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    Fam168b family with sequence similarity 168, member B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 690188, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Fam168bprovided by RGD
    Official Full Name
    family with sequence similarity 168, member Bprovided by RGD
    Primary source
    RGD:1583985
    See related
    EnsemblRapid:ENSRNOG00000023467 AllianceGenome:RGD:1583985
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to act upstream of or within axonogenesis and gene expression. Predicted to be located in axon; perinuclear region of cytoplasm; and plasma membrane. Predicted to be active in membrane. Orthologous to human FAM168B (family with sequence similarity 168 member B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 192.3), Thymus (RPKM 182.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fam168b in Genome Data Viewer
    Location:
    9q21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (44501466..44534571, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (37005569..37038631, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (41305570..41337536, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 4 Neighboring gene uncharacterized LOC120094663 Neighboring gene small integral membrane protein 39 Neighboring gene uncharacterized LOC120094662 Neighboring gene pleckstrin homology domain containing B2 Neighboring gene U1 spliceosomal RNA Neighboring gene ribosomal protein S14, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterizing the neurite outgrowth inhibitory effect of Mani. Mishra M, et al. FEBS Lett, 2012 Sep 21. PMID 22771904
    2. The novel protein MANI modulates neurogenesis and neurite-cone growth. Mishra M, et al. J Cell Mol Med, 2011 Aug. PMID 20716133, Free PMC Article
    3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within axonogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neurogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    myelin-associated neurite-outgrowth inhibitor
    Names
    mani
    protein FAM168B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271134.1 → NP_001258063.1  myelin-associated neurite-outgrowth inhibitor

      See identical proteins and their annotated locations for NP_001258063.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      D4AEP3
      Related
      ENSRNOP00000112438.1, ENSRNOT00000127370.1
      Conserved Domains (1) summary
      pfam14944
      Location:1 → 194
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      44501466..44534571 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017596648.3 → XP_017452137.1  myelin-associated neurite-outgrowth inhibitor isoform X3

      UniProtKB/TrEMBL
      A0A8L2QHF9
      Conserved Domains (1) summary
      pfam14944
      Location:1 → 201
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

    2. XM_008766978.4 → XP_008765200.1  myelin-associated neurite-outgrowth inhibitor isoform X1

      See identical proteins and their annotated locations for XP_008765200.1

      UniProtKB/TrEMBL
      A0A8L2QHF9
      Related
      ENSRNOP00000033168.7, ENSRNOT00000039480.7
      Conserved Domains (1) summary
      pfam14944
      Location:1 → 213
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

    3. XM_017596649.3 → XP_017452138.1  myelin-associated neurite-outgrowth inhibitor isoform X4

      Conserved Domains (1) summary
      pfam14944
      Location:1 → 174
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

    4. XM_008766975.4 → XP_008765197.2  myelin-associated neurite-outgrowth inhibitor isoform X2

      UniProtKB/TrEMBL
      A0A8L2QHF9
      Conserved Domains (1) summary
      pfam14944
      Location:1 → 206
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

    5. XM_063267764.1 → XP_063123834.1  myelin-associated neurite-outgrowth inhibitor isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D4AEP3.1 GenPept UniProtKB/Swiss-Prot:D4AEP3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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