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    HFE homeostatic iron regulator [ Homo sapiens (human) ]

    Gene ID: 3077, updated on 3-Dec-2024

    Summary

    Official Symbol
    HFEprovided by HGNC
    Official Full Name
    homeostatic iron regulatorprovided by HGNC
    Primary source
    HGNC:HGNC:4886
    See related
    Ensembl:ENSG00000010704 MIM:613609; AllianceGenome:HGNC:4886
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HH; HFE1; HLA-H; MVCD7; TFQTL2
    Summary
    The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. [provided by RefSeq, May 2022]
    Expression
    Ubiquitous expression in thyroid (RPKM 5.0), gall bladder (RPKM 4.6) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See HFE in Genome Data Viewer
    Location:
    6p22.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (26087429..26098343)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (25955571..25966491)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (26087657..26098571)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24185 Neighboring gene H3 clustered histone 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:26053365-26053538 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:26053937-26054558 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:26055179-26055800 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24186 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24187 Neighboring gene H1.2 linker histone, cluster member Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17000 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:26066841-26067340 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:26075238-26075738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:26075739-26076239 Neighboring gene HFE antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24188 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:26103833-26104523 Neighboring gene H4 clustered histone 3 Neighboring gene H1.6 linker histone, cluster member

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Hemochromatosis type 1
    MedGen: C3469186 OMIM: 235200 GeneReviews: HFE-Related Hemochromatosis
    Compare labs

    EBI GWAS Catalog

    Description
    A genome-wide association study of red blood cell traits using the electronic medical record.
    EBI GWAS Catalog
    A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.
    EBI GWAS Catalog
    Association of HFE and TMPRSS6 genetic variants with iron and erythrocyte parameters is only in part dependent on serum hepcidin concentrations.
    EBI GWAS Catalog
    Biological, clinical and population relevance of 95 loci for blood lipids.
    EBI GWAS Catalog
    Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways.
    EBI GWAS Catalog
    Common variants in TMPRSS6 are associated with iron status and erythrocyte volume.
    EBI GWAS Catalog
    Discovery and refinement of loci associated with lipid levels.
    EBI GWAS Catalog
    Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.
    EBI GWAS Catalog
    Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
    EBI GWAS Catalog
    Genome-wide admixture and association study of serum iron, ferritin, transferrin saturation and total iron binding capacity in African Americans.
    EBI GWAS Catalog
    Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network.
    EBI GWAS Catalog
    Genome-wide association study identifies genetic loci associated with iron deficiency.
    EBI GWAS Catalog
    Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
    EBI GWAS Catalog
    Genome-wide association study identifies two loci strongly affecting transferrin glycosylation.
    EBI GWAS Catalog
    Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels.
    EBI GWAS Catalog
    Genome-wide association study of hematological and biochemical traits in a Japanese population.
    EBI GWAS Catalog
    GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children.
    EBI GWAS Catalog
    Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels.
    EBI GWAS Catalog
    Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.
    EBI GWAS Catalog
    Novel association to the proprotein convertase PCSK7 gene locus revealed by analysing soluble transferrin receptor (sTfR) levels.
    EBI GWAS Catalog
    Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis.
    EBI GWAS Catalog
    Sequence variants in three loci influence monocyte counts and erythrocyte volume.
    EBI GWAS Catalog
    Seventy-five genetic loci influencing the human red blood cell.
    EBI GWAS Catalog
    Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef Myristoylation of HIV-1 Nef at position 2 and the PxxP proline-rich motif of Nef at positions 62-65 are required for Nef-induced downregulation of HFE; amino acid residue Y282 in HFE is involved in the downregulation by Nef PubMed
    nef HIV-1 Nef downregulates the macrophage-expressed MHC 1b protein HFE by rerouting HFE to a perinuclear structure that overlaps the trans-Golgi network, causing a 90% reduction of surface HFE PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC103790, MGC:150812, dJ221C16.10.1, IMAGE:40125754

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables beta-2-microglobulin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables co-receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    NOT enables peptide antigen binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT enables peptide antigen binding IKR
    Inferred from Key Residues
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transferrin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transferrin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT involved_in antigen processing and presentation IC
    Inferred by Curator
    more info
    PubMed 
    NOT involved_in antigen processing and presentation of peptide antigen via MHC class I IKR
    Inferred from Key Residues
    more info
    PubMed 
    involved_in cellular response to iron ion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in hormone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular iron ion homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in iron ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in multicellular organismal-level iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of CD8-positive, alpha-beta T cell activation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of T cell cytokine production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of SMAD protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of ferrous iron binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of peptide hormone secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of receptor binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of receptor-mediated endocytosis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of signaling receptor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transferrin receptor binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in protein-containing complex assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of iron ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of iron ion transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of protein localization to cell surface IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to iron ion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to iron ion starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of HFE-transferrin receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT part_of MHC class I protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT part_of MHC class I protein complex IKR
    Inferred from Key Residues
    more info
    PubMed 
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basal part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    hereditary hemochromatosis protein
    Names
    MHC class I-like protein HFE
    hereditary hemochromatosis protein HLA-H
    high Fe

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008720.2 RefSeqGene

      Range
      5001..12961
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_748

    mRNA and Protein(s)

    1. NM_000410.4NP_000401.1  hereditary hemochromatosis protein isoform 1 precursor

      See identical proteins and their annotated locations for NP_000401.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform.
      Source sequence(s)
      U91328
      Consensus CDS
      CCDS4578.1
      UniProtKB/Swiss-Prot
      B2CKL0, O75929, O75930, O75931, Q17RT0, Q30201, Q96KU5, Q96KU6, Q96KU7, Q96KU8, Q9HC64, Q9HC68, Q9HC70, Q9HC83
      UniProtKB/TrEMBL
      B4DV50
      Related
      ENSP00000417404.1, ENST00000357618.10
      Conserved Domains (2) summary
      cd07698
      Location:206298
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      cl08246
      Location:27202
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    2. NM_001300749.3NP_001287678.1  hereditary hemochromatosis protein isoform 12 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) uses an alternate splice acceptor site at its 3'-terminal exon, compared to variant 1. This variant encodes isoform 12 which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      U91328
      Consensus CDS
      CCDS75412.1
      UniProtKB/TrEMBL
      B4DV50, F8W7W8
      Related
      ENSP00000311698.6, ENST00000309234.11
      Conserved Domains (2) summary
      cd07698
      Location:206298
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      cl08246
      Location:27202
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    3. NM_001384164.1NP_001371093.1  hereditary hemochromatosis protein isoform 13 precursor

      Status: REVIEWED

      Source sequence(s)
      U91328
      UniProtKB/TrEMBL
      B4DV50, H7C4K4
      Related
      ENSP00000417534.2, ENST00000485729.2
      Conserved Domains (2) summary
      cd21021
      Location:204297
      IgC1_MHC_Ib_HLA-H; Class Ib major histocompatibility complex (MHC) immunoglobulin domain of human leukocyte antigen H; member of the C1-set of Ig superfamily (IgSF) domains
      cl08246
      Location:27202
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    4. NM_001406751.1NP_001393680.1  hereditary hemochromatosis protein isoform 14 precursor

      Status: REVIEWED

      Source sequence(s)
      U91328
      UniProtKB/TrEMBL
      B4DV50, Q6B0J5
      Related
      ENSP00000419725.1, ENST00000470149.5
    5. NM_001406752.1NP_001393681.1  hereditary hemochromatosis protein isoform 15 precursor

      Status: REVIEWED

      Source sequence(s)
      U91328
      UniProtKB/TrEMBL
      Q86WL1
    6. NM_139003.3NP_620572.1  hereditary hemochromatosis protein isoform 3 precursor

      See identical proteins and their annotated locations for NP_620572.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an internal in-frame segment of the coding region, as compared to variant 1, resulting in a shorter protein (isoform 3).
      Source sequence(s)
      AF149804, AJ249335, U91328
      Consensus CDS
      CCDS47386.1
      UniProtKB/TrEMBL
      K0IIP4
      Related
      ENSP00000337819.8, ENST00000336625.12
      Conserved Domains (2) summary
      cd07698
      Location:110192
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      cl08246
      Location:27113
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    7. NM_139004.3NP_620573.1  hereditary hemochromatosis protein isoform 4 precursor

      See identical proteins and their annotated locations for NP_620573.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an internal in-frame segment of the coding region, compared to variant 1, resulting in a shorter protein (isoform 4).
      Source sequence(s)
      AJ249337, U91328
      Consensus CDS
      CCDS4579.1
      UniProtKB/TrEMBL
      K0IIP4
      Related
      ENSP00000313776.7, ENST00000317896.11
      Conserved Domains (2) summary
      cd07698
      Location:114206
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      cl08246
      Location:27113
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    8. NM_139006.3NP_620575.1  hereditary hemochromatosis protein isoform 6 precursor

      See identical proteins and their annotated locations for NP_620575.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an internal in-frame segment of the coding region, as compared to variant 1, resulting in a shorter protein (isoform 6).
      Source sequence(s)
      AF079407, U91328
      Consensus CDS
      CCDS54974.1
      UniProtKB/TrEMBL
      B4DV50
      Related
      ENSP00000420802.1, ENST00000461397.6
      Conserved Domains (2) summary
      cd07698
      Location:207284
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      cl08246
      Location:27202
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    9. NM_139007.3NP_620576.1  hereditary hemochromatosis protein isoform 7 precursor

      See identical proteins and their annotated locations for NP_620576.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks an internal in-frame segment of the coding region, as compared to variant 1, resulting in a shorter protein isoform (7).
      Source sequence(s)
      AJ249336, U91328
      Consensus CDS
      CCDS4580.1
      UniProtKB/TrEMBL
      Q86WL1
      Related
      ENSP00000259699.6, ENST00000349999.8
      Conserved Domains (2) summary
      cd07698
      Location:118210
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      cl08246
      Location:27114
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    10. NM_139008.3NP_620577.1  hereditary hemochromatosis protein isoform 8 precursor

      See identical proteins and their annotated locations for NP_620577.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks two internal in-frame segments of the coding region, as compared to variant 1, resulting in a shorter protein (isoform 8).
      Source sequence(s)
      AF079409, U91328
      Consensus CDS
      CCDS54975.1
      UniProtKB/TrEMBL
      Q86WL1
      Related
      ENSP00000420559.1, ENST00000488199.5
      Conserved Domains (2) summary
      cd07698
      Location:119196
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      cl08246
      Location:27114
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    11. NM_139009.3NP_620578.1  hereditary hemochromatosis protein isoform 9 precursor

      See identical proteins and their annotated locations for NP_620578.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) lacks an internal in-frame segment of the coding region through the use of an alternate splice acceptor site, as compared to variant 1, resulting in a shorter protein (isoform 9).
      Source sequence(s)
      AJ249335, U91328
      Consensus CDS
      CCDS47387.1
      UniProtKB/TrEMBL
      B4DV50
      Related
      ENSP00000380217.3, ENST00000397022.7
      Conserved Domains (2) summary
      cd07698
      Location:183275
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      cl08246
      Location:23179
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    12. NM_139010.3NP_620579.1  hereditary hemochromatosis protein isoform 10 precursor

      See identical proteins and their annotated locations for NP_620579.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) lacks an internal in-frame segment of the coding region, as compared to variant 1, resulting in a shorter protein (isoform 10).
      Source sequence(s)
      AJ250635, U91328
      Consensus CDS
      CCDS4581.1
      UniProtKB/Swiss-Prot
      Q30201
      Related
      ENSP00000312342.5, ENST00000353147.9
      Conserved Domains (1) summary
      cd07698
      Location:27118
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    13. NM_139011.3NP_620580.1  hereditary hemochromatosis protein isoform 11 precursor

      See identical proteins and their annotated locations for NP_620580.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) lacks a large internal part of the coding region but the reading frame is maintained, as compared to variant 1. The protein encoded is the shortest isoform (11).
      Source sequence(s)
      AJ249338, U91328
      Consensus CDS
      CCDS4582.1
      UniProtKB/Swiss-Prot
      Q30201
      Related
      ENSP00000315936.4, ENST00000352392.8

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      26087429..26098343
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_241893.5 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      25955571..25966491
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_008487320.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_139002.2: Suppressed sequence

      Description
      NM_139002.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    2. NM_139005.2: Suppressed sequence

      Description
      NM_139005.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.