PVRIG PVR related immunoglobulin domain containing [Homo sapiens (human)] - Gene

Summary

Official Symbol: PVRIGprovided by HGNC
Official Full Name: PVR related immunoglobulin domain containingprovided by HGNC
Primary source: HGNC:HGNC:32190
See related: Ensembl:ENSG00000213413 MIM:617012; AllianceGenome:HGNC:32190
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CD112R; C7orf15
Summary: Enables phosphatase binding activity and signaling receptor activity. Involved in negative regulation of T cell receptor signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in lymph node (RPKM 13.9), spleen (RPKM 12.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q22.1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (100219248..100221490)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (101459061..101461299)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (99816871..99819113)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural basis for the immune recognition and selectivity of the immune receptor PVRIG for ligand Nectin-2.
Title: Structural basis for the immune recognition and selectivity of the immune receptor PVRIG for ligand Nectin-2.
Nonredundant Upregulation of CD112R (PVRIG) and PD-1 on Cytotoxic T Lymphocytes Located in T Cell Nests of Colorectal Cancer.
Title: Nonredundant Upregulation of CD112R (PVRIG) and PD-1 on Cytotoxic T Lymphocytes Located in T Cell Nests of Colorectal Cancer.
COM902, a novel therapeutic antibody targeting TIGIT augments anti-tumor T cell function in combination with PVRIG or PD-1 pathway blockade.
Title: COM902, a novel therapeutic antibody targeting TIGIT augments anti-tumor T cell function in combination with PVRIG or PD-1 pathway blockade.
Hitting the complexity of the TIGIT-CD96-CD112R-CD226 axis for next-generation cancer immunotherapy.
Title: Hitting the complexity of the TIGIT-CD96-CD112R-CD226 axis for next-generation cancer immunotherapy.
PVRIG is a novel NK cell immune checkpoint receptor in acute myeloid leukemia.
Title: PVRIG is a novel natural killer cell immune checkpoint receptor in acute myeloid leukemia.
we demonstrate that PVRIG and PVRL2 are expressed in human cancers and the PVRIG-PVRL2 and TIGIT-PVR pathways are nonredundant inhibitory signaling pathways.
Title: PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8(+) T-cell Function.
Blockade of TIGIT or CD112R, separately or together, enhances trastuzumab-triggered antitumor response by human NK cells.
Title: Blockade of CD112R and TIGIT signaling sensitizes human natural killer cell functions.
Describe CD112R, a member of poliovirus receptor-like proteins, as a new coinhibitory receptor for T cells. CD112R is preferentially expressed on T cells and inhibits T cell receptor-mediated signals.
Title: Identification of CD112R as a novel checkpoint for human T cells.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH94384 (e-PCR)
- UniSTS:89510

NoName (e-PCR)
- UniSTS:483051

STAG3_3530 (e-PCR)
- UniSTS:462572

Clone Names

MGC2463, MGC104322, MGC138295, MGC138297

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of T cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of T cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transmembrane protein PVRIG

Names: CD112 receptor; nectin-2 receptor; poliovirus receptor related immunoglobulin domain containing; poliovirus receptor-related immunoglobulin domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001387134.1 → NP_001374063.1 transmembrane protein PVRIG isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC005071

Conserved Domains (2) summary

cd00096
Location:23 → 26

Ig; Ig strand A [structural motif]

cl11960
Location:23 → 125

Ig; Immunoglobulin domain
NM_001397246.1 → NP_001384175.1 transmembrane protein PVRIG isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC005071

Consensus CDS

CCDS94154.1

UniProtKB/TrEMBL

A0A8V8TN58

Related

ENSP00000514123.1, ENST00000699088.1

Conserved Domains (1) summary

PHA03247
Location:64 → 304

PHA03247; large tegument protein UL36; Provisional
NM_024070.3 → NP_076975.2 transmembrane protein PVRIG isoform 1

See identical proteins and their annotated locations for NP_076975.2

Status: VALIDATED

Source sequence(s)

AC005071, BC073861

Consensus CDS

CCDS5690.1

UniProtKB/Swiss-Prot

D6W5U9, Q6DKI7, Q9BVK3

Related

ENSP00000316675.2, ENST00000317271.3

Conserved Domains (2) summary

cl11960
Location:57 → 145

Ig; Immunoglobulin domain

cl26464
Location:84 → 324

Atrophin-1; Atrophin-1 family