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    OAZ3 ornithine decarboxylase antizyme 3 [ Homo sapiens (human) ]

    Gene ID: 51686, updated on 9-Dec-2024

    Summary

    Official Symbol
    OAZ3provided by HGNC
    Official Full Name
    ornithine decarboxylase antizyme 3provided by HGNC
    Primary source
    HGNC:HGNC:8097
    See related
    Ensembl:ENSG00000143450 MIM:605138; AllianceGenome:HGNC:8097
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AZ3; OAZ-t; TISP15
    Summary
    The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake; however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies showed that homozygous mutant male mice were infertile, and indicated the likely role of this antizyme in the formation of a rigid connection between the sperm head and tail during spermatogenesis. Alternatively spliced transcript variants encoding different isoforms, including one resulting from the use of non-AUG (CUG) translation initiation codon, have been found for this gene. [provided by RefSeq, Dec 2014]
    Expression
    Biased expression in testis (RPKM 63.7) and prostate (RPKM 6.3) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See OAZ3 in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (151762969..151771330)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (150886358..150894807)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151735445..151743806)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 662, pseudogene Neighboring gene ribosomal protein S11 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1724 Neighboring gene mitochondrial ribosomal protein L9 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:151741546-151742242 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:151742243-151742937 Neighboring gene tudor and KH domain containing Neighboring gene chloride nucleotide-sensitive channel 1A pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1326 Neighboring gene TDRKH antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ornithine decarboxylase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ornithine decarboxylase inhibitor activity IDA
    Inferred from Direct Assay
    more info
     
    enables ornithine decarboxylase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of polyamine transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in polyamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in spermatogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in viral translational frameshifting IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in blood microparticle HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ornithine decarboxylase antizyme 3
    Names
    ODC-Az 3
    antizyme 3
    testicular secretory protein Li 31

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134939.1NP_001128411.1  ornithine decarboxylase antizyme 3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon and initiates translation from an AUG start codon, compared to variant 1. The resulting isoform (2) is shorter with a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AF175296, BC073949
      Consensus CDS
      CCDS58028.1
      UniProtKB/TrEMBL
      A0A0G2JH29
      Related
      ENSP00000313922.5, ENST00000321531.10
      Conserved Domains (2) summary
      pfam02100
      Location:87178
      ODC_AZ; Ornithine decarboxylase antizyme
      cl19115
      Location:6794
      Cupredoxin; Cupredoxin superfamily
    2. NM_001301371.1NP_001288300.1  ornithine decarboxylase antizyme 3 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' terminal exon and initiates translation from an AUG start codon, compared to variant 1. The resulting isoform (3) is shorter with a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      BC073949, BI830988
      Consensus CDS
      CCDS76216.1
      UniProtKB/TrEMBL
      H0Y7Y4
      Related
      ENSP00000415904.2, ENST00000453029.2
      Conserved Domains (2) summary
      pfam02100
      Location:100191
      ODC_AZ; Ornithine decarboxylase antizyme
      cl19115
      Location:80107
      Cupredoxin; Cupredoxin superfamily
    3. NM_016178.2NP_057262.2  ornithine decarboxylase antizyme 3 isoform 1

      See identical proteins and their annotated locations for NP_057262.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) initiates translation from a non-AUG (CUG) start codon, and encodes the longest isoform (1).
      Source sequence(s)
      AF175296, BC073949
      Consensus CDS
      CCDS81378.1
      UniProtKB/Swiss-Prot
      E7EUE7, Q6GMR0, Q9UMX2
      UniProtKB/TrEMBL
      A8MW57
      Related
      ENSP00000383784.3, ENST00000400999.7
      Conserved Domains (2) summary
      pfam02100
      Location:132223
      ODC_AZ; Ornithine decarboxylase antizyme
      cl19115
      Location:112139
      Cupredoxin; Cupredoxin superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      151762969..151771330
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      150886358..150894807
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)