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    mutS DNA mismatch repair protein MutS [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 880229, updated on 24-Aug-2024

    Summary

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    Gene symbol
    mutS
    Gene description
    DNA mismatch repair protein MutS
    Locus tag
    PA3620
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (4054525..4057092)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene ferredoxin I Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of MutS oligomers on Pseudomonas aeruginosa mismatch repair system activity. Miguel V, et al. DNA Repair (Amst), 2008 Nov 1. PMID 18687413
    2. Inactivation of the mismatch repair system in Pseudomonas aeruginosa attenuates virulence but favors persistence of oropharyngeal colonization in cystic fibrosis mice. Mena A, et al. J Bacteriol, 2007 May. PMID 17307847, Free PMC Article
    3. MutS regulates access of the error-prone DNA polymerase Pol IV to replication sites: a novel mechanism for maintaining replication fidelity. Margara LM, et al. Nucleic Acids Res, 2016 Sep 19. PMID 27257069, Free PMC Article
    4. Functional analysis of the interaction between the mismatch repair protein MutS and the replication processivity factor β clamp in Pseudomonas aeruginosa. Monti MR, et al. DNA Repair (Amst), 2012 May 1. PMID 22365420
    5. Altering the conserved nucleotide binding motif in the Salmonella typhimurium MutS mismatch repair protein affects both its ATPase and mismatch binding activities. Haber LT, et al. EMBO J, 1991 Sep. PMID 1651234, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the MutS-beta clamp association is critical for controlling Pol IV mutagenic replication under normal growth conditions.
      Title: MutS regulates access of the error-prone DNA polymerase Pol IV to replication sites: a novel mechanism for maintaining replication fidelity.
    2. the MutS-beta clamp interaction does not have a central role in the methylation-independent Mismatch Repair of P. aeruginosa.
      Title: Functional analysis of the interaction between the mismatch repair protein MutS and the replication processivity factor β clamp in Pseudomonas aeruginosa.
    3. although dimeric MutS is sufficient for MMR activity, optimal activity is obtained with the tetrameric version of the protein and therefore it should be considered as the active form of MutS in P. aeruginosa
      Title: The role of MutS oligomers on Pseudomonas aeruginosa mismatch repair system activity.
    4. inactivation of the mismatch repair (MMR) system of Pseudomonas aeruginosa modestly reduced in vitro fitness, attenuated virulence in murine models of acute systemic and respiratory infections.
      Title: Inactivation of the mismatch repair system in Pseudomonas aeruginosa attenuates virulence but favors persistence of oropharyngeal colonization in cystic fibrosis mice.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA mismatch repair protein MutS
    NP_252310.1
    • Product name confidence: class 2 (High similarity to functionally studied protein)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      4054525..4057092
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_252310.1 DNA mismatch repair protein MutS [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_252310.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2R3IQI2
      Conserved Domains (1) summary
      PRK05399
      Location:1 → 852
      PRK05399; DNA mismatch repair protein MutS; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HY08.1

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