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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_013351.1 RefSeqGene
- Range
-
5001..25374
- Download
- GenBank, FASTA, Sequence Viewer (Graphics), LRG_726
mRNA and Protein(s)
-
NM_001330358.2 → NP_001317287.1 methylenetetrahydrofolate reductase (NADPH) isoform 1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) encodes the longer isoform (1).
- Source sequence(s)
-
AL953897
- Consensus CDS
-
CCDS81262.1
- UniProtKB/TrEMBL
-
Q59GJ6
- Related
- ENSP00000365767.3, ENST00000376583.7
-
NM_001410750.1 → NP_001397679.1 methylenetetrahydrofolate reductase (NADPH) isoform 3
Status: REVIEWED
- Source sequence(s)
-
AL953897
- Consensus CDS
-
CCDS90864.1
- UniProtKB/TrEMBL
- Q59GJ6, Q5SNW7
- Related
- ENSP00000398908.3, ENST00000423400.7
-
NM_005957.5 → NP_005948.3 methylenetetrahydrofolate reductase (NADPH) isoform 2
See identical proteins and their annotated locations for NP_005948.3
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
- Source sequence(s)
-
AB209113, AJ237672, AL953897, AY046560, BC053509
- Consensus CDS
-
CCDS137.1
- UniProtKB/Swiss-Prot
- B2R7A6, P42898, Q5SNW6, Q5SNW9, Q7Z6M6, Q8IU73, Q9UQR2
- UniProtKB/TrEMBL
-
A0A286YF17
- Related
- ENSP00000365775.3, ENST00000376590.9
- Conserved Domains (1) summary
-
- cl00246
Location:60 → 626
- MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000001.11 Reference GRCh38.p14 Primary Assembly
- Range
-
11785723..11805964 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_047421181.1 → XP_047277137.1 methylenetetrahydrofolate reductase (NADPH) isoform X6
- UniProtKB/TrEMBL
-
A0A286YF17
-
XM_005263462.5 → XP_005263519.1 methylenetetrahydrofolate reductase (NADPH) isoform X3
See identical proteins and their annotated locations for XP_005263519.1
- UniProtKB/Swiss-Prot
- B2R7A6, P42898, Q5SNW6, Q5SNW9, Q7Z6M6, Q8IU73, Q9UQR2
- UniProtKB/TrEMBL
-
A0A286YF17
- Conserved Domains (1) summary
-
- cl00246
Location:60 → 626
- MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...
-
XM_047421179.1 → XP_047277135.1 methylenetetrahydrofolate reductase (NADPH) isoform X5
- UniProtKB/TrEMBL
- A0A286YFD0, Q59GJ6
- Related
- ENSP00000493098.1, ENST00000641407.1
-
XM_047421180.1 → XP_047277136.1 methylenetetrahydrofolate reductase (NADPH) isoform X6
- UniProtKB/TrEMBL
-
A0A286YF17
- Related
- ENSP00000493262.1, ENST00000641446.1
-
XM_047421178.1 → XP_047277134.1 methylenetetrahydrofolate reductase (NADPH) isoform X3
- UniProtKB/Swiss-Prot
- B2R7A6, P42898, Q5SNW6, Q5SNW9, Q7Z6M6, Q8IU73, Q9UQR2
- UniProtKB/TrEMBL
-
A0A286YF17
- Related
- ENSP00000365777.1, ENST00000376592.6
-
XM_047421174.1 → XP_047277130.1 methylenetetrahydrofolate reductase (NADPH) isoform X2
- UniProtKB/TrEMBL
-
Q59GJ6
-
XM_011541496.4 → XP_011539798.1 methylenetetrahydrofolate reductase (NADPH) isoform X1
- UniProtKB/TrEMBL
-
Q59GJ6
- Conserved Domains (1) summary
-
- cl00246
Location:101 → 625
- MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...
-
XM_017001328.3 → XP_016856817.1 methylenetetrahydrofolate reductase (NADPH) isoform X4
- UniProtKB/TrEMBL
-
A0A286YF17
-
XM_005263463.5 → XP_005263520.1 methylenetetrahydrofolate reductase (NADPH) isoform X7
- UniProtKB/TrEMBL
-
A0A286YF17
- Conserved Domains (1) summary
-
- cl00246
Location:1 → 544
- MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...
Alternate T2T-CHM13v2.0
Genomic
-
NC_060925.1 Alternate T2T-CHM13v2.0
- Range
-
11329802..11350048 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054336702.1 → XP_054192677.1 methylenetetrahydrofolate reductase (NADPH) isoform X3
- UniProtKB/TrEMBL
-
A0A286YF17
-
XM_054336707.1 → XP_054192682.1 methylenetetrahydrofolate reductase (NADPH) isoform X7
- UniProtKB/TrEMBL
-
A0A286YF17
-
XM_054336706.1 → XP_054192681.1 methylenetetrahydrofolate reductase (NADPH) isoform X6
- UniProtKB/TrEMBL
-
A0A286YF17
-
XM_054336704.1 → XP_054192679.1 methylenetetrahydrofolate reductase (NADPH) isoform X5
- UniProtKB/TrEMBL
-
Q59GJ6
-
XM_054336705.1 → XP_054192680.1 methylenetetrahydrofolate reductase (NADPH) isoform X6
- UniProtKB/TrEMBL
-
A0A286YF17
-
XM_054336701.1 → XP_054192676.1 methylenetetrahydrofolate reductase (NADPH) isoform X2
- UniProtKB/TrEMBL
-
Q59GJ6
-
XM_054336700.1 → XP_054192675.1 methylenetetrahydrofolate reductase (NADPH) isoform X1
- UniProtKB/TrEMBL
-
Q59GJ6
-
XM_054336703.1 → XP_054192678.1 methylenetetrahydrofolate reductase (NADPH) isoform X4
- UniProtKB/TrEMBL
-
A0A286YF17