Kpna3 karyopherin subunit alpha 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kpna3provided by MGI
Official Full Name: karyopherin subunit alpha 3provided by MGI
Primary source: MGI:MGI:1100863
See related: Ensembl:ENSMUSG00000021929 AllianceGenome:MGI:1100863
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IPOA4
Summary: Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to be part of NLS-dependent protein nuclear import complex. Predicted to be active in nucleoplasm. Is expressed in several structures, including gonad; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 88. Orthologous to human KPNA3 (karyopherin subunit alpha 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 19.9), CNS E18 (RPKM 18.5) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D1; 14 32.76 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (61602635..61677396, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (61365186..61439947, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In postnatal testes, importin alpha3 and alpha4 in spermatocytes, spermatids, and Sertoli cells display cytoplasmic and nuclear localization, respectively.
Title: Subcellular distribution of importins correlates with germ cell maturation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G43604 (e-PCR)
- UniSTS:95039

D13S663E (e-PCR)
- UniSTS:153194

NoName (e-PCR)
- UniSTS:237203

KPNA3_1525 (e-PCR)
- UniSTS:462306

KPNA3_v515 (e-PCR)
- UniSTS:462306

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables nuclear import signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear import signal receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear localization sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in NLS-bearing protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into nucleus	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of NLS-dependent protein nuclear import complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	NAS Non-traceable Author Statement more info	PubMed
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	NAS Non-traceable Author Statement more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: importin subunit alpha-4

Names: importin alpha 4; importin alpha Q2; importin subunit alpha-3; karyopherin (importin) alpha 3; qip2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008466.5 → NP_032492.1 importin subunit alpha-4

See identical proteins and their annotated locations for NP_032492.1

Status: VALIDATED

Source sequence(s)

AC154435, AK049373, AV581906

Consensus CDS

CCDS36942.1

UniProtKB/Swiss-Prot

O35344

UniProtKB/TrEMBL

Q543M7

Related

ENSMUSP00000022496.8, ENSMUST00000022496.9

Conserved Domains (2) summary

COG5064
Location:7 → 521

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00043
Location:244 → 269

ARM; armadillo repeat [structural motif]