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    Elavl3 ELAV like RNA binding protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 282824, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Elavl3provided by RGD
    Official Full Name
    ELAV like RNA binding protein 3provided by RGD
    Primary source
    RGD:628892
    See related
    EnsemblRapid:ENSRNOG00000013752 AllianceGenome:RGD:628892
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Huc
    Summary
    Predicted to enable mRNA 3'-UTR AU-rich region binding activity. Predicted to be located in nucleus. Predicted to be part of ribonucleoprotein complex. Orthologous to human ELAVL3 (ELAV like RNA binding protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 155.0) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Elavl3 in Genome Data Viewer
    Location:
    8q13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (28823120..28859395, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (20547108..20583369, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (23029980..23063477, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480147 Neighboring gene outer dynein arm docking complex subunit 3 Neighboring gene PRKCSH beta subunit of glucosidase II Neighboring gene zinc finger protein 653 Neighboring gene uncharacterized LOC120094091 Neighboring gene ECSIT signaling integrator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. NMR studies on functional structures of the AU-rich element-binding domains of Hu antigen C. Inoue M, et al. Nucleic Acids Res, 2000 Apr 15. PMID 10734193, Free PMC Article
    2. Two different RNA binding activities for the AU-rich element and the poly(A) sequence of the mouse neuronal protein mHuC. Abe R, et al. Nucleic Acids Res, 1996 Dec 15. PMID 9016658, Free PMC Article
    3. Neuron-specific Hu proteins sub-cellular localization in primary sensory neurons. Fornaro M, et al. Ann Anat, 2007. PMID 17534028
    4. RNA-binding analyses of HuC and HuD with the VEGF and c-myc 3'-untranslated regions using a novel ELISA-based assay. King PH. Nucleic Acids Res, 2000 Apr 1. PMID 10710437, Free PMC Article
    5. HuB/C/D, nPTB, REST4, and miR-124 regulators of neuronal cell identity are also utilized in the lens. Bitel CL, et al. Mol Vis, 2010 Nov 4. PMID 21139978, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Part of a family of RNa-binding proteins found in sensory neurons.
      Title: Neuron-specific Hu proteins sub-cellular localization in primary sensory neurons.
    2. The predominant expression of REST4, HuB/C/D and nPTB in post-mitotic fiber cells, together with miR-124 expression in vertebrate lenses, was shown.
      Title: HuB/C/D, nPTB, REST4, and miR-124 regulators of neuronal cell identity are also utilized in the lens.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mRNA 3'-UTR AU-rich region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ELAV-like protein 3
    Names
    ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)
    ELAV like neuron-specific RNA binding protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172324.3 → NP_758827.1  ELAV-like protein 3

      See identical proteins and their annotated locations for NP_758827.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6AIP7, Q76IJ9
      Related
      ENSRNOP00000018416.6, ENSRNOT00000018416.7
      Conserved Domains (1) summary
      TIGR01661
      Location:36 → 366
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      28823120..28859395 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242616.5 → XP_006242678.3  ELAV-like protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AIP7
      Conserved Domains (1) summary
      TIGR01661
      Location:36 → 359
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    2. XM_017595490.3 → XP_017450979.2  ELAV-like protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AIP7
      Conserved Domains (1) summary
      TIGR01661
      Location:35 → 365
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    3. XM_063264993.1 → XP_063121063.1  ELAV-like protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AIP7
    Nucleotide Protein Strain
    Heading Accession and Version

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