U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Fbxo27 F-box protein 27 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499114, updated on 27-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Fbxo27provided by RGD
    Official Full Name
    F-box protein 27provided by RGD
    Primary source
    RGD:1563982
    See related
    EnsemblRapid:ENSRNOG00000050453 AllianceGenome:RGD:1563982
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563982
    Summary
    Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in ERAD pathway; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and glycoprotein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human FBXO27 (F-box protein 27). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 28.4), Heart (RPKM 23.6) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Fbxo27 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (93092900..93115312)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (83965426..83987781)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (86872808..86878709)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene MARCKS-related protein-like Neighboring gene uncharacterized LOC108349512 Neighboring gene uncharacterized LOC134485106 Neighboring gene ribosomal protein SA, pseudogene 8 Neighboring gene acid phosphatase 7, tartrate resistant Neighboring gene F-box protein 17 Neighboring gene mitochondrial ribosomal protein S12

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. Glenn KA, et al. J Biol Chem, 2008 May 9. PMID 18203720, Free PMC Article
    2. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC108905

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycoprotein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    F-box only protein 27
    Names
    rCG54033-like

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110491.2 → NP_001103961.2  F-box only protein 27

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6J9K0, Q5BK51
      Conserved Domains (2) summary
      smart00256
      Location:37 → 64
      FBOX; A Receptor for Ubiquitination Targets
      pfam04300
      Location:102 → 275
      FBA; F-box associated region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      93092900..93115312
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039087233.2 → XP_038943161.1  F-box only protein 27 isoform X1

      UniProtKB/TrEMBL
      Q5BK51
      Related
      ENSRNOP00000100844.1, ENSRNOT00000124488.1
      Conserved Domains (2) summary
      smart00256
      Location:95 → 122
      FBOX; A Receptor for Ubiquitination Targets
      pfam04300
      Location:160 → 333
      FBA; F-box associated region

    2. XM_063270885.1 → XP_063126955.1  F-box only protein 27 isoform X5

    3. XM_063270883.1 → XP_063126953.1  F-box only protein 27 isoform X4

    4. XM_039087244.2 → XP_038943172.1  F-box only protein 27 isoform X2

      UniProtKB/TrEMBL
      M0RA85, Q5BK51
      Related
      ENSRNOP00000102758.1, ENSRNOT00000145721.1
      Conserved Domains (2) summary
      smart00256
      Location:73 → 100
      FBOX; A Receptor for Ubiquitination Targets
      pfam04300
      Location:138 → 311
      FBA; F-box associated region

    5. XM_063270892.1 → XP_063126962.1  F-box only protein 27 isoform X7

    6. XM_039087255.2 → XP_038943183.1  F-box only protein 27 isoform X2

      UniProtKB/TrEMBL
      M0RA85, Q5BK51
      Conserved Domains (2) summary
      smart00256
      Location:73 → 100
      FBOX; A Receptor for Ubiquitination Targets
      pfam04300
      Location:138 → 311
      FBA; F-box associated region

    7. XM_063270886.1 → XP_063126956.1  F-box only protein 27 isoform X6

      UniProtKB/TrEMBL
      A6J9K0, Q5BK51

    8. XM_039087261.2 → XP_038943189.1  F-box only protein 27 isoform X6

      UniProtKB/TrEMBL
      A6J9K0, Q5BK51
      Conserved Domains (2) summary
      smart00256
      Location:37 → 64
      FBOX; A Receptor for Ubiquitination Targets
      pfam04300
      Location:102 → 275
      FBA; F-box associated region

    9. XM_039087278.2 → XP_038943206.1  F-box only protein 27 isoform X6

      UniProtKB/TrEMBL
      A6J9K0, Q5BK51
      Conserved Domains (2) summary
      smart00256
      Location:37 → 64
      FBOX; A Receptor for Ubiquitination Targets
      pfam04300
      Location:102 → 275
      FBA; F-box associated region

    10. XM_039087284.2 → XP_038943212.1  F-box only protein 27 isoform X6

      UniProtKB/TrEMBL
      A6J9K0, Q5BK51
      Conserved Domains (2) summary
      smart00256
      Location:37 → 64
      FBOX; A Receptor for Ubiquitination Targets
      pfam04300
      Location:102 → 275
      FBA; F-box associated region

    11. XM_039087268.2 → XP_038943196.1  F-box only protein 27 isoform X6

      UniProtKB/TrEMBL
      A6J9K0, Q5BK51
      Conserved Domains (2) summary
      smart00256
      Location:37 → 64
      FBOX; A Receptor for Ubiquitination Targets
      pfam04300
      Location:102 → 275
      FBA; F-box associated region

    12. XM_063270889.1 → XP_063126959.1  F-box only protein 27 isoform X6

      UniProtKB/TrEMBL
      A6J9K0, Q5BK51

    13. XM_039087259.2 → XP_038943187.1  F-box only protein 27 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AGA4, Q5BK51
      Related
      ENSRNOP00000066427.4, ENSRNOT00000071239.4
      Conserved Domains (2) summary
      smart00256
      Location:62 → 89
      FBOX; A Receptor for Ubiquitination Targets
      pfam04300
      Location:127 → 300
      FBA; F-box associated region
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.