
      ENSP00000516748.1, ENST00000707120.1
      Conserved Domains (1) summary
      cd00127
      Location:138281
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    3. NM_001320842.2NP_001307771.1  dual specificity protein phosphatase 13B isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 9. The encoded isoform (3, also known as TMDP-L1) has an alternate N-terminus, compared to isoform 9. Both variants 3 and 7 encode the same isoform (3).
      Source sequence(s)
      AI971328, AK127886, AY674051
      UniProtKB/TrEMBL
      A0A9L9PXN7
      Conserved Domains (1) summary
      cd00127
      Location:138281
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    4. NM_001320843.2NP_001307772.1  dual specificity protein phosphatase 13B isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 9. The encoded isoform (6, also known as TMDP) has a shorter N-terminus, compared to isoform 9. Both variants 6 and 8 encode the same isoform (6).
      Source sequence(s)
      AI971328, AK057012, AY674051, DA898973
      Consensus CDS
      CCDS7346.1
      UniProtKB/Swiss-Prot
      A0A024QZR6, A8K776, A8K782, B3KPY1, B3KXT0, B4DUK0, Q5JSC6, Q6IAR0, Q96GC2, Q9UII6, U3KQ82
      UniProtKB/TrEMBL
      U3KQA1
      Related
      ENSP00000516749.1, ENST00000707121.1
      Conserved Domains (1) summary
      cd14577
      Location:28191
      DUSP13B; dual specificity protein phosphatase 13 isoform B
    5. NM_001363514.2NP_001350443.1  dual specificity protein phosphatase 13B isoform 9

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) represents the allele encoded by the GRCh38 reference genome and encodes isoform 9.
      Source sequence(s)
      AL392111
      Consensus CDS
      CCDS86105.1
      Related
      ENSP00000475626.1, ENST00000478873.7
      Conserved Domains (1) summary
      cd00127
      Location:181324
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    6. NM_001412227.1NP_001399156.1  dual specificity protein phosphatase 13B isoform 10

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) uses the same exon combination as variant 9 but represents the allele encoded by the T2T-CHM13v2.0 genome assembly. The encoded isoform (10) has a shorter N-terminus due to translation initiation at a downstream start codon, compared to isoform 9.
      Source sequence(s)
      CP068268
      UniProtKB/TrEMBL
      U3KQA1
    7. NM_016364.3NP_057448.3  dual specificity protein phosphatase 13B isoform 6

      See identical proteins and their annotated locations for NP_057448.3

      Status: REVIEWED

      Description
      Transcript Variant: TThis variant (6) uses a downstream in-frame start codon, compared to variant 9. The encoded isoform (6, also called TMDP) has a shorter N-terminus, compared to isoform 9. Both variants 6 and 8 encode the same isoform (6).
      Source sequence(s)
      AB027004
      Consensus CDS
      CCDS7346.1
      UniProtKB/Swiss-Prot
      A0A024QZR6, A8K776, A8K782, B3KPY1, B3KXT0, B4DUK0, Q5JSC6, Q6IAR0, Q96GC2, Q9UII6, U3KQ82
      UniProtKB/TrEMBL
      U3KQA1
      Related
      ENSP00000444580.1, ENST00000472493.6
      Conserved Domains (1) summary
      cd14577
      Location:28191
      DUSP13B; dual specificity protein phosphatase 13 isoform B

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      75094434..75109191 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      75967932..75982690 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001007274.1: Suppressed sequence

      Description
      NM_001007274.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    2. NM_001007275.1: Suppressed sequence

      Description
      NM_001007275.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.