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    PART1 prostate androgen-regulated transcript 1 [ Homo sapiens (human) ]

    Gene ID: 25859, updated on 24-Sep-2024

    Summary

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    Official Symbol
    PART1provided by HGNC
    Official Full Name
    prostate androgen-regulated transcript 1provided by HGNC
    Primary source
    HGNC:HGNC:17263
    See related
    Ensembl:ENSG00000152931 MIM:604991; AllianceGenome:HGNC:17263
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NCRNA00206
    Summary
    This gene is induced by androgen in prostate adenocarcinoma cells. Multiple alternatively transcript variants have been described for this gene, none of which are predicted to encode a protein product. [provided by RefSeq, Sep 2009]
    Expression
    Biased expression in brain (RPKM 4.1), prostate (RPKM 3.9) and 5 other tissues See more
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    Genomic context

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    See PART1 in Genome Data Viewer
    Location:
    5q12.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (60487713..60547657)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (61306025..61365980)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (59783540..59843484)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 4D Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22586 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22587 Neighboring gene Sharpr-MPRA regulatory region 9229 Neighboring gene ribosomal protein L31 pseudogene 8 Neighboring gene SET pseudogene 21 Neighboring gene Sharpr-MPRA regulatory region 1909 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16038 Neighboring gene uncharacterized LOC124900982 Neighboring gene DEP domain containing 1B Neighboring gene calcium binding protein 39 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The Role of Tumor-related LncRNA PART1 in Cancer. Chen J, et al. Curr Pharm Des, 2021. PMID 34225608
    2. LncRNA PART1 facilitates the malignant progression of colorectal cancer via miR-150-5p/LRG1 axis. Lou T, et al. J Cell Biochem, 2020 Oct. PMID 31898365
    3. LncRNA PART1 modulates chondrocyte proliferation, apoptosis, and extracellular matrix degradation in osteoarthritis via regulating miR-373-3p/SOX4 axis. Zhu YJ, et al. Eur Rev Med Pharmacol Sci, 2019 Oct. PMID 31646607
    4. Silencing of lncRNA PART1 inhibits proliferation, invasion and migration of breast cancer cells and promotes the efficacy of cisplatin in breast cancer cells. Zhang L, et al. Gen Physiol Biophys, 2020 Jul. PMID 32700682
    5. LncRNA PART1 promotes cell proliferation and inhibits apoptosis of oral squamous cell carcinoma by blocking EZH2 degradation. Yu Q, et al. J Biochem, 2021 Sep 7. PMID 33725092

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Blockade of the lncRNA-PART1-PHB2 axis confers resistance to PARP inhibitor and promotes cellular senescence in ovarian cancer.
      Title: Blockade of the lncRNA-PART1-PHB2 axis confers resistance to PARP inhibitor and promotes cellular senescence in ovarian cancer.
    2. Friend leukemia integration 1 overexpression decreases endometrial receptivity and induces embryo implantation failure by promoting PART1 transcription in the endometrial epithelial cells.
      Title: Friend leukemia integration 1 overexpression decreases endometrial receptivity and induces embryo implantation failure by promoting PART1 transcription in the endometrial epithelial cells.
    3. LncRNA PART1 Regulates Ovarian Carcinoma Development via the miR-150-5p/MYB Axis.
      Title: LncRNA PART1 Regulates Ovarian Carcinoma Development via the miR-150-5p/MYB Axis.
    4. Exosome-mediated long noncoding RNA (lncRNA) PART1 suppresses malignant progression of oral squamous cell carcinoma via miR-17-5p/SOCS6 axis.
      Title: Exosome-mediated long noncoding RNA (lncRNA) PART1 suppresses malignant progression of oral squamous cell carcinoma via miR-17-5p/SOCS6 axis.
    5. Associations of PART1 and DEFB1 polymorphisms with Dental Caries in twelve-year-old children in Southern China: a cross-sectional study.
      Title: Associations of PART1 and DEFB1 polymorphisms with Dental Caries in twelve-year-old children in Southern China: a cross-sectional study.
    6. Long noncoding RNA PART1: dual role in cancer.
      Title: Long non‑coding RNA PART1: dual role in cancer.
    7. LncRNA PART1 Stimulates the Development of Ovarian Cancer by Up-regulating RACGAP1 and RRM2.
      Title: LncRNA PART1 Stimulates the Development of Ovarian Cancer by Up-regulating RACGAP1 and RRM2.
    8. LncRNA PART1/miR-185-5p/RUNX3 feedback loop modulates osteogenic differentiation of bone marrow mesenchymal stem cells.
      Title: LncRNA PART1/miR-185-5p/RUNX3 feedback loop modulates osteogenic differentiation of bone marrow mesenchymal stem cells.
    9. The Role of Tumor-related LncRNA PART1 in Cancer.
      Title: The Role of Tumor-related LncRNA PART1 in Cancer.
    10. PART1 destabilized by NOVA2 regulates blood-brain barrier permeability in endothelial cells via STAU1-mediated mRNA degradation.
      Title: PART1 destabilized by NOVA2 regulates blood-brain barrier permeability in endothelial cells via STAU1-mediated mRNA degradation.
    Submit: New GeneRIF Correction See all GeneRIFs (25)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Other Names

    • prostate androgen-regulated transcript 1 (non-protein coding)
    • prostate-specific and androgen-regulated cDNA 14D7 protein

    Clone Names

    • DKFZp586D0823

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_024617.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) contains different segments for its 3' end, compared to variant 3.
      Source sequence(s)
      AK094518, AK312071, BC069304

    2. NR_028508.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a different segment for its 3' end, compared to variant 3.
      Source sequence(s)
      AF163475, BQ898163
      Related
      ENST00000515734.2

    3. NR_028509.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript.
      Source sequence(s)
      AC016591, AF070547, AF163475
      Related
      ENST00000661844.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      60487713..60547657
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      61306025..61365980
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001039499.1: Suppressed sequence

      Description
      NM_001039499.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    2. NM_001040639.1: Suppressed sequence

      Description
      NM_001040639.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version

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