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    Ftsj1 FtsJ RNA 2'-O-methyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363450, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ftsj1provided by RGD
    Official Full Name
    FtsJ RNA 2'-O-methyltransferase 1provided by RGD
    Primary source
    RGD:1561061
    See related
    EnsemblRapid:ENSRNOG00000004776 AllianceGenome:RGD:1561061
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561061
    Summary
    Predicted to enable S-adenosyl-L-methionine binding activity; tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase activity; and tRNA 2'-O-methyltransferase activity. Predicted to be involved in cytoplasmic translation; neurogenesis; and wobble position ribose methylation. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 9. Orthologous to human FTSJ1 (FtsJ RNA 2'-O-methyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 29.9), Spleen (RPKM 26.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ftsj1 in Genome Data Viewer
    Location:
    Xq12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (16915087..16929426)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (14243684..14256555)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (14993685..15006010)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 38, member 5 Neighboring gene ribosomal protein L29, pseudogene 21 Neighboring gene uncharacterized LOC134484175 Neighboring gene porcupine O-acyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Defects in tRNA Anticodon Loop 2'-O-Methylation Are Implicated in Nonsyndromic X-Linked Intellectual Disability due to Mutations in FTSJ1. Guy MP, et al. Hum Mutat, 2015 Dec. PMID 26310293, Free PMC Article
    2. Conservation of an intricate circuit for crucial modifications of the tRNAPhe anticodon loop in eukaryotes. Guy MP, et al. RNA, 2015 Jan. PMID 25404562, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables S-adenosyl-L-methionine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA (guanine) methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA 2'-O-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neurogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA nucleoside ribose methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in wobble position ribose methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase
    Names
    FtsJ RNA methyltransferase homolog 1
    Ftsj homolog 1
    putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase
    NP_001388094.1
    NP_001388095.1
    XP_006256811.1
    XP_006256812.1
    XP_008771308.1
    XP_008771309.1
    XP_008771310.1
    XP_008771313.1
    XP_038956390.1
    XP_038956393.1
    XP_038956394.1
    XP_038956395.1
    XP_063136187.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401165.1 → NP_001388094.1  tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I6A982

    2. NM_001401166.1 → NP_001388095.1  tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I6A982
      Related
      ENSRNOP00000088344.1, ENSRNOT00000100380.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      16915087..16929426
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008773086.4 → XP_008771308.1  tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase isoform X1

      See identical proteins and their annotated locations for XP_008771308.1

      UniProtKB/TrEMBL
      A0A8I6A982, D3ZZA1
      Related
      ENSRNOP00000006365.7, ENSRNOT00000006365.8
      Conserved Domains (1) summary
      COG0293
      Location:4 → 203
      RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]

    2. XM_008773088.4 → XP_008771310.1  tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase isoform X1

      See identical proteins and their annotated locations for XP_008771310.1

      UniProtKB/TrEMBL
      A0A8I6A982, D3ZZA1
      Conserved Domains (1) summary
      COG0293
      Location:4 → 203
      RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]

    3. XM_063280117.1 → XP_063136187.1  tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase isoform X2

      UniProtKB/TrEMBL
      A0A8I6A982

    4. XM_008773091.4 → XP_008771313.1  tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase isoform X3

      See identical proteins and their annotated locations for XP_008771313.1

      UniProtKB/TrEMBL
      A0A8I6A982
      Conserved Domains (1) summary
      COG0293
      Location:4 → 203
      RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]

    5. XM_006256750.5 → XP_006256812.1  tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006256812.1

      UniProtKB/TrEMBL
      A0A8I6A982, D3ZZA1
      Conserved Domains (1) summary
      COG0293
      Location:4 → 203
      RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]

    6. XM_006256749.5 → XP_006256811.1  tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006256811.1

      UniProtKB/TrEMBL
      A0A8I6A982, D3ZZA1
      Related
      ENSRNOP00000110433.1, ENSRNOT00000162482.1
      Conserved Domains (1) summary
      COG0293
      Location:4 → 203
      RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]

    7. XM_008773087.4 → XP_008771309.1  tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase isoform X1

      See identical proteins and their annotated locations for XP_008771309.1

      UniProtKB/TrEMBL
      A0A8I6A982, D3ZZA1
      Conserved Domains (1) summary
      COG0293
      Location:4 → 203
      RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]

    8. XM_039100465.2 → XP_038956393.1  tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase isoform X4

      UniProtKB/TrEMBL
      A0A8I6A982
      Conserved Domains (1) summary
      COG0293
      Location:4 → 203
      RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]

    9. XM_039100462.2 → XP_038956390.1  tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8I6A982, D3ZZA1
      Conserved Domains (1) summary
      COG0293
      Location:4 → 203
      RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]

    10. XM_039100466.2 → XP_038956394.1  tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase isoform X5

      Conserved Domains (1) summary
      COG0293
      Location:1 → 125
      RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]

    11. XM_039100467.2 → XP_038956395.1  tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase isoform X6

      UniProtKB/TrEMBL
      A6KP37
      Conserved Domains (1) summary
      pfam01728
      Location:7 → 88
      FtsJ; FtsJ-like methyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version

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