Ckap5 cytoskeleton associated protein 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ckap5provided by RGD
Official Full Name: cytoskeleton associated protein 5provided by RGD
Primary source: RGD:1563596
See related: EnsemblRapid:ENSRNOG00000016067 AllianceGenome:RGD:1563596
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable microtubule binding activity; microtubule plus end polymerase; and ribonucleoprotein complex binding activity. Predicted to be involved in microtubule cytoskeleton organization and positive regulation of microtubule nucleation. Predicted to act upstream of or within several processes, including central nervous system myelin formation; dendritic spine maintenance; and learning. Predicted to be located in several cellular components, including neuronal ribonucleoprotein granule; nucleolus; and perikaryon. Predicted to be part of protein-containing complex. Predicted to be active in centrosome; kinetochore; and spindle pole. Predicted to colocalize with microtubule plus-end. Orthologous to human CKAP5 (cytoskeleton associated protein 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 287.1), Thymus (RPKM 264.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q24

Exon count:: 49

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (97946966..98049050)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (77491195..77593300)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (80424320..80526583)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CKAP5 is necessary for efficient translation of MBP mRNA and suggest that this role is mediated by its interaction with hnRNP A2.
Title: The microtubule-associated protein tumor overexpressed gene/cytoskeleton-associated protein 5 is necessary for myelin basic protein expression in oligodendrocytes.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule plus end polymerase	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule plus end polymerase	IEA Inferred from Electronic Annotation more info
enables microtubule plus-end binding	IEA Inferred from Electronic Annotation more info
enables ribonucleoprotein complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within central nervous system myelin formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within centrosome cycle	ISO Inferred from Sequence Orthology more info
involved_in centrosome cycle	ISO Inferred from Sequence Orthology more info
involved_in centrosome duplication	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of cytoplasmic translation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cytoplasmic translation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dendritic spine maintenance	ISO Inferred from Sequence Orthology more info
involved_in establishment or maintenance of microtubule cytoskeleton polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of microtubule cytoskeleton polarity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within habituation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mRNA localization resulting in post-transcriptional regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in microtubule polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule polymerization	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of microtubule nucleation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein-RNA complex assembly	ISO Inferred from Sequence Orthology more info
involved_in spindle organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within visual learning	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
colocalizes_with microtubule plus-end	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule plus-end	ISO Inferred from Sequence Orthology more info
located_in neuronal ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytoskeleton-associated protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001426928.1 → NP_001413857.1 cytoskeleton-associated protein 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A6HNC8, F1M949

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

97946966..98049050

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017592175.3 → XP_017447664.2 cytoskeleton-associated protein 5 isoform X1

UniProtKB/TrEMBL

A0A8I6ALB1, A6HNC8
XM_063283664.1 → XP_063139734.1 cytoskeleton-associated protein 5 isoform X1

UniProtKB/TrEMBL

A0A8I6ALB1, A6HNC8
XM_063283662.1 → XP_063139732.1 cytoskeleton-associated protein 5 isoform X1

UniProtKB/TrEMBL

A0A8I6ALB1, A6HNC8
XM_063283661.1 → XP_063139731.1 cytoskeleton-associated protein 5 isoform X1

UniProtKB/TrEMBL

A0A8I6ALB1, A6HNC8

Related

ENSRNOP00000094312.1, ENSRNOT00000119801.2
XM_063283667.1 → XP_063139737.1 cytoskeleton-associated protein 5 isoform X2

UniProtKB/TrEMBL

A6HNC8, F1M949
XM_063283665.1 → XP_063139735.1 cytoskeleton-associated protein 5 isoform X2

UniProtKB/TrEMBL

A6HNC8, F1M949

Related

ENSRNOP00000021837.8, ENSRNOT00000021837.10
XM_063283666.1 → XP_063139736.1 cytoskeleton-associated protein 5 isoform X2

UniProtKB/TrEMBL

A6HNC8, F1M949
XM_039106803.2 → XP_038962731.1 cytoskeleton-associated protein 5 isoform X1

UniProtKB/TrEMBL

A0A8I6ALB1, A6HNC8
XM_039106802.2 → XP_038962730.1 cytoskeleton-associated protein 5 isoform X1

UniProtKB/TrEMBL

A0A8I6ALB1, A6HNC8
XM_063283663.1 → XP_063139733.1 cytoskeleton-associated protein 5 isoform X1

UniProtKB/TrEMBL

A0A8I6ALB1, A6HNC8
XM_063283668.1 → XP_063139738.1 cytoskeleton-associated protein 5 isoform X2

UniProtKB/TrEMBL

A6HNC8, F1M949