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    Fkbpl FK506 binding protein-like [ Mus musculus (house mouse) ]

    Gene ID: 56299, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fkbplprovided by MGI
    Official Full Name
    FK506 binding protein-likeprovided by MGI
    Primary source
    MGI:MGI:1932127
    See related
    Ensembl:ENSMUSG00000033739 AllianceGenome:MGI:1932127
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NG7; DIR1; Wisp39; Ppiase-X
    Summary
    Acts upstream of or within regulation of blood vessel branching. Predicted to be located in extracellular region. Is expressed in several structures, including eye; gut; hemolymphoid system; male reproductive gland or organ; and nervous system. Orthologous to human FKBPL (FKBP prolyl isomerase like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 17.6), colon adult (RPKM 3.5) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fkbpl in Genome Data Viewer
    Location:
    17 B1; 17 18.22 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34863788..34865791)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34644814..34646817)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2610029K11 gene Neighboring gene palmitoyl-protein thioesterase 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:34767227-34767451 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:34768061-34768244 Neighboring gene proline-rich transmembrane protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E770 Neighboring gene STARR-positive B cell enhancer ABC_E4212 Neighboring gene activating transcription factor 6 beta Neighboring gene tenascin XB Neighboring gene predicted gene, 24389

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. FKBPL is a critical antiangiogenic regulator of developmental and pathological angiogenesis. Yakkundi A, et al. Arterioscler Thromb Vasc Biol, 2015 Apr. PMID 25767277, Free PMC Article
    2. Regulation of p21(WAF1/CIP1) stability by WISp39, a Hsp90 binding TPR protein. Jascur T, et al. Mol Cell, 2005 Jan 21. PMID 15664193
    3. The human and mouse MHC class III region: a parade of 21 genes at the centromeric segment. Yung Yu C, et al. Immunol Today, 2000 Jul. PMID 10871871
    4. FK506-binding protein-like and FK506-binding protein 8 regulate dual leucine zipper kinase degradation and neuronal responses to axon injury. Lee B, et al. J Biol Chem, 2022 Mar. PMID 35101451, Free PMC Article
    5. The mouse as a model for the effects of MHC genes on human disease. Allcock RJ, et al. Immunol Today, 2000 Jul. PMID 10871872

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FKBPL is an important regulator of developmental and pathological angiogenesis.
      Title: FKBPL is a critical antiangiogenic regulator of developmental and pathological angiogenesis.
    2. Results demonstrate the importance of posttranslational stabilization of p21 protein by WISp39 in regulating cellular p21 activity.
      Title: Regulation of p21(WAF1/CIP1) stability by WISp39, a Hsp90 binding TPR protein.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of blood vessel branching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vasculature development ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    FK506-binding protein-like
    Names
    WAF-1/CIP1 stabilizing protein 39
    immunophilin-like protein NG7
    NP_063926.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019873.3 → NP_063926.1  FK506-binding protein-like

      See identical proteins and their annotated locations for NP_063926.1

      Status: VALIDATED

      Source sequence(s)
      AK146018, CD776267, CT009767
      Consensus CDS
      CCDS28654.1
      UniProtKB/Swiss-Prot
      O35450, Q3UKG5
      Related
      ENSMUSP00000037273.9, ENSMUST00000036720.9
      Conserved Domains (3) summary
      COG0457
      Location:203 → 316
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:208 → 236
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:285 → 317
      TPR_1; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      34863788..34865791
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35450.1 GenPept UniProtKB/Swiss-Prot:O35450

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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