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    Arrdc1 arrestin domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366001, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Arrdc1provided by RGD
    Official Full Name
    arrestin domain containing 1provided by RGD
    Primary source
    RGD:1309961
    See related
    EnsemblRapid:ENSRNOG00000007622 AllianceGenome:RGD:1309961
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including arrestin family protein binding activity; ubiquitin protein ligase binding activity; and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including extracellular vesicle biogenesis; negative regulation of Notch signaling pathway; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasmic vesicle; extracellular vesicle; and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human ARRDC1 (arrestin domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 198.9), Kidney (RPKM 99.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arrdc1 in Genome Data Viewer
    Location:
    3p13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (28133190..28140378, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (7735002..7742195, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (2129876..2137161, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene calcium voltage-gated channel subunit alpha1 B Neighboring gene euchromatic histone lysine methyltransferase 1 Neighboring gene uncharacterized LOC134486057 Neighboring gene zinc finger, MYND-type containing 19 Neighboring gene diphthamide biosynthesis 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein. Nabhan JF, et al. Proc Natl Acad Sci U S A, 2012 Mar 13. PMID 22315426, Free PMC Article
    2. Regulation of the divalent metal ion transporter via membrane budding. Mackenzie K, et al. Cell Discov, 2016. PMID 27462458, Free PMC Article
    3. Α-arrestin 1 (ARRDC1) and β-arrestins cooperate to mediate Notch degradation in mammals. Puca L, et al. J Cell Sci, 2013 Oct 1. PMID 23886940
    4. Mammalian α arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with β arrestins. Shea FF, et al. PLoS One, 2012. PMID 23236378, Free PMC Article
    5. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables arrestin family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in extracellular transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in extracellular transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in extracellular vesicle biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in extracellular vesicle biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of Notch signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    arrestin domain-containing protein 1
    Names
    alpha-arrestin 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100770.1 → NP_001094240.1  arrestin domain-containing protein 1

      See identical proteins and their annotated locations for NP_001094240.1

      Status: PROVISIONAL

      Source sequence(s)
      BC158871
      UniProtKB/Swiss-Prot
      B0BNL6, Q68FT0
      Related
      ENSRNOP00000010169.4, ENSRNOT00000010169.7
      Conserved Domains (3) summary
      PHA03247
      Location:285 → 423
      PHA03247; large tegument protein UL36; Provisional
      pfam02752
      Location:162 → 284
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:7 → 139
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      28133190..28140378 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105577.2 → XP_038961505.1  arrestin domain-containing protein 1 isoform X4

      Conserved Domains (3) summary
      PHA03247
      Location:274 → 412
      PHA03247; large tegument protein UL36; Provisional
      pfam02752
      Location:125 → 273
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:14 → 102
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    2. XM_039105576.2 → XP_038961504.1  arrestin domain-containing protein 1 isoform X2

      Conserved Domains (3) summary
      PHA03247
      Location:310 → 448
      PHA03247; large tegument protein UL36; Provisional
      pfam02752
      Location:162 → 309
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:7 → 139
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    3. XM_039105575.2 → XP_038961503.1  arrestin domain-containing protein 1 isoform X1

      Conserved Domains (3) summary
      PHA03247
      Location:311 → 449
      PHA03247; large tegument protein UL36; Provisional
      pfam02752
      Location:162 → 310
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:7 → 139
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    4. XM_006233631.5 → XP_006233693.1  arrestin domain-containing protein 1 isoform X5

      See identical proteins and their annotated locations for XP_006233693.1

      UniProtKB/TrEMBL
      A6JSZ3
      Related
      ENSRNOP00000105854.1, ENSRNOT00000160561.1
      Conserved Domains (2) summary
      pfam02752
      Location:125 → 247
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:14 → 102
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    5. XM_006233630.5 → XP_006233692.1  arrestin domain-containing protein 1 isoform X3

      Conserved Domains (3) summary
      PHA03247
      Location:284 → 422
      PHA03247; large tegument protein UL36; Provisional
      pfam02752
      Location:162 → 283
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:7 → 139
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B0BNL6.1 GenPept UniProtKB/Swiss-Prot:B0BNL6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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