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    Fpgs folylpolyglutamate synthase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 687266, updated on 27-Dec-2024

    Summary

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    Symbol
    Fpgsprovided by RGD
    Full Name
    folylpolyglutamate synthaseprovided by RGD
    Primary source
    RGD:1587713
    See related
    EnsemblRapid:ENSRNOG00000050780 AllianceGenome:RGD:1587713
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables tetrahydrofolylpolyglutamate synthase activity. Involved in animal organ regeneration and liver development. Predicted to be located in mitochondrial inner membrane. Predicted to be active in cytosol and mitochondrial matrix. Orthologous to human FPGS (folylpolyglutamate synthase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 144.6), Kidney (RPKM 75.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fpgs in Genome Data Viewer
    Location:
    3p11
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (36370505..36391314, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (15972800..15993592, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (11717667..11729694, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene adenylate kinase 1 Neighboring gene endoglin Neighboring gene cyclin-dependent kinase 9 Neighboring gene SH2 domain containing 3C Neighboring gene RNA, U6 small nuclear 899

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Glutamyl hydrolase. pharmacological role and enzymatic characterization. Galivan J, et al. Pharmacol Ther, 2000 Mar. PMID 10739875
    2. Enzymatic synthesis of folylpolyglutamates. Characterization of the reaction and its products. McGuire JJ, et al. J Biol Chem, 1980 Jun 25. PMID 6892914
    3. In vitro methotrexate polyglutamate synthesis by rat liver folylpolyglutamate synthetase and inhibition by bromosulfophthalein. McGuire JJ, et al. Adv Exp Med Biol, 1983. PMID 6193685
    4. Folylpolyglutamate synthetase activity in regenerating rat liver. Tolomelli B, et al. Int J Vitam Nutr Res, 1987. PMID 3654111
    5. Activation of mammalian folylpolyglutamate synthetase by sodium bicarbonate. Bolanowska WE, et al. Arch Biochem Biophys, 1990 Sep. PMID 2168155

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tetrahydrofolylpolyglutamate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tetrahydrofolylpolyglutamate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tetrahydrofolylpolyglutamate synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ regeneration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in folic acid-containing compound metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glutamate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in liver development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in nucleoside metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tetrahydrofolylpolyglutamate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tetrahydrofolylpolyglutamate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tetrahydrofolylpolyglutamate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    folylpolyglutamate synthase, mitochondrial
    NP_001139597.2
    XP_038961794.1
    XP_063140632.1
    XP_063140633.1
    XP_063140634.1
    XP_063140635.1
    XP_063140636.1
    XP_063140637.1
    XP_063140638.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146125.2 → NP_001139597.2  folylpolyglutamate synthase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001139597.2

      Status: PROVISIONAL

      Source sequence(s)
      CH474001
      UniProtKB/TrEMBL
      A6JU77, M0R401
      Related
      ENSRNOP00000064076.4, ENSRNOT00000070916.4
      Conserved Domains (1) summary
      PLN02881
      Location:42 → 581
      PLN02881; tetrahydrofolylpolyglutamate synthase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      36370505..36391314 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284563.1 → XP_063140633.1  folylpolyglutamate synthase, mitochondrial isoform X3

    2. XM_063284566.1 → XP_063140636.1  folylpolyglutamate synthase, mitochondrial isoform X6

      UniProtKB/TrEMBL
      A0A8I6AA44
      Related
      ENSRNOP00000088525.1, ENSRNOT00000106975.2

    3. XM_063284564.1 → XP_063140634.1  folylpolyglutamate synthase, mitochondrial isoform X4

    4. XM_063284567.1 → XP_063140637.1  folylpolyglutamate synthase, mitochondrial isoform X7

      Related
      ENSRNOP00000108396.1, ENSRNOT00000154787.1

    5. XM_063284562.1 → XP_063140632.1  folylpolyglutamate synthase, mitochondrial isoform X1

    6. XM_039105866.2 → XP_038961794.1  folylpolyglutamate synthase, mitochondrial isoform X2

      Related
      ENSRNOP00000108804.1, ENSRNOT00000139275.1
      Conserved Domains (1) summary
      PLN02881
      Location:42 → 670
      PLN02881; tetrahydrofolylpolyglutamate synthase

    7. XM_063284565.1 → XP_063140635.1  folylpolyglutamate synthase, mitochondrial isoform X5

    8. XM_063284568.1 → XP_063140638.1  folylpolyglutamate synthase, mitochondrial isoform X8

      UniProtKB/TrEMBL
      A6JU78
    Nucleotide Protein Strain
    Heading Accession and Version

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